Development and evaluation of biodegradable polymeric lomustine nanofibres for the efficient tumor targeting: In vitro characterization, ex vivo permeation and degradation study

Khan, Iram; Pandit, Jayamanti; Ahmed, Shakeeb; Zameer, Saima; Nikita,; Ahmad, Saeem; Bano, Shahnaj; Ansari, Mohd Danish; Solanki, Pavitra; Jahan, Rao Nargis; Waheed, Ayesha; Aqil, Mohd.; Sultana, Yasmin

doi:10.1016/j.jddst.2022.103685

Cited by 9 publications

(3 citation statements)

References 25 publications

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“…As indicated in Table , the specificity of the projected concentration acquired after the three periods of thaw–freeze was observed to be at 37 °C for a short duration while it was −20 °C for a longer duration of 14 days in the ranges of 91–102.1% SD for posaconazole and 88.2–100.5% SD for hemp seed oil. The findings suggest that neither the drug nor the oil deteriorated over the various storage settings. − …”

Section: Resultsmentioning

confidence: 91%

Simultaneous Determination of Posaconazole and Hemp Seed Oil in Nanomicelles through RP-HPLC via a Quality-by-Design Approach

et al. 2023

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The present study involves the development of a reverse-phase HPLC method employing the quality-by-design methodology for the estimation of posaconazole and hemp seed oil simultaneously in nanomicelles formulation. The successful separation of posaconazole and hemp seed oil was achieved together, and this is the first study to develop and quantify posaconazole and hemp seed oil nanomicelles with linoleic acid as the internal standard and developed a dual drug analytical method employing a quality-by-design approach. The study was performed on a Shimadzu Prominence-I LC-2030C 3D Plus HPLC system with a PDA detector and the Shim-pack Solar C8 column (250 mm × 4.6 mm × 5 μm) for analysis with a mobile phase ratio of methanol:water (80:20% v/v) maintaining the flow rate of 1.0 mL/min. The final wavelength was selected as 240 nm and the elution of hemp seed oil and posaconazole was obtained at 2.7 and 4.6 min, respectively, with a maximum run time of 8.0 min. Box Behnken design was employed to optimize the method, keeping the retention time, peak area, and theoretical plates as dependent variables, while the mobile phase composition, flow rate, and wavelengths were chosen as independent variables. Parameters such as specificity, accuracy, robustness, linearity, sensitivity, precision, ruggedness, and forced degradation study were performed to validate the method. The calibration curves of posaconazole and hemp seed oil were determined to be linear throughout the range for concentration. The suggested approach can be effectively utilized for estimating the content of drugs from their nanoformulation and proved suitable for both in vivo and in vitro research.

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Section: Resultsmentioning

confidence: 91%

Simultaneous Determination of Posaconazole and Hemp Seed Oil in Nanomicelles through RP-HPLC via a Quality-by-Design Approach

et al. 2023

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“…Biphasic release offers the combined advantages of rapid and sustained release, holding promising applications in various fields such as cancer treatment [ 78 , 79 , 80 ], bone tissue regeneration [ 81 , 82 , 83 , 84 ], wound healing [ 85 , 86 , 87 , 88 ], rotator cuff tendon tears [ 89 ], and eye diseases [ 90 ].…”

Section: Drug Release Modes Of Drug-loaded Nanofibersmentioning

confidence: 99%

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

Yang,

Zhang,

Liang

et al. 2024

Polymers

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In the 21st century, chemotherapy stands as a primary treatment method for prevalent diseases, yet drug resistance remains a pressing challenge. Utilizing electrospinning to support chemotherapy drugs offers sustained and controlled release methods in contrast to oral and implantable drug delivery modes, which enable localized treatment of distinct tumor types. Moreover, the core–sheath structure in electrospinning bears advantages in dual-drug loading: the core and sheath layers can carry different drugs, facilitating collaborative treatment to counter chemotherapy drug resistance. This approach minimizes patient discomfort associated with multiple-drug administration. Electrospun fibers not only transport drugs but can also integrate metal particles and targeted compounds, enabling combinations of chemotherapy with magnetic and heat therapies for comprehensive cancer treatment. This review delves into electrospinning preparation techniques and drug delivery methods tailored to various cancers, foreseeing their promising roles in cancer treatment.

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“…Degradable polymers, the most preferable candidates as scaffolds for tissue engineering, can be further classified in terms of their origin as natural or synthetic. In anticancer treatments, degradable polymers, e.g., poly (vinyl alcohol) (PVA), poly (β-hydroxybutyrate-β-hydroxyvalerate) (PHBV), poly (lactic-co-glycolic acid) (PLGA), polycaprolactone (PCL), and polylactic acid (PLA) nanofibers, serve as scaffolds and site-specific drug delivery systems [ 47 , 48 , 49 , 50 ].…”

Section: Fibrous Scaffolds For Anticancer Treatmentsmentioning

confidence: 99%

A Comprehensive Review of Electrospun Fibers, 3D-Printed Scaffolds, and Hydrogels for Cancer Therapies

Zaszczyńska

Niemczyk-Soczynska

2022

Polymers

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Anticancer therapies and regenerative medicine are being developed to destroy tumor cells, as well as remodel, replace, and support injured organs and tissues. Nowadays, a suitable three-dimensional structure of the scaffold and the type of cells used are crucial for creating bio-inspired organs and tissues. The materials used in medicine are made of non-degradable and degradable biomaterials and can serve as drug carriers. Developing flexible and properly targeted drug carrier systems is crucial for tissue engineering, regenerative medicine, and novel cancer treatment strategies. This review is focused on presenting innovative biomaterials, i.e., electrospun nanofibers, 3D-printed scaffolds, and hydrogels as a novel approach for anticancer treatments which are still under development and awaiting thorough optimization.

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Development and evaluation of biodegradable polymeric lomustine nanofibres for the efficient tumor targeting: In vitro characterization, ex vivo permeation and degradation study

Cited by 9 publications

References 25 publications

Simultaneous Determination of Posaconazole and Hemp Seed Oil in Nanomicelles through RP-HPLC via a Quality-by-Design Approach

Simultaneous Determination of Posaconazole and Hemp Seed Oil in Nanomicelles through RP-HPLC via a Quality-by-Design Approach

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

A Comprehensive Review of Electrospun Fibers, 3D-Printed Scaffolds, and Hydrogels for Cancer Therapies

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