Development and evaluation of novel trans-buccoadhesive bilayer tablets of Famotidine

Alagusundaram, M; Dhachinamoorthi, D; Chetty, CMadhusudhana

doi:10.4103/0973-8398.91990

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…Fresh sheep buccal mucosa was used in an ex vivo diffusion investigation of Nifedipine formulations in a modified diffusion cell [ 37 ]. It was mounted between the donor and the receptor compartments with the fresh sheep buccal mucosa.…”

Section: Methodsmentioning

confidence: 99%

Development and Characterization of Gel-Based Buccoadhesive Bilayer Formulation of Nifedipine

Alagusundaram,

Jain,

Begum

et al. 2023

Gels

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A promising controlled drug delivery system has been developed based on polymeric buccoadhesive bilayered formulation that uses a drug-free backing layer and a polymeric hydrophilic gel buccoadhesive core layer containing nifedipine. The DSC thermogravimetric analysis confirms the drug’s entrapment in the gel layer and reveals no evidence of a potential interaction. Various ratios of bioadhesive polymers, including HPMC K100, PVP K30, SCMC, and CP 934, were combined with EC as an impermeable backing layer to ensure unidirectional drug release towards the buccal mucosa. The polymeric compositions of hydrophilic gel-natured HPMC, SCMC, and CP formed a matrix layer by surrounding the core nifedipine during compression. Preformulation studies were performed for all of the ingredients in order to evaluate their physical and flow characteristics. Ex vivo buccoadhesive strength, surface pH, swelling index, in vitro and in vivo drug release, and ex vivo permeation investigations were performed to evaluate the produced gel-based system. Rapid temperature variations had no appreciable impact on the substance’s physical properties, pharmacological content, or buccoadhesive strength during stability testing using actual human saliva. It was clear from a histological examination of the ex vivo mucosa that the developed system did not cause any irritation or inflammation at the site of administration. The formulation NT5 was the best one, with a correlation coefficient of 0.9966. The in vitro and in vivo drug release profiles were well correlated, and they mimic the in vitro drug release pattern via the biological membrane. Thus, the developed gel-based formulation was found to be novel, stable, and useful for the targeted delivery of nifedipine.

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Section: Methodsmentioning

confidence: 99%

Development and Characterization of Gel-Based Buccoadhesive Bilayer Formulation of Nifedipine

Alagusundaram,

Jain,

Begum

et al. 2023

Gels

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“…In the year 2019, high blood pressure was responsible for 54% of strokes, 47% of ischemic heart disease, 75% of hypertensive disease, and 25% of all cardiovascular disease worldwide. Hypertension has a demonstrable negative influence on health, especially when considering the disability, reduced quality of life, and mortality associated with stroke and cardiovascular disease [1,2].…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation sustained and immediate release bilayer tablet of telmisartan and amlodipine

Kumar

Verma

Islam

2022

ijhs

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The study was undertaken with the aim to Formulation and evaluation of bilayer tablet formulation of Telmisartan and Amlodipine. Thus, from the results, it is concluded that the formulation of immediate release layer of Amlodipine using 4-2% concentration of Crospovidone & PVA K30 and 30-20-1.5% concentration of HPMC K 100M-HPMC K4 M-HPMC K15 M are considered as ideal for optimized bilayer tablet formulation. The drug release data of the Telmisartan and Amlodipine was fitted into various kinetic models which as shown in figures 3.8 and 3.11. The order of release of drug was found to be zero order, in which R2 value was close to 1. The n value of Korsmeyer Peppas equation was found to be 0.746. Good correlation coefficients are obtained for Higuchi equation. The results showed that the formulation followed Peppas Model release. Thus, this optimized bilayer tablet formulation can be successfully used in the treatment of hypertension. This modified release bilayer tablets also reduced dosing frequency, increase the bioavailability and provide better patient compliance. From the results it was found that formulation F4 was the best formulation amongst the 5 formulations.

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“…The weight of water required to detach the tablet and patch, respectively, from buccal mucosa was noted as ex vivo mucoadhesive strength. Mucoadhesive strength was performed in duplicate, and average mucoadhesive strength was determined [23]. From this mucoadhesive strength, the force of adhesion was calculated using the following formula.…”

Section: Ex Vivo Mucoadhesive Strength and Force Of Adhesionmentioning

confidence: 99%

“…The pH was identified by bringing the electrode into contact with the tablet surface and allowing the surface to equilibrate for 1 min [23,24].…”

Section: Gawai and Zaheermentioning

confidence: 99%

Formualtion and Development of Mucoadhesive Sustained Release Buccal Tablets and Patches of 5-Fluorouracil Using Different Polymers

Gawai¹,

Zaheer

2018

Asian J Pharm Clin Res

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Objective: The present research study was undertaken to formulate mucoadhesive sustained release buccal tablets and patches of 5-fluorouracil (5-FU).Method: For the research experiment work design expert software version 10, stat-ease, Inc. has been used. A 3 2 full factorial design was selected for the formulation of the buccal tablet as well as buccal patches. In this research work, formulated tablets and patches using different polymers such as carbopol 974p, polyvinylpyrrolidone-K 30, sodium deoxycholate, microcrystalline cellulose, and polyvinyl alcohol. An after formulation of batches formulated products studied for characterization, namely, Fourier transform infrared (FTIR) and differential scanning calorimeter (DSC). Evaluation parameters studied such as weight uniformity, thickness, hardness, friability, and content uniformity also carried out. For drug release purpose from the formulation of buccal tablet and patches in vitro drug released performed. In vivo drug releases study also carried out using Rabbit for drug reaction point of view.Results: Design expert showed the significant results on independent and dependent variables. The R-Squared 0.9943 for drug release and 0.9985 for swelling index is in reasonable agreement with the formulations. FTIR and DSC indicating compatibility of the drug and polymers in the tablet formulation and patch formulations at the molecular level. The drug release of buccal tablet showed 75.10-99.34% and buccal patches showed 58.41-81.43%. These formulations showed good results when compared to the conventional tablet. Conclusion:Formulation of mucoadhesive sustained release buccal tablets and patches of 5-FU successfully done using different polymers, which would definitely help in increasing bioavailability of the drug.

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Development and evaluation of novel trans-buccoadhesive bilayer tablets of Famotidine

Cited by 6 publications

References 12 publications

Development and Characterization of Gel-Based Buccoadhesive Bilayer Formulation of Nifedipine

Development and Characterization of Gel-Based Buccoadhesive Bilayer Formulation of Nifedipine

Formulation and evaluation sustained and immediate release bilayer tablet of telmisartan and amlodipine

Formualtion and Development of Mucoadhesive Sustained Release Buccal Tablets and Patches of 5-Fluorouracil Using Different Polymers

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