Development and Evaluation of HPMC Based Matrices for Transdermal Patches of Tramadol

Chandak, Ashok; Verma, Priya Ranjan Prasad

doi:10.1080/10601330701885066

Cited by 21 publications

(18 citation statements)

References 21 publications

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“…Since no other endothermic event was observed, one can conclude that there was no interaction between the drug and polymer used. This study also indicates that the polymeric grades used are well suited for formulating matrix type patches because of their compatibility with the drugs (11,17).…”

Section: Dscmentioning

confidence: 95%

“…Of the various formulations made using different concentrations and grades of HPMC, six formulations (A-F) were selected on the basis of the drug content and release pattern. The release patterns of the selected formulations were best suited for Higuchi kinetics, with a significant linear correlation (R = 0.968-0.981, p < 0.001, Table II) indicating slow and controlled drug release, thus supporting the selected formulation suitable for transdermal films (11).…”

Section: In Vitro Dissolution Studiesmentioning

confidence: 98%

“…These results are in agreement with the findings reported earlier (21,22). Upon statistical evaluation (two-way ANOVA), a significant difference was observed between the test products (p < 0.01) but not within the test products for AUC (0)(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) , AUC (0-24) , AUC (0-∞) , t 1/2, K el and MRT values. Spearman rank correlation, a non-parametric statistical test, demonstrated a high degree of positive correlation, showing complete agreement in the order of ranks between the percentage of drug absorbed from patches and C max (p < 0.02; two tails), AUC (0-24) (p < 0.02; two tails) and AUC (0-∞) (p < 0.02; two tails).…”

Section: In Vivo Studies In Rabbitsmentioning

confidence: 99%

“…A Cygnus' sandwich patch holder, a slightly modified form of FDA's sandwich patch holder was used to ensure patch-to-patch reproducibility of transdermal films (10)(11)(12). The dissolution vessel contained 500 mL of phosphate buffer (pH 6.6) maintained at 32 ± 0.5°C (the skin surface temperature) and paddle speed was set at 50 rpm.…”

Section: In Vitro Dissolution Studiesmentioning

confidence: 99%

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Development of matrix controlled transdermal delivery systems of pentazocine: In vitro/in vivo performance

Verma

Chandak²

2009

Acta Pharmaceutica

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Transdermal drug delivery system is being extensively investigated as a viable alternative to drug delivery with improved bioavailability. It offers many advantages over conventional administration such as enhanced efficacy, increased safety, and greater convenience and improved patient compliance. Transdermal route permits the use of a relatively potent drug with minimal risk of systemic toxicity and avoids gastrointestinal degradation and hepatic first-pass metabolism (1-3). A number of therapeutic agents, including antihypertensive, antianginal, antihistaminic, anti-inflammatory, analgesic, The present study aimed to develop hydroxypropyl methylcellulose based transdermal delivery of pentazocine.In formulations containing lower proportions of polymer, the drug released followed the Higuchi kinetics while, with an increase in polymer content, it followed the zero-order release kinetics. Release exponent (n) values imply that the release of pentazocine from matrices was non-Fickian. FT-IR, DSC and XRD studies indicated no interaction between drug and polymer. The in vitro dissolution rate constant, dissolution half-life and pharmacokinetic parameters (C max , t max , AUC (s) , t 1/2, K el , and MRT) were evaluated statistically by two-way ANOVA. A significant difference was observed between but not within the tested products. Statistically, a good correlation was found between per cent of drug absorbed from patches vs. C max and AUC (s) . A good correlation was also observed when per cent drug released was correlated with the blood drug concentration obtained at the same time point. The results of this study indicate that the polymeric matrix films of pentazocine hold potential for transdermal drug delivery.Keywords: pentazocine, transdermal drug delivery, Cygnus' sandwich patch holder, in vitro characterization, in vivo evaluation * Correspondence; e-mail: prpverma275730@yahoo.com Unauthenticated Download Date | 8/28/18 7:56 PM and anti-arthritic drugs, are being investigated and developed for the transdermal therapeutic system either for academic research or for commercial purposes (3, 4). The present work is aimed at developing a matrix-dispersion type transdermal drug delivery of pentazocine.Pentazocine (PTZ), a benzomorphan derivative, is an opioid analgesic that has mixed opioid agonist and antagonist actions. It is considered to be a partial agonist or weak antagonist at the m-receptor and a k-receptor agonist. Pentazocine is used for relief of moderate to severe pain. Oral administration of PTZ has the disadvantage of low bioavailability (about 18-22 %) due to extensive first-pass metabolism (5-7). In addition, PTZ has a short half-life of 2-4 h and requires frequent dosing in order to maintain the optimal therapeutic concentration. Repeated injections over long periods may cause fibrotic changes in the skin and muscular tissue. Low molecular mass (285.4), suitable pK a values of 8.5 and 10, log P (octanol/phosphate buffer pH 7.4) of 2.0 and low oral bioavailability provide a rationale for developing a...

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Section: Dscmentioning

confidence: 95%

Section: In Vitro Dissolution Studiesmentioning

confidence: 98%

Section: In Vivo Studies In Rabbitsmentioning

confidence: 99%

Section: In Vitro Dissolution Studiesmentioning

confidence: 99%

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Development of matrix controlled transdermal delivery systems of pentazocine: In vitro/in vivo performance

Verma

Chandak²

2009

Acta Pharmaceutica

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“…Topical drug delivery is a useful painless route of drug administration, it offers an easy way for patients, and prevents the hepatic first pass metabolism of the drug (16,17). Within the major groups of a topical drug delivery system, the use of topical gel formulation has expanded in pharmaceutical field because of its favorable properties such as being thixotropic and greaseless, easily spreadable and removed, emollient and water soluble (18). Hydroxy propyl methyl cellulose (HPMC) is recommended in the gel formulation because of its nontoxic nature, ease of compression and good bioadhesiveness (19).…”

Section: Introductionmentioning

confidence: 99%

Formulation Development of a Topical Probiotic Gel for Antidermatophytosis Effect

Mehdi-Alamdarloo

Ameri

Moghimipour

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Topical drug delivery is a painless route of drug administration. Skin is one of the most easily accessible parts of human body for topical administration and also is a main route of topical drug delivery system. There are different skin diseases and infections caused by fungus. An antifungal compound is a pharmaceutical fungicide used to treat mycoses such as dermatophytes which have the ability to attack keratinized tissues and used keratin cause dermatophytosis, the most common human contagious fungal disease. Because of drug resistance, side effects and cytotoxicity associated with long-term treatment with antifungal drugs, finding new useful drugs to treat fungal infections is necessary.

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Lipid nanoparticles for topical and transdermal delivery of pharmaceuticals and cosmeceuticals

Sengar

Jyoti²,

Jain

et al. 2018

Lipid Nanocarriers for Drug Targeting

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Development and Evaluation of HPMC Based Matrices for Transdermal Patches of Tramadol

Cited by 21 publications

References 21 publications

Development of matrix controlled transdermal delivery systems of pentazocine: In vitro/in vivo performance

Development of matrix controlled transdermal delivery systems of pentazocine: In vitro/in vivo performance

Formulation Development of a Topical Probiotic Gel for Antidermatophytosis Effect

Lipid nanoparticles for topical and transdermal delivery of pharmaceuticals and cosmeceuticals

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