Development and evaluation of organic silicon nanoparticles

Rosa, Rosana Letícia Da; Serbai, Luana; Novak, Robson Schimandeiro; Paula, Josiane de Fátima Padilha de; Toledo, Ana Cristina Oltramari; Carvalho, Vanessa Von Mühlen; Boscardin, Patrícia Mathias Doll

doi:10.34117/bjdv6n3-255

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Nanotechnology is a modern field of science that has applications in different fields of science, as in the pharmaceutical area with the objective of increasing the bioavailability of drugs, controlling the release at the site of action, decreasing toxicity, protecting the molecule from extrinsic and / or intrinsic factors and also facilitating the administration of medications (Banu et al, 2018;Rosa et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis and Characterization of Silver Nanoparticles Produced With Aqueous Extract of Pterodon Emarginatus Vogel - Fabaceae Seeds Associated With Gentamicin Sulfate and Hyaluronic Acid With Potential Antimicrobial Activity / Biossíntese E Caracterização De Nanopartículas De Prata Produzidas Com Extrato Aquoso De Sementes De Pterodon Emarginatus Vogel - Fabaceae Associadas Ao Sulfato De Gentamicina E Ao Ácido Hialurônico Com Potencial Atividade Antimicrobiana

Toledo

Assunção

Boscardin

et al. 2020

BJD

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Biosynthesis and characterization of silver nanoparticles produced with aqueous extract of Pterodon emarginatus Vogel -Fabaceae seeds associated with gentamicin sulfate and hyaluronic acid with potential antimicrobial activity Biossíntese e caracterização de nanopartículas de prata produzidas com extrato aquoso de sementes de Pterodon emarginatus Vogel -Fabaceae associadas ao sulfato de gentamicina e ao Ácido Hialurônico com potencial atividade antimicrobiana

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Section: Introductionmentioning

confidence: 99%

Biosynthesis and Characterization of Silver Nanoparticles Produced With Aqueous Extract of Pterodon Emarginatus Vogel - Fabaceae Seeds Associated With Gentamicin Sulfate and Hyaluronic Acid With Potential Antimicrobial Activity / Biossíntese E Caracterização De Nanopartículas De Prata Produzidas Com Extrato Aquoso De Sementes De Pterodon Emarginatus Vogel - Fabaceae Associadas Ao Sulfato De Gentamicina E Ao Ácido Hialurônico Com Potencial Atividade Antimicrobiana

Toledo

Assunção

Boscardin

et al. 2020

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Computational simulation of nanostructured lipid carrier containing lipids from Cupuassu (Theobroma grandiflorum) seed fat: Design, interaction and molecular dynamic study

Vieira

Silva

Brasil

et al. 2020

RSD

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Drug delivery systems are constantly evolving and developing, as well as the search for promising and effective formulations for drug delivery. Computational simulation methods enable the development of complex systems, such as nanostructured lipid carriers (NLC), the understanding of interaction and dynamics between drug molecule and its transporter. In this work, aimed to simulate a NLC containing cupuassu fat triacylglycerols, carnauba wax and caprylic/capric acid triacylglycerol, stabilized with Tween 80 and Pluronic and ketoconazole enantiomer as drug was simulated. Initially, lipid mixtures were studied by Differential Scanning Calorimetry and X-ray diffraction. Subsequently, computational studies were carried out, among which Molecular Docking of ketoconazole to the lipid mixture and Molecular Dynamics of NLC system containing ketoconazole. From the results obtained it was possible to observe the main binding affinities of the drug and provide a better NLC formulation. It was also possible to propose a three-dimensional NLC model that was stable after molecular dynamics and ideal for future experimental studies.

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Development and evaluation of organic silicon nanoparticles

Abstract: Development and evaluation of organic silicon nanoparticles Desenvolvimento e avaliação de nanopartículas de silício orgânico

Cited by 2 publications

References 8 publications

Computational simulation of nanostructured lipid carrier containing lipids from Cupuassu (Theobroma grandiflorum) seed fat: Design, interaction and molecular dynamic study

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