Development and evaluation of pH-dependent interpenetrating network of acrylic acid/polyvinyl alcohol

Shah, Shahid; Ranjha, Nazar Muhammad; Javaid, Zeeshan

doi:10.1007/s13726-013-0180-0

Cited by 18 publications

(7 citation statements)

References 24 publications

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“…It was observed that, at higher concentration of cross-linker, the relaxation of polymer chain decreased which is responsible for the less swelling of hydrogel. Same results were found by Shah et al [23].…”

Section: Effect Of Degree Of Cross-linking On Swelling and Onsupporting

confidence: 87%

“…According to this theory, values increase as the swelling ratio of hydrogels increased. Molecular weight between adjacent cross-links is calculated by using [23]…”

Section: Molecular Weight Between Cross-links ( ) Flory-mentioning

confidence: 99%

“…where represents the fraction of drug release in time and 2 is the Higuchi constant. Korsmeyer-Peppas model [23] is as follows:…”

Section: Drug Release Studymentioning

confidence: 99%

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Synthesis and Characterization of Chemically Cross-Linked Acrylic Acid/Gelatin Hydrogels: Effect of pH and Composition on Swelling and Drug Release

Bukhari

Khan

Rehanullah

et al. 2015

International Journal of Polymer Science

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170

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This present work was aimed at synthesizing pH-sensitive cross-linked AA/Gelatin hydrogels by free radical polymerization. Ammonium persulfate and ethylene glycol dimethacrylate (EGDMA) were used as initiator and as cross-linking agent, respectively. Different feed ratios of acrylic acid, gelatin, and EGDMA were used to investigate the effect of monomer, polymer, and degree of cross-linking on swelling and release pattern of the model drug. The swelling behavior of the hydrogel samples was studied in 0.05 M USP phosphate buffer solutions of various pH values pH 1.2, pH 5.5, pH 6.5, and pH 7.5. The prepared samples were evaluated for porosity and sol-gel fraction analysis. Pheniramine maleate used for allergy treatment was loaded as model drug in selected samples. The release study of the drug was investigated in 0.05 M USP phosphate buffer of varying pH values (1.2, 5.5, and 7.5) for 12 hrs. The release data was fitted to various kinetic models to study the release mechanism. Hydrogels were characterized by Fourier transformed infrared (FTIR) spectroscopy which confirmed formation of structure. Surface morphology of unloaded and loaded samples was studied by surface electron microscopy (SEM), which confirmed the distribution of model drug in the gel network.

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Section: Effect Of Degree Of Cross-linking On Swelling and Onsupporting

confidence: 87%

“…According to this theory, values increase as the swelling ratio of hydrogels increased. Molecular weight between adjacent cross-links is calculated by using [23]…”

Section: Molecular Weight Between Cross-links ( ) Flory-mentioning

confidence: 99%

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Synthesis and Characterization of Chemically Cross-Linked Acrylic Acid/Gelatin Hydrogels: Effect of pH and Composition on Swelling and Drug Release

Bukhari

Khan

Rehanullah

et al. 2015

International Journal of Polymer Science

Self Cite

170

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“…For sol‐gel fraction analysis, the dried PAA samples were subjected to Soxhlet extraction using DIW as the solvent at 100 °C for 12 h. Extracted gels were dried again. The gel fraction was calculated from the masses of the initial dry gel ( W i ) and the extracted dry gel ( W f ) :

true Sol fraction (() %) = ([], \frac{W_{i} - W_{f}}{W_{i}}) \times 100

true Gel fraction (() %) = 100 - Sol fraction

…”

Section: Methodsmentioning

confidence: 99%

Effects of Crosslinker Concentration in Poly(Acrylic Acid)‐KOH Gel Electrolyte on Performance of Zinc‐Air Batteries

Tran

Clark

Chung

et al. 2020

Batteries & Supercaps

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Zinc-air batteries (ZABs) using gel polymer electrolytes suffer from low energy efficiency and poor cyclability. This issue is not only associated with the air electrode, as early failure of the battery is often due to the Zn electrode. Here, the cycle life of ZABs using alkaline poly(acrylic acid) (PAA-KOH) as the electrolyte is shown to vary by changing its crosslinking density. For ZABs using hydrogel electrolytes, understanding the failure mechanism and optimization of the hydrogel composition are key to achieving better utilization of the Zn electrode and battery rechargeability. In addition, the effects of crosslinker concentration on rheological properties, sol-gel fraction, ionic conductivity, and water retention ability of the hydrogel are discussed. PAA-KOH gels with lower crosslinking concentrations are weaker, but they have higher conductivity and better water retention, whereas gels with higher crosslinking concentrations affect the diffusion of zincate ions and facilitate passivation of the Zn electrode, resulting in early failure of the battery.[a] T.

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“…Diffusion coefficient refers to the quantity of substance diffusing through a concentration gradient across the unit area in unit time. The following equation was used for the calculation of water diffusion coefficients of hydrogels [36].…”

Section: Preparation Of Hybrid Polymeric Network Of Polymentioning

confidence: 99%

Highly Porous pH-Responsive Carboxymethyl Chitosan-Grafted-Poly (Acrylic Acid) Based Smart Hydrogels for 5-Fluorouracil Controlled Delivery and Colon Targeting

Khan

Anwar

2019

International Journal of Polymer Science

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In the present investigation, new formulations of CMCS/AA hydrogels with varying composition of Carboxymethyl chitosan, acrylic acid, and ethylene glycol dimethacrylate (EGDMA) were prepared by free radical polymerization technique using benzoyl peroxide as catalyst. The bioavailability of 5-FU through the oral route is very limited owing to its rapid metabolism and clearance from the general circulation. Current work was aimed at increasing the bioavailability of 5-FU via smart hydrogels and at investigating their potential in delivering 5-FU to target colon cancer. Swelling studies were carried out on dried hydrogel discs in different USP phosphate buffer solutions of various pH values. Porosity and gel fraction of all the samples were measured. 5-FU was used as a model drug and loaded in selected hydrogel samples. The amount of drug loaded and released was determined. Experimental data was fitted to various model equations, and corresponding parameters were calculated to study the release mechanism. Many structural parameters were calculated. The prepared hydrogels were also characterized by FTIR and SEM to study the structure, crystallinity, compatibility, and morphology of the smart hydrogels. The biocompatibility and cytotoxic potential blank and drug-loaded hydrogels were assessed through MTT assay. The prepared hydrogels were found to be an excellent carrier for 5-FU in targeting colon cancer.

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Development and evaluation of pH-dependent interpenetrating network of acrylic acid/polyvinyl alcohol

Cited by 18 publications

References 24 publications

Synthesis and Characterization of Chemically Cross-Linked Acrylic Acid/Gelatin Hydrogels: Effect of pH and Composition on Swelling and Drug Release

Synthesis and Characterization of Chemically Cross-Linked Acrylic Acid/Gelatin Hydrogels: Effect of pH and Composition on Swelling and Drug Release

Effects of Crosslinker Concentration in Poly(Acrylic Acid)‐KOH Gel Electrolyte on Performance of Zinc‐Air Batteries

Highly Porous pH-Responsive Carboxymethyl Chitosan-Grafted-Poly (Acrylic Acid) Based Smart Hydrogels for 5-Fluorouracil Controlled Delivery and Colon Targeting

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