Development and External Validation of a New Outcome Prediction Model for Patients With Clear Cell Renal Cell Carcinoma Treated With Nephrectomy Based on Preoperative Serum C-Reactive Protein and TNM Classification: The TNM-C Score

Iimura, Yasumasa; Saito, Kazutaka; Fujii, Yasuhisa; Kumagai, Jun; Kawakami, Satoru; Komai, Yoshinobu; Yonese, Junji; Fukui, Iwao; Kihara, Kazunori

doi:10.1016/j.juro.2008.10.156

Cited by 87 publications

(72 citation statements)

References 19 publications

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“…This conclusion is correlated with other researches (Guo et al, 2013;Yu et al, 2013;Hu et al, 2014). A new predictive model that includes CRP and TNM stage has been developed to evaluate the prognosis of clear cell renal cell carcinoma (Iimura et al, 2009).…”

Section: Discussionsupporting

confidence: 80%

Prognostic Value of C-Reactive Protein in Esophageal Cancer: a Meta-analysis

Zheng

Cao²,

Cui³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The classical inflammatory biomarker, C-reactive protein (CRP), has been identified to be related to progression of esophageal cancer. Some research showed that elevated pretreatment serum CRP indicated a poor prognosis, but results have been inconsistent. Materials and Methods: We searched the Medline, Embase and the Cochrane Central Search Library for suitable studies and a meta-analysis of eleven (1,886 patients) was conducted to examine the relationship between elevated serum CRP level and overall survival (OS) in esophageal cancer cases. Moreover, correlation analyses were conducted to assess links between pretreatment serum CRP level and tumor node metastasis (TNM) stage as well as T, N, M grade, respectively. Results: The pooled analysis showed that elevated pretreatment serum CRP level was significantly associated with poorer overall survival (HR 2.09, 95%CI 1.52-2.87, p<0.01). Subgroup analyses were conducted by "country", "cut-off value", "treatment" and "number of patients", and no single factor could alter the result. Elevated pretreatment serum CRP was significantly correlated with more advanced TNM stage and T, N, M grade respectively. Conclusions: Elevated pretreatment serum CRP levels are associated with poorer prognosis in esophageal cancer patients, and could serve as a useful biomarker for outcome prediction.

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Section: Discussionsupporting

confidence: 80%

Prognostic Value of C-Reactive Protein in Esophageal Cancer: a Meta-analysis

Zheng

Cao²,

Cui³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…43 Absolute preoperative CRP as a continuous variable is also a good predictor of metastasis and mortality 1 year after surgery in clinically localized RCC patients. 44 The prognostic significance of CRP has been shown with its power for improving the combined predictive accuracy of established markers and prediction models through multivariable statistics 46,47 in a manner consistent with a criterion proposed by Kattan. 58 In a study by Karakiewicz et al that included 314 patients with any stage of RCC, CRP improved the predictive accuracy by 3.7% for RCC-specific mortality.…”

Section: Prognostic Value Of Crp In Renal Cell Carcinomamentioning

confidence: 76%

Role of C‐reactive protein in urological cancers: A useful biomarker for predicting outcomes

Saito

Kihara

2012

Int J of Urology

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Abbreviations & AcronymsAbstract: Based on increasing evidence of the association between cancer-related inflammation and the progression of cancer, the external symptoms of systemic inflammatory response has been shown to be an indicator for the prognosis of many malignancies, including urological cancers. C-reactive protein, a representative acute-phase reactant, is a significant and sensitive inflammatory marker that can be objectively measured using reliable assays in clinical practice worldwide. C-reactive protein has been shown to be significant in the prediction of outcomes of urological cancers. The elevation of C-reactive protein levels, which indicate the presence of cancer-associated systemic inflammatory response, is linked to poorer survival in patients with urological cancers, including renal cell carcinoma, upper urinary tract and bladder cancers, and prostate cancer. With this strong prognostic ability, C-reactive protein can be incorporated into prognostic models and will make them simpler and improve their predictive accuracy. Furthermore, the longitudinal change of C-reactive protein level, C-reactive protein kinetics, provides additional information on patient survival outcomes. As such, C-reactive protein can be used to monitor treatment efficacy and disease course using serial measurements. In testicular cancer, C-reactive protein is associated with a risk of late complications, such as cardiovascular disease, and with the development of second non-germ-cell cancer. Taken together, these findings show that C-reactive protein can act as an important biomarker for urological cancers. This review discusses the importance of C-reactive protein as a prognostic biomarker in urological cancers on the basis of the currently available evidence.

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“…Multivariate survival analysis with calculation of hazard ratio (HR) with 95% confidence interval (CI) was performed using the Cox proportional hazards model including all covariates that were significant on univariate analysis. We applied a weighting method to each variable (14); the coefficient for each factor was divided by the highest coefficient, multiplied by 4, and rounded to the nearest integer (15). Precision of the reported coefficients was assessed by creating 1,000 bootstrap samples from the entire data set and replicating the estimation process.…”

Section: Discussionmentioning

confidence: 99%

Preoperative serum albumin as a prognostic factor in patients with upper urinary tract urothelial carcinoma

Kim

Choi

et al. 2014

Int. braz j urol.

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ARTICLE INFO ______________________________________________________________ ______________________Purpose: The study evaluated whether preoperative measures of the C-reactive protein--based systemic inflammatory response may predict cancer survival independent of tumor stage in patients with upper urinary tract urothelial carcinoma (UTUC). Materials and Methods:Between September 1999 and October 2010, 181 patients submitted to radical nephroureterectomy were available for evaluation. Multivariate survival analyses were performed using Cox's proportional hazards model and the coefficient for each factor was divided by the highest coefficient, multiplied by 4, and rounded to the nearest integer.Results: Multivariate analyses showed that tumor location, pathologic T stage, lymphovascular invasion, margin status, and albumin level were independent contributors. The bootstrap-corrected C statistics of the model were 0.813 for disease-specific survival and 0.755 for overall survival, respectively. For time to disease-specific and overall mortality for patients, integrated area under the curve values were 0.792 and 0.739, respectively. When patients were clustered into three groups according to their model--predicted survival, the 5-year disease-specific survival in the low-, intermediate-and high-risk group was 95.4%, 76.2%, and 36.9%, respectively (p<0.001), and were 87.8%, 54.4%, and 31.8%, respectively, for overall survival (p<0.001). Decision curve analysis revealed that the use of model was associated with net benefit gains relative to the treat-all strategy. Conclusions: Pretreatment albumin is a simple biomarker based on routinely available well-standardized measures, and is not an expensive and time-consuming process. Hypoalbuminemia is an independent marker of poor prognosis in patients with upper urinary tract urothelial carcinoma.

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Development and External Validation of a New Outcome Prediction Model for Patients With Clear Cell Renal Cell Carcinoma Treated With Nephrectomy Based on Preoperative Serum C-Reactive Protein and TNM Classification: The TNM-C Score

Abstract: In patients with clear cell renal cell carcinoma a new simple scoring model based on serum C-reactive protein and the TNM classification is a useful and easy to use tool for predicting outcome.

Cited by 87 publications

References 19 publications

Prognostic Value of C-Reactive Protein in Esophageal Cancer: a Meta-analysis

Prognostic Value of C-Reactive Protein in Esophageal Cancer: a Meta-analysis

Role of C‐reactive protein in urological cancers: A useful biomarker for predicting outcomes

Preoperative serum albumin as a prognostic factor in patients with upper urinary tract urothelial carcinoma

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