Development and Deployment of a Novel Diagnostic Tool Based on Conventional Ultrasound for Fibrosis Assessment in Chronic Kidney Disease

Chen, Ziman; Chen, Jiaxin; Ying, Tin Cheung; Chen, Hui; Wu, Chaoqun; Chen, Xuehua; Huang, Yongquan; Su, Zhongzhen

doi:10.1016/j.acra.2023.02.018

Academic Radiology

2023

DOI: 10.1016/j.acra.2023.02.018

|View full text |Cite

Development and Deployment of a Novel Diagnostic Tool Based on Conventional Ultrasound for Fibrosis Assessment in Chronic Kidney Disease

Ziman Chen¹,

Jiaxin Chen²,

Tin Cheung Ying³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thirdly, although the authors proposed a radiomics model, the present study did not explore its transformation into a practical diagnostic tool. Development of an online web-based calculator to assist clinicians in applying the developed model to their actual clinical practice should be considered ( 5 ). Lastly, despite using the random forest algorithm for model construction, the authors did not explain its benefits.…”

mentioning

confidence: 99%

Ultrasound-based multiregional radiomics analysis to differentiate breast masses

Chen,

Ying

2023

Quant Imaging Med Surg

View full text Add to dashboard Cite

mentioning

confidence: 99%

Ultrasound-based multiregional radiomics analysis to differentiate breast masses

Chen,

Ying

2023

Quant Imaging Med Surg

View full text Add to dashboard Cite

Ultrasonic renal length as an indicator of renal fibrosis severity in non-diabetic patients with chronic kidney disease

Chen,

Jiang,

Gunda

et al. 2024

Clin Exp Nephrol

View full text Add to dashboard Cite

Background Debate continues regarding the potential of the ultrasonic renal length to serve as an indicator for evaluating the advancement of renal fibrosis in chronic kidney disease (CKD). This study investigates the independent association between renal length and renal fibrosis in non-diabetic CKD patients and assesses its diagnostic performance. Methods From April 2019 to December 2021, 144 non-diabetic patients diagnosed with CKD who underwent a renal ultrasound examination and kidney biopsy were prospectively enrolled. Patients were categorized into the mild fibrosis group (n = 70) and the moderate-severe group (n = 74) based on the extent of fibrotic involvement. Ultrasonic renal length was measured from pole-to-pole in the coronal plane. A receiver operating characteristic (ROC) curve, multivariable logistic regression analysis, and a generalized additive model were performed. Results A negative linear correlation was found between renal length and moderate-severe renal fibrosis risk. Each centimeter increase in renal length decreased the odds of moderate-severe fibrosis by 38% (OR: 0.62; 95% CI 0.41–0.93; P = 0.020). After adjusting for confounders, the relationship persisted (OR: 0.58; 95% CI 0.33–1.00; P = 0.048). However, renal length presented limited discrimination ability in distinguishing degrees of renal fibrosis while controlling the key confounding factors, yielding an area under the ROC curve of only 0.58 (95% CI 0.45–0.70). Conclusion While an inverse relationship exists between renal length and risk of having moderate-severe renal fibrosis in non-diabetic CKD patients, renal length alone is insufficient for diagnosing fibrosis severity, underscoring the need for additional diagnostic parameters in CKD assessment.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Development and Deployment of a Novel Diagnostic Tool Based on Conventional Ultrasound for Fibrosis Assessment in Chronic Kidney Disease

Cited by 2 publications

References 40 publications

Ultrasound-based multiregional radiomics analysis to differentiate breast masses

Ultrasound-based multiregional radiomics analysis to differentiate breast masses

Ultrasonic renal length as an indicator of renal fibrosis severity in non-diabetic patients with chronic kidney disease

Contact Info

Product

Resources

About