Development and Developmental Disorders of the Brain Stem

ten Donkelaar, Hans J.; Fritzsch, Bernd; Cruysberg, Johannes R. M.; Pennings, Ronald J. E.; Smits, Jeroen J.; Lammens, Martin

doi:10.1007/978-3-031-26098-8_7

Clinical Neuroembryology 2023

DOI: 10.1007/978-3-031-26098-8_7

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Development and Developmental Disorders of the Brain Stem

Hans J. ten Donkelaar,

Bernd Fritzsch,

Johannes R. M. Cruysberg

et al.

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2024

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Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain

Pyott,

Pavlinkova,

Yamoah

et al. 2024

Annual Review of Neuroscience

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Auditory processing in mammals begins in the peripheral inner ear and extends to the auditory cortex. Sound is transduced from mechanical stimuli into electrochemical signals of hair cells, which relay auditory information via the primary auditory neurons to cochlear nuclei. Information is subsequently processed in the superior olivary complex, lateral lemniscus, and inferior colliculus and projects to the auditory cortex via the medial geniculate body in the thalamus. Recent advances have provided valuable insights into the development and functioning of auditory structures, complementing our understanding of the physiological mechanisms underlying auditory processing. This comprehensive review explores the genetic mechanisms required for auditory system development from the peripheral cochlea to the auditory cortex. We highlight transcription factors and other genes with key recurring and interacting roles in guiding auditory system development and organization. Understanding these gene regulatory networks holds promise for developing novel therapeutic strategies for hearing disorders, benefiting millions globally. Expected final online publication date for the Annual Review of Neuroscience, Volume 47 is July 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain

Pyott,

Pavlinkova,

Yamoah

et al. 2024

Annual Review of Neuroscience

View full text Add to dashboard Cite

show abstract

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Development and Developmental Disorders of the Brain Stem

Cited by 1 publication

References 503 publications

Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain

Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain

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