This work will show an overview of the hydrogen production from ethanol by steam reforming method, using distinct catalysts, resulting in low carbon monoxide content in H2 produced; a thermodynamic analysis of reforming employing entropy maximization, the ideal condition for ethanol, and other steam reforming reactions, the state of the art of steam reforming catalysts for H2 production with low CO content. Moreover, in the second part, there will be an overview of the use of hydrogen in a proton exchange membrane fuel cell (PEMFC), the fuel cell operational conditions, a thermodynamic analysis of PEMFC, the catalysts used in the electrodes of the fuel cell, consequences of the CO presence in the hydrogen fuel feed in PEMFC, and the operation conditions for maximum output power density.