Development and Evaluation of Chitosan Based Polymeric Nanoparticles of an Antiulcer Drug Lansoprazole

Nagarajan, Elangovan; Shanmugasundaram, P.; Ravichandiran, V.; Vijayalakshmi, A.; Senthilnathan, B.; Masilamani, K.

doi:10.7324/japs.2015.50404

Cited by 38 publications

(23 citation statements)

References 10 publications

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“…Entrapment efficiency was found to be dependent on the concentration of the chitosan so more entrapment efficiency was obtained with higher polymer concentration. The similar results were reported by Nagarajan et al, (2015) that entrapment efficiency of Lansoprazole loaded chitosan nanoparticles increased from 39.3±2.6% and 85.6±1.2% as the amount of chitosan increased 24 . Patil et al, (2014) formulated doxorubicin loaded spray dried chitosan nanocarriers and concluded that particles formed with maximum chitosan concentration resulted in increased entrapment efficiency 25 .…”

Section: Optimization Techniquesupporting

confidence: 79%

“…The release drug content was decreased with increase in chitosan concentration 24 .Sriramet al, (2013) studied that the results of the in-vitro dissolution studies of formulations F1 to F5 showed 94.92 % cumulative drug release at the end of 12 h while F5 formulation showed 78.67 % cumulative drug release at the end of 12 h. This is because with increase in polymer concentration the free drug concentration on the surface of microspheres will be decreased and more drug get entrapped in the microspheres and drug gets released slowly 26 .…”

Section: In-vitro Drug Release Studiesmentioning

confidence: 92%

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Chitosan Loaded Microspheres of Tropicamide as Controlled Release of Drug for Ocular Drug Delivery System

Saini¹,

Kumar²,

Choudhary³

et al. 2017

Int. Res. J. Pharm.

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Ocular drug delivery via conventional eye drop is a convenient route of administration but it has serious limitations due to rapid clearance of the formulation from the eye. This study aimed to prepare and evaluate the sustained/controlled release of tropicamide microspheres with chitosan to increase ocular residence time of drug and also improve the bioavailability. The tropicamide loaded chitosan microspheres were prepared by ionic gelation technique using different ratios of polymer i.e. chitosan and cross-linking polymer i.e. sodium TPP. Microspheres were optimized by employing (2 2 ) factorial design and evaluated for particle size, entrapment efficiency, surface morphology and drug release profile. The entrapment efficiency was found to be higher with increase in the chitosan concentration. The increasing concentration of chitosan also showed the sustained release effect on the drug release. The optimized formulation showed the smooth morphology and average particle size was found to be about 15µm.The in-vitro release profile of tropicamide loaded microspheres showed a sustained release pattern as compared to pure drug. The results revealed that microspheres would be the promising candidates for enhancing the residence time by mucoadhesion which leads to enhancement of bioavailability of the tropicamide drug.

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Section: Optimization Techniquesupporting

confidence: 79%

Section: In-vitro Drug Release Studiesmentioning

confidence: 92%

Chitosan Loaded Microspheres of Tropicamide as Controlled Release of Drug for Ocular Drug Delivery System

Saini¹,

Kumar²,

Choudhary³

et al. 2017

Int. Res. J. Pharm.

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“…21 Nanoparticles coated with the polysaccharide CS have attracted a special interest for mucoadhesive applications, mainly, because of its ability to interact with the negatively charged mucosal surface and to increase the absorption of drugs by reorganizing tight junctions (TJ) between mucosal cells. 22 Recently, the use of CS as surface coating for nanoparticle-medicated drug delivery in cancer was reported in many studies. 23,24 The objective of this study is to evaluate the potential of nanoformulation and surface coating with mucoadhesive CS to enhance bioavailability and reduce the possible systemic and local diarrheal side effect of DCN after oral administration.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-coated diacerein nanosuspensions as a platform for enhancing bioavailability and lowering side effects: preparation, characterization, and ex vivo/in vivo evaluation

