Development and evaluation of polymeric nanocapsules for cirsiliol isolated from Jordanian Teucrium polium L. as a potential anticancer nanomedicine

Al‐Shalabi, Eveen; Alkhaldi, Muzn; Sunoqrot, Suhair

doi:10.1016/j.jddst.2020.101544

Cited by 19 publications

(29 citation statements)

References 37 publications

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“…Various vegetable oils and triglycerides may be employed to form oil-cored NC [ 32 ]. In this study, castor oil was used as it has previously demonstrated superior ability to solubilize various polyphenolic and aromatic drug molecules during NC formation [ 25 , 33 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…Oil-filled core-shell TQ NC were prepared by nanoprecipitation as reported in our earlier publication [ 25 ]. The organic phase was a solvent mixture of acetone and ethanol (60:40, v / v ) containing mPEG-PCL (25 mg), castor oil (150 µL), TQ (2.5 mg), and Span 80 (25 mg).…”

Section: Methodsmentioning

confidence: 99%

“…TQ release was investigated in phosphate buffer (pH 7.4) and acetate buffer (pH 5.0) to simulate physiologic and lysosomal/tumor microenvironment pH, respectively. All release media contained 0.5% w/v Tween 80 to ensure sink conditions [ 25 , 26 , 27 , 28 ]. For the release test, triplicate samples of freshly prepared NPs (1 mL) were each transferred to a dialysis bag with 12–14 kD MWCO (Spectrum laboratories Inc., Rancho Dominguez, CA, USA) and immersed in 30 mL release media in tightly closed glass vials.…”

Section: Methodsmentioning

confidence: 99%

“…mPEG-PCL can be synthesized with varying chain lengths of the biodegradable block (i.e., PCL) in order to modulate its physicochemical properties. It can also be used to prepare NPs with different architectures such as matrix-type nanospheres (NS) [ 24 ], reservoir-type (core/shell) nanocapsules (NC) [ 25 ], as well as polymeric micelles [ 26 ]. In this study, in order to reach an optimized NP formulation for TQ, mPEG-PCL NPs were fabricated using different PCL chain lengths in the form of matrix-type NS or reservoir-type NC.…”

Section: Introductionmentioning

confidence: 99%

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Development of a Thymoquinone Polymeric Anticancer Nanomedicine through Optimization of Polymer Molecular Weight and Nanoparticle Architecture

et al. 2020

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Thymoquinone (TQ) is a water-insoluble natural compound isolated from Nigella sativa that has demonstrated promising chemotherapeutic activity. The purpose of this study was to develop a polymeric nanoscale formulation for TQ to circumvent its delivery challenges. TQ-encapsulated nanoparticles (NPs) were fabricated using methoxy poly(ethylene glycol)-b-poly(ε-caprolactone) (mPEG-PCL) copolymers by the nanoprecipitation technique. Formulation variables included PCL chain length and NP architecture (matrix-type nanospheres or reservoir-type nanocapsules). The formulations were characterized in terms of their particle size, polydispersity index (PDI), drug loading efficiency, and drug release. An optimized TQ NP formulation in the form of oil-filled nanocapsules (F2-NC) was obtained with a mean hydrodynamic diameter of 117 nm, PDI of 0.16, about 60% loading efficiency, and sustained in vitro drug release. The formulation was then tested in cultured human cancer cell lines to verify its antiproliferative efficacy as a potential anticancer nanomedicine. A pilot pharmacokinetic study was also carried out in healthy mice to evaluate the oral bioavailability of the optimized formulation, which revealed a significant increase in the maximum plasma concentration (Cmax) and a 1.3-fold increase in bioavailability compared to free TQ. Our findings demonstrate that the versatility of polymeric NPs can be effectively applied to design a nanoscale delivery platform for TQ that can overcome its biopharmaceutical limitations.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of a Thymoquinone Polymeric Anticancer Nanomedicine through Optimization of Polymer Molecular Weight and Nanoparticle Architecture

et al. 2020

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“…Despite its promising therapeutic benefits, cirsiliol has not yet been formulated into any type of dosage form. Thus, to enhance its biopharmaceutical properties, Al-Shalabi et al [ 137 ] developed a polymeric nanoscale formulation for cirsiliol isolated from Jordanian Teucrium polium L. ( T. polium , germander). Cirsiliol entrapped into core-shell NPs composed of castor oil-filled core and poly(ethylene glycol)-b-poly(ε-caprolactone), showing a mean diameter of 158.1 nm and an almost neutral surface charge, exhibited an EE of 53.5%, as well as a sustained drug release at pH 7.4, with 41% of cirsiliol released after four days.…”

Section: Nanoformulations Involving Vegetable Oil-based Nutraceutimentioning

confidence: 99%

Nutraceutical Vegetable Oil Nanoformulations for Prevention and Management of Diseases

Vergallo

2020

Nanomaterials

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The scientific community is becoming increasingly interested in identifying, characterizing, and delivering nutraceuticals, which constitutes a multi-billion-dollar business. These bioactive agents are claimed to exhibit several health benefits, including the prevention and treatment of diseases such as arthritis, cancer, osteoporosis, cataracts, Alzheimer’s, and Huntington’s diseases, heart, brain and metabolic disorders, etc. Nutraceuticals are typically consumed as part of a regular human diet and are usually present within foods, comprising vegetable oil, although at low levels and variable composition. Thus, it is difficult to control the type, amount and frequency of their ingestion by individuals. Nanoformulations about vegetable oil-based bioactive compounds with nutraceutical properties are useful for overcoming these issues, while improving the uptake, absorption, and bioavailability in the body. The purpose of this current study is to review papers on such nanoformulations, particularly those relevant for health benefits and the prevention and management of diseases, as well as bioactives extracted from vegetable oils enhancing the drug effectiveness, retrieved through bibliographic databases by setting a timespan from January 2000 to April 2020 (about 1758 records).

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A Comprehensive Review on Core‐Shell Polymeric Particles for Enzyme Immobilization

et al. 2022

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The search for ideal solid support that promotes enzyme stability, easy separation and reuse cycles in different processes has grown widely. In this sense, core‐shell polymer particles draw attention because they are already widely used in adsorption, catalysis, and drug delivery, due to their remarkable advantages in surface properties adjustment, excellent mechanical stability, and high chemical resistance, as a result of the combination of the characteristics of the polymers that form the core and shell of the structure. Thus, this review article provides an overview of the synthesis processes of these particles, highlighting the characteristics that can be obtained from each synthesis technique, as well as the most recently used techniques to obtain polymeric particles with core‐shell morphology. The advantages and main challenges for the application of these structures in the immobilization of enzymes are also discussed, providing a general summary of what has been explored in the literature. Despite the potential of application, the use of these materials in the immobilization of enzymes is still little explored, with studies focused mainly on lipases and around the same classes of polymers. Therefore, there is an opportunity window regarding the investigation of the immobilization of other enzymes of commercial interest on these polymeric supports.

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Development and evaluation of polymeric nanocapsules for cirsiliol isolated from Jordanian Teucrium polium L. as a potential anticancer nanomedicine

Cited by 19 publications

References 37 publications

Development of a Thymoquinone Polymeric Anticancer Nanomedicine through Optimization of Polymer Molecular Weight and Nanoparticle Architecture

Development of a Thymoquinone Polymeric Anticancer Nanomedicine through Optimization of Polymer Molecular Weight and Nanoparticle Architecture

Nutraceutical Vegetable Oil Nanoformulations for Prevention and Management of Diseases

A Comprehensive Review on Core‐Shell Polymeric Particles for Enzyme Immobilization

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