Development and Evaluation of Two Live <i>Salmonella</i>-Vectored Vaccines for <i>Campylobacter</i> Control in Broiler Chickens

Adams, Lindsay Jones; Zeng, Xianying; Lin, Jun

doi:10.1089/fpd.2018.2561

Cited by 10 publications

(7 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multiple trials have been conducted testing the effect of vaccination to induce an effective control of Campylobacter (Jones Adams et al, 2019;Meunier et al, 2016Meunier et al, , 2017Wang et al, 2020). However, this strategy presents some drawbacks that limit its use, such as the genotypic variation of Campylobacter strains (Zbrun et al, 2017) and the choice and presentation of antigen (de Zoete et al, 2007;Walles et al, 2019).…”

Section: Probiotic Supplementationmentioning

confidence: 99%

Impact of farm‐level strategies against thermotolerant Campylobacter in broiler chickens, using a quantitative risk assessment model and meta‐analysis

Zbrun

Olivero

Soto

et al. 2022

Zoonoses and Public Health

View full text Add to dashboard Cite

The aim of this study was to evaluate the effect of control strategies (probiotic supplementation and vaccination) at farm on thermotolerant Campylobacter infection due to the consumption of salad cross‐contaminated from broiler meat. The broiler food chain was modelled considering the most common practices applied in Argentina (baseline model) and their effect on the prevalence and counts of Campylobacter. Probiotic supplementation and vaccination against Campylobacter spp. were included in different models to evaluate their effectiveness. The parameter distributions of each intervention were obtained based on a systematic review and meta‐analysis previously described. The control measures applied at farms were evaluated considering their effectiveness in reducing both the prevalence and the count of thermotolerant Campylobacter in comparison with the baseline model estimation and expressed as relative change in campylobacteriosis risk. Additionally, the identification of the most important input parameters for the model was performed by sensitivity analysis. The model estimated a risk of campylobacteriosis per consumed serving of salad contaminated with poultry meat of 4.99 x 10–3 (95% CI: 6.12 x 10–6–1.13 x 10–2), corresponding to an annual incidence risk estimated of 1,876,009 persons. Scenario analysis indicated that the application of vaccines against Campylobacter (probability of campylobacteriosis = 9.55 x 10–4; 95% CI: 5.31 x 10–4–1.29 x 10–3) and the supplementation of broilers with probiotics (probability of campylobacteriosis = 1.32 x 10–3; 8.55 x 10–4–1.69 x 10–3) can offer a modest reduction in risk estimates. The intervention efficacy was 80.86% and 73.54% for vaccination and probiotic supplementation, respectively. On‐farm interventions were effective to mitigate the risk of campylobacteriosis.

show abstract

Section: Probiotic Supplementationmentioning

confidence: 99%

Impact of farm‐level strategies against thermotolerant Campylobacter in broiler chickens, using a quantitative risk assessment model and meta‐analysis

Zbrun

Olivero

Soto

et al. 2022

Zoonoses and Public Health

View full text Add to dashboard Cite

show abstract

“…Vandeputte et al (2019) reported that in ovo-vaccinated birds using vaccines based on maternal antibodies were not protected with the treated birds showing similar caecal C. Jejuni concentrations to the control birds. Adams et al (2019) developed and tested live-attenuated Salmonella-vectored vaccines but found that oral vaccination of the broilers failed to trigger significant systemic and intestinal mucosal immune responses and hence did not confer protection against C. jejuni.…”

Section: Vaccinationmentioning

confidence: 99%

“…Adams et al. () developed and tested live‐attenuated Salmonella ‐vectored vaccines but found that oral vaccination of the broilers failed to trigger significant systemic and intestinal mucosal immune responses and hence did not confer protection against C. jejuni .…”

Section: Assessmentmentioning

confidence: 99%

Update and review of control options for Campylobacter in broilers at primary production

