Development and evaluation of dual controlled release microballoons containing riboflavin and citric acid:<i>in vitro</i>and<i>in vivo</i>evaluation

Singh, Amriteshwar N; Pathak, Kamla

doi:10.3109/02652048.2011.576788

Cited by 10 publications

(5 citation statements)

References 23 publications

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“…The presence of the sharp peak indicated high purity of an anhydrous crystalline molecule 45. The thermogram detected broad peaks at 115°C and 121.15°C of pure xanthan and pure TKP, respectively.…”

Section: Resultsmentioning

confidence: 94%

Gastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy

Razavi¹,

Karimian²,

Yeong³

et al. 2016

DDDT

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This study aimed to formulate floating gastroretentive tablets containing metformin hydrochloric acid (HCl), using various grades of hydrogel such as tamarind powders and xanthan to overcome short gastric residence time of the conventional dosage forms. Different concentrations of the hydrogels were tested to determine the formulation that could provide a sustained release of 12 h. Eleven formulations with different ratios of tamarind seed powder/tamarind kernel powder (TKP):xanthan were prepared. The physical parameters were observed, and in vitro drug-release studies of the prepared formulations were carried out. Optimal formulation was assessed for physicochemical properties, thermal stability, and chemical interaction followed by in vivo gamma scintigraphy study. MKP3 formulation with a TKP:xanthan ratio of 3:2 was found to have 99.87% release over 12 h. Furthermore, in vivo gamma scintigraphy study was carried out for the optimized formulation in healthy New Zealand White rabbits, and the pharmacokinetic parameters of developed formulations were obtained. 153Sm2O3 was used to trace the profile of release in the gastrointestinal tract of the rabbits, and the drug release was analyzed. The time (Tmax) at which the maximum concentration of metformin HCl in the blood (Cmax) was observed, and it was extended four times for the gastroretentive formulation in comparison with the formulation without polymers. Cmax and the half-life were found to be within an acceptable range. It is therefore concluded that MKP3 is the optimal formulation for sustained release of metformin HCl over a period of 12 h as a result of its floating properties in the gastric region.

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Section: Resultsmentioning

confidence: 94%

Gastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy

Razavi¹,

Karimian²,

Yeong³

et al. 2016

DDDT

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“…Initially the polymer chain was relaxed that facilitates the drug release, after sometime pH dependent polymers swells and forms closely packed networks which hinders further entry of dissolution medium thus results in sustained drug release characteristics. 23 …”

Section: Resultsmentioning

confidence: 99%

Pantoprazole Sodium Loaded Microballoons for the Systemic Approach: In Vitro and In Vivo Evaluation

2017

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Purpose: Various floating and pulsatile drug delivery systems suffer from variations in the gastric transit time affecting the bioavailability of drugs. The objective of the study was to develop Pantoprazole Sodium (PAN) microballoons that may prolong the gastric residence time and could enhance the drug bioavailability.Methods: Microballoons were prepared using Eudragit®L100 by adopting emulsion solvent diffusion method with non-effervescent approach, in vitro studies were performed and the in vivo evaluation was carried out employing ethanol induced ulceration method. Optimization and validation were carried out through Design Expert® software.Results: The results demonstrate an increase in percentage yield, buoyancy, encapsulation efficacy and swelling. Particles were in the size range 80-100 µm following zero order release pattern. SEM study revealed their rough surface with spherical shape, internal cavity and porous walls. DSC thermo gram confirms the encapsulation of drug in amorphous form. Significant anti ulcer activity was observed for the prepared microballoons. The calculated ulcer index and protection were 0.20±0.05 and 97.43 % respectively for LRS-O (optimized formulation).Conclusion: This kind of pH dependent drug delivery may provide an efficient dosage regimen with enhanced patient compliance.

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“…The samples withdrawn was diluted with 0.1N HCl buffer appropriately before analysis at 265 nm with a UV VIS Spectrophotometer (Shimadzu UV-1700). All the measurement was done in triplicate, and the average was plotted [21][22][23].…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Preparation and in-Vitro Estimation for Gastroretentive Floating Hollow – Microspheres of Famotidine

NEHA SINGH,

SHIVAKUMAR HN,

AVICHAL KUMAR

2024

Asian J Pharm Clin Res

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Objective: The present study’s objectives were to prepare and evaluate gastroretentive floating hollow-microspheres (HM) of the selected Famotidine (FM) to enhance its retention time within the stomach. Methods: HM was prepared by solvent emulsion diffusion technique utilizing various polymers such as ethyl cellulose, eudragit L100, eudragit S100 as polymers, and Dichloromethane and methanol as solvents. The formulated HM was estimated for their particle-size, entrapment efficiency, floating ability, scanning electron microscopy, and in vitro drug release of drug. Results: The average particle-size of the formulated HM was within the range of 262.3±3.5 to 323.1±2.1μm. The SEM confirmed the smooth surface, sphere shape, and hollow cavity within it. The formulated microspheres showed good floating behavior for up to 8 h because of their low particle size. The invitro release profile of the HM displayed a controlled-release of FM microspheres in pH1.2 for up to 8 h. Conclusion: The result depicts that the formulated HM of FM by virtue of good floating time and sustained release properties is likely to improve the retention time within the stomach and thereby the oral bioavailability.

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Development and evaluation of dual controlled release microballoons containing riboflavin and citric acid:in vitroandin vivoevaluation

Cited by 10 publications

References 23 publications

Gastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy

Gastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy

Pantoprazole Sodium Loaded Microballoons for the Systemic Approach: In Vitro and In Vivo Evaluation

Preparation and in-Vitro Estimation for Gastroretentive Floating Hollow – Microspheres of Famotidine

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