Development and Investigation of Efficient Substrate Feeding and Dissolved Oxygen Control Algorithms for Design of Recombinant E. coli Cultivation Process

Adaptive control of the E. coli-specific growth rate in fed-batch cultivation based on oxygen uptake rate

“…Equations (28) - (30) are differential formulas of the main cultivation process variables [17] , [45] . Equation (34) is the same Monod expression as in Equation (10) , in terms of having its digital twin and observer both depending on the identical object model.…”