Development and evolution of the neural crest: An overview

Bronner‐Fraser, Marianne; LeDouarin, Nicole M.

doi:10.1016/j.ydbio.2011.12.042

Cited by 330 publications

(285 citation statements)

References 57 publications

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“…Growth factor signaling in CNCCs regulates the patterning and growth of facial primordia (21,27,28). Although it has been widely recognized that primary cilia are projected like antennas and serve as either chemosensory or mechanosensory organelles, their role in CNCCs remains unclear.…”

Section: Ift20 Is Essential For Assembling Primary Cilia That Transdumentioning

confidence: 99%

“…Disrupting ciliogenic components in cranial neural crest cells (CNCCs) frequently results in embryonic and/or postnatal craniofacial abnormalities (25,26), indicating a tight relationship between primary cilia and craniofacial morphogenesis. Because CNCCs are multipotent stem cells essential for forming craniofacial skeletal components (27,28), it is important to understand how primary cilia function in CNCCc during facial development.…”

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confidence: 99%

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Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development

Noda¹,

Kitami²,

Kitami

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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The primary cilium is a cellular organelle that coordinates signaling pathways critical for cell proliferation, differentiation, survival, and homeostasis. Intraflagellar transport (IFT) plays a pivotal role in assembling primary cilia. Disruption and/or dysfunction of IFT components can cause multiple diseases, including skeletal dysplasia. However, the mechanism by which IFT regulates skeletogenesis remains elusive. Here, we show that a neural crest-specific deletion of intraflagellar transport 20 (Ift20) in mice compromises ciliogenesis and intracellular transport of collagen, which leads to osteopenia in the facial region. Whereas platelet-derived growth factor receptor alpha (PDGFRα) was present on the surface of primary cilia in wildtype osteoblasts, disruption of Ift20 down-regulated PDGFRα production, which caused suppression of PDGF-Akt signaling, resulting in decreased osteogenic proliferation and increased cell death. Although osteogenic differentiation in cranial neural crest (CNC)-derived cells occurred normally in Ift20-mutant cells, the process of mineralization was severely attenuated due to delayed secretion of type I collagen. In control osteoblasts, procollagen was easily transported from the endoplasmic reticulum (ER) to the Golgi apparatus. By contrast, despite having similar levels of collagen type 1 alpha 1 (Col1a1) expression, Ift20 mutants did not secrete procollagen because of dysfunctional ER-to-Golgi trafficking. These data suggest that in the multipotent stem cells of CNCs, IFT20 is indispensable for regulating not only ciliogenesis but also collagen intracellular trafficking. Our study introduces a unique perspective on the canonical and noncanonical functions of IFT20 in craniofacial skeletal development.cranial neural crest cells | intracellular trafficking | intraflagellar transport | PDGF signaling | primary cilia

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Section: Ift20 Is Essential For Assembling Primary Cilia That Transdumentioning

confidence: 99%

mentioning

confidence: 99%

Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development

Noda¹,

Kitami²,

Kitami

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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“…In this model, donor quail tissues were grafted into similar regions of developing chicken embryos (13). The experimental approach of our present study was based on the generation of mouse-mouse NC chimeras that had been created by injection of primary mouse NCCs into the amniotic cavity of embryonic-day (E) 8.5 embryos (14,15).…”

mentioning

confidence: 99%

Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos

Cohen

Wert

Goldmann

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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The neural crest (NC) represents multipotent cells that arise at the interphase between ectoderm and prospective epidermis of the neurulating embryo. The NC has major clinical relevance because it is involved in both inherited and acquired developmental abnormalities. The aim of this study was to establish an experimental platform that would allow for the integration of human NC cells (hNCCs) into the gastrulating mouse embryo. NCCs were derived from pluripotent mouse, rat, and human cells and microinjected into embryonic-day-8.5 embryos. To facilitate integration of the NCCs, we used recipient embryos that carried a c-Kit mutation (W sh /W sh ), which leads to a loss of melanoblasts and thus eliminates competition from the endogenous host cells. The donor NCCs migrated along the dorsolateral migration routes in the recipient embryos. Postnatal mice derived from injected embryos displayed pigmented hair, demonstrating differentiation of the NCCs into functional melanocytes. Although the contribution of human cells to pigmentation in the host was lower than that of mouse or rat donor cells, our results indicate that hNCCs, injected in utero, can integrate into the embryo and form mature functional cells in the animal. This mouse-human chimeric platform allows for a new approach to study NC development and diseases.human neural crest cells | chimera | embryonic stem cells | melanocytes

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“…During embryogenesis, neural crest cells undergo an epithelio mesenchymal transition to yield migratory cells dispersing along specific pathways, then they differentiate into various cell types, including neurons, glial cells of the nervous system, endocrine cells and melanocytes [28,29]. Several studies have shown that murine melanoblasts undergo proliferation before migration through the somites and between the dermatome and overlying ectoderm.…”

Section: Neural Crest Origin Of Melanoblasts Premelanocytes and Melamentioning

confidence: 99%

Distribution and Extracellular Matrix Environment of Premelanoblasts during Skin Development in Xiphophorus Hybrids

Ku¹,

El-Hashash²

2017

Anat Physiol

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Neural crest cells give rise to melanoblasts that invade the dermis and epidermis to differentiate into melanocytes that can develop melanoma, which is one of the most aggressive forms of human cancer. Identification of mechanisms important for the initial development of melanoma is hampered because of the difficulty in studying them in transgenic mice with melanoma. In addition, there is only fragmentary knowledge about the histochemical and biochemical changes that accompany the very early stages of neural crest/premelanoblast invasion into the skin, which may later develop melanoma, in the naturally occurring melanoma models such as Xiphophorus fish hybrids. Herein, we used Xiphophorus hybrid fish to investigate the distribution and extracellular matrix (ECM) environment of premelanoblasts during early stages of skin development, and to test the hypothesis that there are parallels between neural crest/premelanoblast invasion and ECM changes in the early developing skin. To test this hypothesis, we investigated neural crest/premelanoblast cell distribution through development and characterize their ECM environment. We found several histochemical evidences for the correlation between this pattern of developing skin invasion by neural crest cells/premelanoblasts and the spatiotemporal relationship of extracellular matrix components that stimulate cell migration/invasion such as collagen, and others such as non-sulfated glycosaminoglycan that may facilitate cell invasion by enhancing the intercellular spaces and inhibition of extensive intercellular interactions by physically separating cells. These findings help to uncover some histochemical and biochemical changes that accompany the early stages of skin formation in Xiphophorus fish hybrids, and can also provide a conceptual framework for future mechanistic studies in this area, and for studies that use this fish hybrid as a naturally occurring melanoma model.

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Development and evolution of the neural crest: An overview

Cited by 330 publications

References 57 publications

Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development

Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development

Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos

Distribution and Extracellular Matrix Environment of Premelanoblasts during Skin Development in Xiphophorus Hybrids

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