Development and in vivo evaluation of an innovative “Hydrochlorothiazide-in Cyclodextrins-in Solid Lipid Nanoparticles” formulation with sustained release and enhanced oral bioavailability for potential hypertension treatment in pediatrics

Cirri, Marzia; Mennini, Natascia; Maestrelli, Francesca; Mura, Paola; Ghelardini, Carla; Mannelli, Lorenzo Di Cesare

doi:10.1016/j.ijpharm.2017.02.022

Cited by 63 publications

(72 citation statements)

References 45 publications

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“…A rather similar behavior ( Figure 2C) was observed for the series of products with SBEβCD. As previously observed by Cirri et al, 2017, the thermal profile of this CD showed a broad endothermic effect between 60 to 110 • C due to its dehydration, and another endothermic band between 250 and 280 • C, due to degradation phenomena [30]. All binary systems prepared with the different techniques showed the superimposition of HCT melting and CD decomposition phenomena, similar to that observed in the simple PM.…”

Section: Characterization Of the Drug-cd Binary Systemssupporting

confidence: 84%

Tablets of “Hydrochlorothiazide in Cyclodextrin in Nanoclay”: A New Nanohybrid System with Enhanced Dissolution Properties

et al. 2020

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Hydrochlorothiazide (HCT), a Biopharmaceutical Classification System (BCS) class IV drug, is characterized by low solubility and permeability, that negatively affect its oral bioavailability, reducing its therapeutic efficacy. The combined use of cyclodextrins (CDs) and nanoclays (NCs) recently proved to be a successful strategy in developing delivery systems able to merge the potential benefits of both carriers. In this work, several binary systems of CDs or NCs with the drug were obtained, using different drug:carrier ratios and preparation techniques, and characterized in solution and in solid state, to properly select the most effective system and preparation method. Then, the best CD (RAMEB) and NC (sepiolite), at the best drug:carrier ratio, was selected for preparation of the ternary system by co-evaporation and emerged as the most effective preparation method. The combined presence of RAMEB and sepiolite gave rise to a synergistic improvement of drug dissolution properties, with a two-fold increase in the amount of drug dissolved as compared with the corresponding HCT-RAMEB system, resulting in an approximately 12-fold increase in drug solubility as compared with the drug alone. The ternary system that was co-evaporated was then selected for a tablet formulation. The obtained tablets were fully characterized for technological properties and clearly revealed a better drug dissolution performance than the commercial reference tablet (Esidrex®).

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Section: Characterization Of the Drug-cd Binary Systemssupporting

confidence: 84%

Tablets of “Hydrochlorothiazide in Cyclodextrin in Nanoclay”: A New Nanohybrid System with Enhanced Dissolution Properties

et al. 2020

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“…Drug-loaded lipid nanoparticles could reduce chemical or enzymatic degradation of the drugs which are embedded in a lipid matrix. Lipid nanoparticles could promote lymphatic transport and can bypass the liver and avoid hepatic first pass effect( 50 51 52 130 131 ). Lipid nanoparticles advantages and disadvantages for oral route are listed in Table 3 .…”

Section: Lipid Nanoparticles Applications and Different Routes Of Admmentioning

confidence: 99%

Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages

2018

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During the recent years, more attentions have been focused on lipid base drug delivery system to overcome some limitations of conventional formulations. Among these delivery systems solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are promising delivery systems due to the ease of manufacturing processes, scale up capability, biocompatibility, and also biodegradability of formulation constituents and many other advantages which could be related to specific route of administration or nature of the materials are to be loaded to these delivery systems. The aim of this article is to review the advantages and limitations of these delivery systems based on the route of administration and to emphasis the effectiveness of such formulations.

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“…The test tubes were observed for miscibility. (Marzia Cirri et al, 2017) Formulation of SLNs: Among the various methods available for the preparation of nanoparticles, High-pressure homogenization method has been used for years, and it is a powerful technique for the large scale production. So, this method is used in the preparation of SLNs in the present study.…”

Section: Preparation Of Gcv Loaded Solid Lipid Nanoparticlesmentioning

confidence: 99%

Absorption enhancement effect of piperine and chitosan on ganciclovir sol-id lipid nanoparticles: formulation, optimization and invivo pharmacoki-netics

P²,

Devanna

2019

ijrps

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The purpose of the present study was to formulate Solid Lipid Nanoparticles (SLNs) of Ganciclovir (GCV) in combination with Chitosan and Piperine for absorption enhancement effect. GCV loaded SLNs were prepared by hot homogenization method, optimized and characterized. Formulated SLNs were incorporated with absorption enhancers and characterized for invitro absorption (with chicken intestine), histopathological and invivo pharmacokinetic studies. Invitro absorption studies revealed that the permeability coefficient of the prepared formulation is more when compared to the pure drug, so the permeability is more for prepared formulation. In vivo pharmacokinetic study showed a significant increase in the Cmax, AUC, biological half-life and decrease in elimination rate constant for prepared formulation compared to pure drug. Histopathological studies also showed mild reversible damage of epithelial cells with Chitosan which indicates the safety and efficacy of the formulation. Thus, GCV loaded SLNs prepared with Chitosan can be clinically promising for enhancing the oral, intestinal absorption of the said BCS Class-III drug.

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Development and in vivo evaluation of an innovative “Hydrochlorothiazide-in Cyclodextrins-in Solid Lipid Nanoparticles” formulation with sustained release and enhanced oral bioavailability for potential hypertension treatment in pediatrics

Cited by 63 publications

References 45 publications

Tablets of “Hydrochlorothiazide in Cyclodextrin in Nanoclay”: A New Nanohybrid System with Enhanced Dissolution Properties

Tablets of “Hydrochlorothiazide in Cyclodextrin in Nanoclay”: A New Nanohybrid System with Enhanced Dissolution Properties

Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages

Absorption enhancement effect of piperine and chitosan on ganciclovir sol-id lipid nanoparticles: formulation, optimization and invivo pharmacoki-netics

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