Development and content validation of measures assessing adherence barriers and behaviors for use in clinical care

Fredericksen, Rob J.; Yang, Frances M.; Gibbons, Laura E.; Edwards, Todd C.; Brown, Sharon; Fitzsimmons, Emma; Alperovitz-Bichell, Kari; Godfrey, Marjorie M.; Wang, A.; Church, Anna E.; Gutiérrez, Cristina; Páez, Edgar; Dant, Lydia; Loo, Stephanie; Walcott, Melonie; Mugavero, Michael J.; Mayer, Kenneth H.; Mathews, William C; Patrick, Donald L.; Crane, Paul K.; Crane, Heidi M.

doi:10.1016/j.sapharm.2018.10.001

Cited by 6 publications

(9 citation statements)

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“…The characteristics of the medication adherence PROM are presented in Multimedia Appendix 2 [ 38 - 51 ]. The most extensively studied PROMs were the 8-item MMAS (MMAS-8)and 4-item MMAS(MMAS-4), which were studied in 27 and 18 studies, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…The most extensively studied PROMs were the 8-item MMAS (MMAS-8)and 4-item MMAS(MMAS-4), which were studied in 27 and 18 studies, respectively. Among the 121 PROMs, 15 PROMs have been administered electronically—Adult AIDS Clinical Trials Group (AACTG) adherence items [ 52 ], Fredericksen et al [ 38 ], Item Response Theory-30 [ 53 ], LeastAbsolute Shrinkage and Selection Operator-10 [ 53 ], Medication Adherence Reasons Scale (MAR-Scale) [ 54 ], MAR-Scale (revised) [ 55 ], MARS [ 56 ], Medication Intake Survey-Asthma [ 57 ], MMAS-4 [ 54 ], MMAS-8 [ 58 ], Multiple Sclerosis Treatment Adherence Questionnaire [ 59 ], Probabilistic Medication Adherence Scale [ 56 ], Self-Rating Scale Item [ 52 ], visual analog scale [ 52 ], and WedAd-Q Questionnaire [ 60 ].…”

Section: Resultsmentioning

confidence: 99%

“…Outcomes on the assessment of methodological quality and study quality of PROMs are summarized in Multimedia Appendix 3 [ 13 , 17 , 38 - 54 , 56 , 57 , 59 , 61 - 248 ]. In terms of validity, “hypotheses testing for construct validity,”“structural validity,” and “content validity” were assessed in 181, 92, and 92 studies, respectively.…”

Section: Resultsmentioning

confidence: 99%

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Measurement Properties of Existing Patient-Reported Outcome Measures on Medication Adherence: Systematic Review

Kwan¹,

Weng²,

Loh³

et al. 2020

J Med Internet Res

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Background Medication adherence is essential for improving the health outcomes of patients. Various patient-reported outcome measures (PROMs) have been developed to measure medication adherence in patients. However, no study has summarized the psychometric properties of these PROMs to guide selection for use in clinical practice or research. Objective This study aims to evaluate the quality of the PROMs used to measure medication adherence. Methods This study was guided by the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. Relevant articles were retrieved from the EMBASE, PubMed, Cochrane Library, Web of Science, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) databases. The PROMs were then evaluated based on the COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) guidelines. Results A total of 121 unique medication adherence PROMs from 214 studies were identified. Hypotheses testing for construct validity and internal consistency were the most frequently assessed measurement properties. PROMs with at least a moderate level of evidence for ≥5 measurement properties include the Adherence Starts with Knowledge 20, Compliance Questionnaire-Rheumatology, General Medication Adherence Scale, Hill-Bone Scale, Immunosuppressant Therapy Barrier Scale, Medication Adherence Reasons Scale (MAR-Scale) revised, 5-item Medication Adherence Rating Scale (MARS-5), 9-item MARS (MARS-9), 4-item Morisky Medication Adherence Scale (MMAS-4), 8-item MMAS (MMAS-8), Self-efficacy for Appropriate Medication Adherence Scale, Satisfaction with Iron Chelation Therapy, Test of Adherence to Inhalers, and questionnaire by Voils. The MAR-Scale revised, MMAS-4, and MMAS-8 have been administered electronically. Conclusions This study identified 121 PROMs for medication adherence and provided synthesized evidence for the measurement properties of these PROMs. The findings from this study may assist clinicians and researchers in selecting suitable PROMs to assess medication adherence.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Measurement Properties of Existing Patient-Reported Outcome Measures on Medication Adherence: Systematic Review

