Development and Evaluation of Brain Tumor Targeted Liposome Delivery System for Paclitaxel

Abstract

Wood, who has in every way been available as a resource be it emotionally, socially, scholarly, or administratively. I cannot overstate the importance of his involvement in my graduate career. I would like to gratefully acknowledge the enthusiastic technical support of Dr. M. Waleed Gaber for the scientific discussions on optical imaging. I would also

Lyophilized Iron Oxide Nanoparticles Encapsulated in Amphotericin B: A Novel Targeted Nano Drug Delivery System for the Treatment of Systemic Fungal Infections

“…The transferrin-bound design D formulation has significantly lower IC90 values over AMB-D for clinical isolates tested ( Figure 13A). This small feasibility study results (n = 1) indicated that transferrin can also potentially be used as targeting ligand, particularly for targeting CNS, where transferrin receptors are overexpressed during inflammation or tumor growth [39]. Similar results were observed with a dual drug loading formulation, with AMB and curcumin ( Figure 13B).…”

Development and Evaluation of Paclitaxel-Loaded Liposomal Formulations for Targeted Drug Delivery to Breast Cancer

“…Tf conjugated liposomes was proposed as strategy to improve the uptake of drug in brain. Paclitaxel was delivered to mice bearing C6 glioma tumors in the brain using Tf-PEG liposomes [159]. The uptake of Tf-PEG liposomes in the brain was supported by non invasive near infrared fluorescence (NIRF) imaging.…”

“…Transferrin was non-covalently conjugated to biotin on the distal end of the PEG spacers of the biotinylated SUVs using the procedure established in our laboratory [159]. Briefly, streptavidin was dissolved in PBS to prepare a 2 nM solution.…”