Development and evaluation of delivery systems for quercetin: A comparative study between coarse emulsion, nano-emulsion, high internal phase emulsion, and emulsion gel

Du, Xiaoqian; Hu, Miao; Liu, Guannan; Qi, Baokun; Zhou, Shijiao; Lu, Keyang; Xie, Fang; Zhu, Xuemei; Li, Yang

doi:10.1016/j.jfoodeng.2021.110784

Cited by 73 publications

(23 citation statements)

References 56 publications

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“…In the yield of polysaccharides, microwave power and microwave time were also highly correlated. However, the correlation coefficient between liquid-solid ratio and microwave power and microwave time was larger than that in the yield of essential oil, and the correlation coefficient between the mole number of lithium and liquid-solid ratio, microwave power, and microwave time was smaller than that in the yield of essential oil, the above rules are consistent with those described by Xiaoqian Du et al [43]. Because every single factor between the essential oil and polysaccharide yield has a significant correlation, to further filter out the most useful data in all experimental data information, the next step we will use the PCA method will be more high correlation between the single factor into unrelated minority variables, to analyze the characteristics of essential oil and polysaccharide.…”

Section: Correlation Analysissupporting

confidence: 89%

“…Xiaoqian Du et al [43]. Because every single factor between the essential oil and polysaccharide yield has a significant correlation, to further filter out the most useful data in all experimental data information, the next step we will use the PCA method will be more high correlation between the single factor into unrelated minority variables, to analyze the characteristics of essential oil and polysaccharide.…”

Section: Correlation Analysismentioning

confidence: 99%

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An Efficient Approach for Separating Essential Oil and Polysaccharides Simultaneously from Fresh Leaves of Guajava by Microwave-Mediated Hydrodistillation with Lithium Salts and Antibacterial Activity of Essential Oil

et al. 2022

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The essential oils and polysaccharides from guava leaves have important functions. In the process of microwave extraction of plant essential oils and polysaccharides, pretreatment with lithium salts solution is helpful to increase the extraction rate. The experiment was conducted using a single factor method. Results were optimized by principal component analysis and response surface optimization. The optimal conditions were: LiCl dosage 45 μmol, microwave time 40 min, liquid-solid ratio 10, homogenization time 4.2 min, liquid-material ratio 10, and microwave irradiation power 700 W. The highest yield of essential oil and polysaccharide were 10.27 ± 0.58 mL/kg dry weight (DW) and 50.31 ± 1.88 g/kg·DW, respectively. Three verification experiments showed that the extraction rate of the microwave method was higher than that of the traditional heating method. In addition, the bacteriostatic zones reached the maximum 23.7 ± 0.11 mm when the concentration was 40 μL/mL, and the above results have practical significance.

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Section: Correlation Analysissupporting

confidence: 89%

Section: Correlation Analysismentioning

confidence: 99%

An Efficient Approach for Separating Essential Oil and Polysaccharides Simultaneously from Fresh Leaves of Guajava by Microwave-Mediated Hydrodistillation with Lithium Salts and Antibacterial Activity of Essential Oil

et al. 2022

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“…For example, soft materials exhibiting a range of properties have been designed and delivered using various emulsion carrier technologies to take advantage of the different dispersed-phase properties. As previously reported [ 4 ], the dispersed phase of an emulsion system can encapsulate the same soft materials despite differences in the carrier structure, and this is achieved throughout diversified selection and a design based on the nature of the internal packaging.…”

Section: Applications On the Dispersed-phase Scalementioning

confidence: 87%

Progress in the Application of Food-Grade Emulsions

Jie

Chen

2022

Foods

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The detailed investigation of food-grade emulsions, which possess considerable structural and functional advantages, remains ongoing to enhance our understanding of these dispersion systems and to expand their application scope. This work reviews the applications of food-grade emulsions on the dispersed phase, interface structure, and macroscopic scales; further, it discusses the corresponding factors of influence, the selection and design of food dispersion systems, and the expansion of their application scope. Specifically, applications on the dispersed-phase scale mainly include delivery by soft matter carriers and auxiliary extraction/separation, while applications on the scale of the interface structure involve biphasic systems for enzymatic catalysis and systems that can influence substance digestion/absorption, washing, and disinfection. Future research on these scales should therefore focus on surface-active substances, real interface structure compositions, and the design of interface layers with antioxidant properties. By contrast, applications on the macroscopic scale mainly include the design of soft materials for structured food, in addition to various material applications and other emerging uses. In this case, future research should focus on the interactions between emulsion systems and food ingredients, the effects of food process engineering, safety, nutrition, and metabolism. Considering the ongoing research in this field, we believe that this review will be useful for researchers aiming to explore the applications of food-grade emulsions.

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“…This has been shown to result in a higher percentage of the unmetabolized cannabinoid being distributed to the body (Zgair et al 2017 ). Nanotechnology has allowed for the development of cannabinoid and other phytochemical products with higher bioavailability than non-nano-treated products (Atsmon et al 2018 ; Nakano et al 2019 ; Du et al 2022 ; Wang et al 2008 ; Lin et al 2011 ; Gunasekaran et al 2014 ; Wu et al 2008 ). Because serum protein binding of cannabinoids is extremely rapid and nano-treated cannabinoid droplets entering the bloodstream in the intestine are so small, serum protein binding of the cannabinoids prior to entering the liver may help to further avoid first-pass metabolism (Fanali et al 2011 ; Grotenhermen 2003 ).…”

Section: Discussionmentioning

confidence: 99%

The effects of subacute exposure to a water-soluble cannabinol compound in male mice

et al. 2022

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Background Cannabinol (CBN) is one of the many cannabinoids present in Cannabis sativa and has been explored as a potential treatment for sleeplessness. The purpose of this study was to determine the physiological and behavioral effects of subacute exposure to therapeutic and low pharmacological levels of a mechanically formed, stabilized water-soluble cannabinol nano-emulsion (CBNight™). Methods Sixty-two male mice were randomly assigned to one of six treatment groups given CBNight™ at dosages designed to deliver 0mg (control) to 4 mg/kg of CBN daily via oral gavage for 14 days. In-cage behavior was observed at 30 minutes and at 2, 4, 8, and 16 hours after each dose. After 14 days, the mice were sacrificed and necropsied. Organs were weighed and inspected for gross abnormalities, and blood was collected via cardiac puncture for clinical chemistry. Results No dosage-dependent adverse effects on behavior, body mass, or blood chemistry were observed, except that the highest doses of CBNight™ were associated with significantly lower eosinophil counts. Conclusions The commercially available, water-soluble CBN compound employed in this study does not appear to cause adverse effects in mice; rather, it appears to be well tolerated at pharmacological levels. The findings of eosinopenia at higher doses of CBN and lack of hepatotoxicity at any dosage employed in this study have not been reported to date.

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Development and evaluation of delivery systems for quercetin: A comparative study between coarse emulsion, nano-emulsion, high internal phase emulsion, and emulsion gel

Cited by 73 publications

References 56 publications

An Efficient Approach for Separating Essential Oil and Polysaccharides Simultaneously from Fresh Leaves of Guajava by Microwave-Mediated Hydrodistillation with Lithium Salts and Antibacterial Activity of Essential Oil

An Efficient Approach for Separating Essential Oil and Polysaccharides Simultaneously from Fresh Leaves of Guajava by Microwave-Mediated Hydrodistillation with Lithium Salts and Antibacterial Activity of Essential Oil

Progress in the Application of Food-Grade Emulsions

The effects of subacute exposure to a water-soluble cannabinol compound in male mice

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