Development and Evaluation of a Hydrogel containing Momordica cochinchinensis Spreng Extract for Topical Applications

Abstract

The purpose of this research was to develop a hydrogel containing the extract of Gac fruit (Momordica cochinchinensis Spreng) with appropriate physicochemical properties and good dermatological efficacy. The Gac aril fruit was extracted by maceration in dichloromethane, and its antioxidant activity was determined through a DPPH assay. The very low water-solubility of the Gac extract is responsible for its incompatibility with the hydrogel. To overcome this drawback, Labrafac TM PG and Tween 60 were used to develop the hydrogel due to their potent potential for solubilizing the Gac extract. The prepared hydrogels displayed good physical properties, a homogenous orange gel, appropriate pH, and viscosity. After storage in an accelerated condition for six months, the hydrogels of the Gac extract had physical stability and high remaining amounts of beta-carotene and lycopene within the range of 90.25 -94.61%. The skin efficacy of hydrogel containing the Gac fruit extract was found using 14 healthy female volunteers over a 30-day period of daily application. Topical application of the hydrogel containing the Gac fruit extract, which contains antioxidants, significantly moisturizes the skin and enhanced its elasticity (p ≤ 0.05; ANOVA). This makes it suitable for use as a skin care product.

O Pentáculo Do Bem Estar Como Instrumento De Avaliação Do Modo De Vida Na Atenção Primária a Saúde

“…Os carotenoides são os responsáveis por essa característica, que além de estética, detém atividades biológicas baseadas em licopeno e b-caroteno. Ademais, a partir da extração química de sua semente, é possível obter mais compostos, incluindo principalmente os ácidos graxos e saponinas (PLYDUANG, et al 2022). Os carotenoides atuam principalmente no sistema de defesa como antioxidantes, nas funções do sistema cardiovascular, e juntamente com as saponinas, depuradores sanguíneos (KAISER, et al 2010).…”

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

“…Examples of used carotenoids are as follows: lycopene loaded in a lipid nanocarrier in TDD systems; β-carotene in TDS as self-nanoemulsion or as lipid base nanocarriers, or as hydrogel with plant extracts; lutein with a high antioxidant effect is delivered in TDS using nanostructured lipid carriers, solid lipid nanoparticles, a nanosphere, a liposome, nanoemulsions, and polymeric nanoparticles for eye diseases, for anti-inflammatory effects, obesity, etc. ; and crocin in a nanocellulose membrane of microbial cellulose-based TP [258][259][260][261][262][263][264]. -Polyterpenoids are polymeric isoprenoid hydrocarbons, which consist of more than eight isoprene units.…”