2024
DOI: 10.22159/ijap.2024v16i3.50315
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Development and Optimization of a Dolutegravir Nanosuspension Using Box Behnken Design

LAKSHMI DEVI GOTTEMUKKULA,
RAGHUVEER PATHURI

Abstract: Objective: This study aimed to develop and optimize a nanosuspension of Dolutegravir, an integrase inhibitor with low aqueous solubility, using the sonoprecipitation technique. The objective was to enhance the drug's solubility and oral bioavailability by preparing nanosuspension. Methods: A box-behnken design was employed to systematically investigate the impact of stabilizer concentration, sonication amplitude, and time on the particle size and polydispersibility of the nanosuspension formulations. Various s… Show more

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