Kwan¹,

Weng²,

Loh³

et al. 2020

J Med Internet Res

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“…Patient-Reported Measures Assessing Adherence Behaviors and Barriers in Patients Living with HIV [ 229 ]* (7 items)…”

Section: Resultsmentioning

confidence: 99%

Development of an Item Bank to Measure Medication Adherence: Systematic Review

Kwan

Loh

et al. 2020

J Med Internet Res

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Background Medication adherence is important in managing the progression of chronic diseases. A promising approach to reduce cognitive burden when measuring medication adherence lies in the use of computer‐adaptive tests (CATs) or in the development of shorter patient-reported outcome measures (PROMs). However, the lack of an item bank currently hampers this progress. Objective We aim to develop an item bank to measure general medication adherence. Methods Using the preferred reporting items for systematic review and meta-analysis (PRISMA), articles published before October 2019 were retrieved from PubMed, Embase, CINAHL, the Cochrane Library, and Web of Science. Items from existing PROMs were classified and selected (“binned” and “winnowed”) according to standards published by the Patient-Reported Outcomes Measurement Information System (PROMIS) Cooperative Group. Results A total of 126 unique PROMs were identified from 213 studies in 48 countries. Items from the literature review (47 PROMs with 579 items for which permission has been obtained) underwent binning and winnowing. This resulted in 421 candidate items (77 extent of adherence and 344 reasons for adherence). Conclusions We developed an item bank for measuring general medication adherence using items from validated PROMs. This will allow researchers to create new PROMs from selected items and provide the foundation to develop CATs.

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“…The characteristics of the medication adherence PROM are presented in Multimedia Appendix 2 [38][39][40][41][42][43][44][45][46][47][48][49][50][51]. The most extensively studied PROMs were the 8-item MMAS (MMAS-8)and 4-item MMAS(MMAS-4), which were studied in 27 and 18 studies, respectively.…”

Section: Prom Characteristicsmentioning

confidence: 99%

Measurement Properties of Existing Patient-Reported Outcome Measures on Medication Adherence: Systematic Review (Preprint)

Kwan¹,

Weng²,

Loh³

et al. 2020

Preprint

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BACKGROUND Medication adherence is essential for improving the health outcomes of patients. Various patient-reported outcome measures (PROMs) have been developed to measure medication adherence in patients. However, no study has summarized the psychometric properties of these PROMs to guide selection for use in clinical practice or research. OBJECTIVE This study aims to evaluate the quality of the PROMs used to measure medication adherence. METHODS This study was guided by the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. Relevant articles were retrieved from the EMBASE, PubMed, Cochrane Library, Web of Science, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) databases. The PROMs were then evaluated based on the COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) guidelines. RESULTS A total of 121 unique medication adherence PROMs from 214 studies were identified. Hypotheses testing for construct validity and internal consistency were the most frequently assessed measurement properties. PROMs with at least a moderate level of evidence for ≥5 measurement properties include the Adherence Starts with Knowledge 20, Compliance Questionnaire-Rheumatology, General Medication Adherence Scale, Hill-Bone Scale, Immunosuppressant Therapy Barrier Scale, Medication Adherence Reasons Scale (MAR-Scale) revised, 5-item Medication Adherence Rating Scale (MARS-5), 9-item MARS (MARS-9), 4-item Morisky Medication Adherence Scale (MMAS-4), 8-item MMAS (MMAS-8), Self-efficacy for Appropriate Medication Adherence Scale, Satisfaction with Iron Chelation Therapy, Test of Adherence to Inhalers, and questionnaire by Voils. The MAR-Scale revised, MMAS-4, and MMAS-8 have been administered electronically. CONCLUSIONS This study identified 121 PROMs for medication adherence and provided synthesized evidence for the measurement properties of these PROMs. The findings from this study may assist clinicians and researchers in selecting suitable PROMs to assess medication adherence.

show abstract

Development and content validation of measures assessing adherence barriers and behaviors for use in clinical care

Cited by 6 publications

References 50 publications

Measurement Properties of Existing Patient-Reported Outcome Measures on Medication Adherence: Systematic Review

Measurement Properties of Existing Patient-Reported Outcome Measures on Medication Adherence: Systematic Review

Development of an Item Bank to Measure Medication Adherence: Systematic Review

Measurement Properties of Existing Patient-Reported Outcome Measures on Medication Adherence: Systematic Review (Preprint)

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