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2020

EFS2

View full text Add to dashboard Cite

The 2011 EFSA opinion on Campylobacter was updated using more recent scientific data. The relative risk reduction in EU human campylobacteriosis attributable to broiler meat was estimated for on‐farm control options using Population Attributable Fractions (PAF) for interventions that reduce Campylobacter flock prevalence, updating the modelling approach for interventions that reduce caecal concentrations and reviewing scientific literature. According to the PAF analyses calculated for six control options, the mean relative risk reductions that could be achieved by adoption of each of these six control options individually are estimated to be substantial but the width of the confidence intervals of all control options indicates a high degree of uncertainty in the specific risk reduction potentials. The updated model resulted in lower estimates of impact than the model used in the previous opinion. A 3‐log10 reduction in broiler caecal concentrations was estimated to reduce the relative EU risk of human campylobacteriosis attributable to broiler meat by 58% compared to an estimate larger than 90% in the previous opinion. Expert Knowledge Elicitation was used to rank control options, for weighting and integrating different evidence streams and assess uncertainties. Medians of the relative risk reductions of selected control options had largely overlapping probability intervals, so the rank order was uncertain: vaccination 27% (90% probability interval (PI) 4–74%); feed and water additives 24% (90% PI 4–60%); discontinued thinning 18% (90% PI 5–65%); employing few and well‐trained staff 16% (90% PI 5–45%); avoiding drinkers that allow standing water 15% (90% PI 4–53%); addition of disinfectants to drinking water 14% (90% PI 3–36%); hygienic anterooms 12% (90% PI 3–50%); designated tools per broiler house 7% (90% PI 1–18%). It is not possible to quantify the effects of combined control activities because the evidence‐derived estimates are inter‐dependent and there is a high level of uncertainty associated with each.

show abstract

“…Based on the full-text evaluation using the prevalence of colonized chickens, 75 of 120 trials (85.0%) were excluded. The majority of the excluded trials were vaccine trials using a seeder colonization challenge model (n = 22), followed by data of number of individual colonized broiler not reported or unable to estimate from figures (n = 18), immune responses reported (n = 18), vaccine efficacy evaluated from ileum and cloaca (n = 15; 4 articles) [22,28,44,45], and trials using co-administration of vaccine and probiotics (n = 2; 1 article) [46]. The remaining 45 trials (10.1%) from 13 articles fulfilled the selection criteria and were included in the systematic review.…”

Section: Eligibilitymentioning

confidence: 99%

A Systematic Review of Campylobacter jejuni Vaccine Candidates for Chickens

et al. 2021

View full text Add to dashboard Cite

Campylobacter jejuni infection linked to the consumption of contaminated poultry products is one of the leading causes of human enteric illness worldwide. Vaccination of chickens is one of the potential strategies that could be used to control C. jejuni colonization. To date, various C. jejuni vaccines using potential antigens have been evaluated, but a challenge in identifying the most effective formulation is the wide variability in vaccine efficacies reported. A systematic review was undertaken to compare C. jejuni vaccine studies. Based upon specific selection criteria eligible papers were identified and included in the analysis. Vaccine efficacy reported from different C. jejuni antigens, vaccine types, and vaccination regimens reported in these papers were reviewed. Our analysis shows that total outer membrane proteins and cysteine ABC transporter substrate-binding protein were among the most efficacious vaccine antigen candidates reported. This review also highlights the importance of the need for increased consistency in the way C. jejuni vaccine studies in poultry are designed and reported in order to be able to undertake a robust comparison of C. jejuni vaccine candidates.

show abstract

Development and Evaluation of Two Live Salmonella-Vectored Vaccines for Campylobacter Control in Broiler Chickens

Cited by 10 publications

References 28 publications

Impact of farm‐level strategies against thermotolerant Campylobacter in broiler chickens, using a quantitative risk assessment model and meta‐analysis

Impact of farm‐level strategies against thermotolerant Campylobacter in broiler chickens, using a quantitative risk assessment model and meta‐analysis

Update and review of control options for Campylobacter in broilers at primary production

A Systematic Review of Campylobacter jejuni Vaccine Candidates for Chickens

Contact Info

Product

Resources

About