Development and Evaluation of Fast Disintegrating Tablets Containing Lornoxicam Solid Dispersions

Abstract

Lornoxicam is a non steroidal anti-inflammatory drug (NSAID) of the oxicam class. It belongs to BCS class II substance with low solubility and high permeability. The aim of current research is to formulate solid dispersion incorporated Fast disintegrating tablets of Lornoxicam to enhance the dissolution rate and aqueous solubility and to enable faster onset of action. Solid dispersions are prepared with polymers like Kolliwax GMS, Soluplus and HPMC in three different ratios 1:1:1, 1:2:1 and 1:3:1. Formulations were characterized for drug content studies, drug release studies and drug-polymer interactions using Fourier transform infrared spectroscopy (FTIR) spectrum. The solid dispersions can be evaluated by in-vitro dissolution studies. The optimized solid dispersion SD9 was further used to prepare fast disintegrating tablet by direct compression method using 3 3 Response surface method (3 variables and 3 levels of superdisintegrants) by using Design of experiment software with superdisintegrants like locust bean gum, gum karaya, Plant ago ovata. The values of pre-compression parameters evaluated were within prescribed limits that indicated good free flowing properties. The data obtained of post-compression parameters such as weight variation, hardness, friability, content uniformity, disintegration time (33 sec) and percentage drug release was maximum in LF24(99.21±1.87%) and was found to superior over conventional formulation. It can be concluded that fast disintegrating tablets using Lornoxicam solid dispersion could be used to improve better patient compliance in the effective management of pain and inflammation.

Phytochemical and Biological Investigations of <em>Ficus carica</em> L. Leaf Extract Along with Formulation Development

“…According to this method weight variation test of tablets was performed by measuring weight of 20 tablets individually and average weight was calculated. If two or more of the single tablet weights vary from the 7.5 percent percentile limit, the tablets are considered to pass the test [49].…”

“…Vernier-calipers were used to measure the tablets' thickness and diameter, and their measurements in millimeters (mm) were recorded [49].…”