Development and In-vitro characterization of floating drug delivery system of ketoconazole

Abstract

The oral route is increasingly being used for the delivery of therapeutic agents because the low cost of the therapy and ease of administration lead to high level of patient compliances. Floating drug delivery system (FDDS) float in the gastric fluid and prolong GRT to obtain sufficient drug bioavailability, because of their lower bulk density compared to that of the aqueous medium. The aim of the present study is to prepare floating tablets as a delivery system for controlled release of Ketoconazole. Ketoconazole is a drug of choice in antifungal category and gives significant result. Floating tablets containing Ketoconazole were prepared by direct compression technique using varying concentrations of different grades of polymers of Hydrxy Propyl Cellulose & Xanthan gum. To evaluate the prepared floating tablets for various parameters like hardness, friability, uniformity of drug content, in-vitro floating studies, in-vitro dissolution studies.

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“…Gel System: 21,22 1. Diffusion-Controlled Mechanism:  Matrix Devices: The active agent is homogeneously dispersed as a solid into a hydrogel inert bio-degradable polymers matrix as in Fig.…”

Spectrophotometric study of ketoconazole binding with citrate capped silver nanoparticles and its monitoring in human plasma samples

“…However, it has low aqueous solubility (40 μg/mL) in 25 C water, which may leads to, negative impact on the transdermal penetration and poor transdermal transformation. 3 On the other hand, its low water solubility cause difficulty in preparation of pharmaceutical formulations and limits its bioavailability and therapeutic applications. Ketoconazole is consumed in three possible modes such as shampoo, cream and tablet.…”