Development and Formulation of Drug-Loaded Hydrogel for Cartilage Regenerative Potential

Abstract

Bone defects resulting from trauma, disease, or congenital abnormalities represent a significant clinical challenge, necessitating advanced regenerative therapies. This study presents the development and formulation of a drug-loaded hydrogel as a novel approach for bone regeneration. The hydrogel matrix is engineered to provide structural support and controlled release of therapeutic agents to enhance bone healing. Various biocompatible polymers and crosslinking strategies are investigated to optimize the hydrogel's mechanical properties, degradation kinetics, and drug release profiles. Furthermore, the study explores the efficacy of different drugs, growth factors, and osteoinductive molecules in promoting osteogenesis and bone tissue regeneration within the hydrogel scaffold. The developed drug-loaded hydrogel holds promise as a versatile platform for addressing diverse bone defects and advancing the field of regenerative orthopedics.