Development and large-scale use of recombinant VP2 vaccine for the prevention of infectious bursal disease of chickens

Pitcovski, Jacob; Gutter, Bezalel; Gallili, Gilad E.; Martin, Gottfried; Perelman, B.; Gross, Gideon; Krispel, S; Barbakov, M; Michael, Amnon

doi:10.1016/s0264-410x(03)00525-5

Cited by 97 publications

(43 citation statements)

References 27 publications

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“…The antigenicity of IBDV is dependent on the structural conformation of the major hydrophilic peaks A and B of the VP2 HVR variable region (Schnitzler et al, 1993). In addition, minor hydrophilic peaks 1 and 2 also contributed to IBDV antigenicity (van den Berg et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…The antigenic site responsible for the induction of neutralizing antibodies against IBDV is located on VP2 structural protein (Azad et al, 1987). The genetic basis for the antigenicity and/or virulence of the VP2 protein of IBDV has been studied extensively (Schnitzler et al, 1993;Brandt et al, 2001;van den Berg et al, 2004;Letzel et al, 2007;Durairaj et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…The economic impact of clinical and sub-clinical IBD warrants the search and use of efficient vaccines and vaccination strategies to match changes in the field situation for effective control of IBDV (Whitfill et al, 1995;Pitcovski et al, 2003;Yong-Chang et al, 2005;Lazarus et al, 2008;Le Gros et al, 2009). In Nigeria, most vaccines used for the control of IBDV as well as the virus seed for local vaccine production are imported (Okeke & Tanimu, 1982), leading to frequent vaccination failures in the field (Abdu et al, 2001) due to antigenic differences between local strains and vaccine strains (Owoade et al, 2004;Adamu et al, 2011a).…”

Section: Introductionmentioning

confidence: 99%

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Characterization of field and vaccine infectious bursal disease viruses from Nigeria revealing possible virulence and regional markers in the VP2 minor hydrophilic peaks

et al. 2013

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Outbreaks of infectious bursal disease in vaccinated chicken flocks are frequent in Nigeria. For the control of infectious bursal disease, live vaccines based on foreign infectious bursal disease virus (IBDV) strains are used. The present study investigated the phylogenetic relationship between field and vaccine IBDV strains from northwestern Nigeria. Thirty field IBDV strains and three commercial vaccines strains were characterized through sequencing the VP2 hypervariable region. In addition, the complete genome segment A coding region for two vaccines and two field strains was sequenced. The deduced amino acid sequences (position 212 to 331) of IBDV strains from Nigeria and other regions of the world were aligned and possible regional and virulence markers were identified associated with VP2 minor hydrophilic peaks. Reversion to virulence of a vaccine strain with a Q to L mutation at position 253 was observed. Phylogenetic analyses revealed a unique cluster of northwest Nigerian field IBDV strains alone or related to imported characterized classical and very virulent IBDV vaccines. The results suggest that when IBDV strains spread from their region of origin to a different region they mutate alongside indigenous field strains but may retain their identity on the VP2 region.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characterization of field and vaccine infectious bursal disease viruses from Nigeria revealing possible virulence and regional markers in the VP2 minor hydrophilic peaks

et al. 2013

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“…Infectious bursal disease (IBD), 3 also called Gumboro disease, is an acute, highly contagious disease in young chickens that occurs across the world (1). Its causative agent, IBD virus (IBDV), destroys its target cells, the B lymphocyte precursors (2)(3)(4).…”

Section: Infectious Bursal Disease (Ibd) Is An Acute Highly Contagiomentioning

confidence: 99%

The Association of Receptor of Activated Protein Kinase C 1(RACK1) with Infectious Bursal Disease Virus Viral Protein VP5 and Voltage-dependent Anion Channel 2 (VDAC2) Inhibits Apoptosis and Enhances Viral Replication

Lin

Zhang

et al. 2015

Journal of Biological Chemistry

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Background: IBDV VP5 protein induces apoptosis in DF-1 cells via interaction with VDAC2. Results: RACK1 inhibits IBDV-induced apoptosis, enhances viral replication, and interacts with both VDAC2 and VP5. Conclusion: RACK1 forms a complex with VDAC2 and VP5, affecting IBDV-induced apoptosis and viral replication. Significance: RACK1 inhibits apoptosis via interaction with VDAC2, indicating sequestration of RACK1 and VDAC2 by VP5 during IBDV infection.

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“…Infectious bursal disease (IBD) commonly known as Gumboro disease is a disease of global economic importance (Pitcovski et al, 2003). Cosgrove initially described the disease as -avian nephrosis‖ on account of the tubular degenerative lesions found in the kidneys of infected broiler chickens.…”

Section: Introductionmentioning

confidence: 99%

Immune Response Study to Live Infectious Bursal Disease Vaccines in Broiler Chickens

Kundu¹,

Narang²,

Chhabra³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

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Development and large-scale use of recombinant VP2 vaccine for the prevention of infectious bursal disease of chickens

Cited by 97 publications

References 27 publications

Characterization of field and vaccine infectious bursal disease viruses from Nigeria revealing possible virulence and regional markers in the VP2 minor hydrophilic peaks

Characterization of field and vaccine infectious bursal disease viruses from Nigeria revealing possible virulence and regional markers in the VP2 minor hydrophilic peaks

The Association of Receptor of Activated Protein Kinase C 1(RACK1) with Infectious Bursal Disease Virus Viral Protein VP5 and Voltage-dependent Anion Channel 2 (VDAC2) Inhibits Apoptosis and Enhances Viral Replication

Immune Response Study to Live Infectious Bursal Disease Vaccines in Broiler Chickens

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