Allam¹,

Hamdallah²,

Abdallah³

2017

IJN

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Nanodrug delivery systems have been widely reviewed for their use in several drug formulations to improve bioavailability, sustain effect, and decrease side effects of many candidate drugs. The objective of this study was to evaluate the potential of chitosan (CS)-coated nanosuspensions to enhance bioavailability and reduce the diarrheal side effect of diacerein (DCN) after oral administration. DCN nanosuspensions (DNS) were prepared by sonoprecipitation technique using different stabilizers at three different concentrations. The selected DNS with optimum particle size (PS), polydispersity index (PDI), and Zeta potential (ZP) was coated with three different concentrations of CS-coated DNS (CS-DNS) and screened. In vitro dissolution was performed for the selected lyophilized formulae and compared with DCN powder in addition to the assessment of drug crystallinity via scanning electron microscopy, X-ray powder diffraction, and differential scanning calorimetry. Ex vivo drug permeability using noneverted rat intestine, intraluminal content, and mucoadhesion evaluation was studied for nominated formulae in comparison to DCN suspension. Moreover, in vivo study, pharmacokinetic parameters, and evaluation of diarrheal potential were conducted after oral administration of selected formulae. Polyvinyl pyrrolidone (PVP)-stabilized DNS showed a significant increase ( P ≤0.05) in PS and PDI as the stabilizer concentration increased. PVP-stabilized DNS with the lowest CS concentration was protected from aggregation by lyophilization with mannitol. A remarked enhancement in dissolution parameters was observed in the nanocrystals’ formulae. Morphological examination and X-ray diffraction confirmed drug crystallinity. The intermediate permeation parameters of CS-DNS-F10, lowest rhein-to-DCN ratio in intraluminal content along with the highest percentage of mucoadhesive, could serve as a sustaining profile of coated formula. CS-DNS-F10 showed a significantly higher C max of 0.74±0.15 µg/mL at a delayed T max of 3.60±0.55 hours with a relative bioavailability of 172.1% compared to DCN suspension. CS-coated nanosuspensions could serve as promising revenue to enhance bioavailability and reduce the diarrheal side effect of DCN after oral administration.

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“…Mucoadhesivity is a desired property for the delivery of drugs to mucosal tissues. Chitosan also has a very low toxicity [4]. …”

Section: Introductionmentioning

confidence: 99%

Functional Performance of Chitosan/Carbopol 974P NF Matrices in Captopril Tablets

Aguilar-López

Villafuerte-Robles

2016

Journal of Pharmaceutics

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Chitosan and Carbopol have been used to form a complex through an electrostatic interaction between the protonated amine (NH3+) group of chitosan and the carboxylate (COO−) group of Carbopol. In situ polyelectrolyte complexes formations based on the physical mixture of chitosan and sodium alginate were found and could be used as an oral controlled release matrix. The aim of this work is the assessment of a possible interaction between the particles of chitosan and Carbopol 974P NF that could modify their technological performance in captopril tablets. The drug and excipients were evaluated as mixtures of powders and tablets. The mixtures with captopril contained Carbopol 974P NF, chitosan, or a 1 : 1 mixture thereof with polymer proportions of 10%, 20%, and 30%. The evaluated parameters were the powder flow rate, the powder compressibility index, and the compactibility and release behavior of the tablets. The observed technological behavior points out to a greater interaction between the particles of polymers with different charge than between particles of the individual polymers. This produces more coherent matrices restricting more efficiently the drug dissolution, more coherent tablets with higher compactibility, and less flowing powder mixtures. All this, however, requires additional investigation to confirm the current results.

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Development and Evaluation of Chitosan Based Polymeric Nanoparticles of an Antiulcer Drug Lansoprazole

Cited by 38 publications

References 10 publications

Chitosan Loaded Microspheres of Tropicamide as Controlled Release of Drug for Ocular Drug Delivery System

Chitosan Loaded Microspheres of Tropicamide as Controlled Release of Drug for Ocular Drug Delivery System

Chitosan-coated diacerein nanosuspensions as a platform for enhancing bioavailability and lowering side effects: preparation, characterization, and ex vivo/in vivo evaluation

Functional Performance of Chitosan/Carbopol 974P NF Matrices in Captopril Tablets

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