Development and Performance of a Multichannel System for Studies of Biomagnetic Signals of Brain and Heart

Schneider, Siegfried; Abraham-Fuchs, K.; Daalmans, G.; Folberth, W.; Hoenig, H. E.; Reichenberger, Helmut; Röhrlein, G.; Seifert, Hans Jürgen; Wirth, Adrian

doi:10.1007/978-1-4613-0581-1_149

Cited by 11 publications

(3 citation statements)

References 5 publications

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“…One can foresee the combination of these imaging methods with MEG and EEG at several levels. Provided that the coordinate systems for MEG and MRI have been aligned, one can superimpose the locations of brain activity, found by MEG, on the MRI's Schneider et al , 1989;Suk et al , 1989;. It is then possible to compare the locations of source estimates with the actual sites of ana-tomical structures (see Fig.…”

Section: Positron-emission Tomography (Pet) Gives Informationmentioning

confidence: 99%

Magnetoencephalography—theory, instrumentation, and applications to noninvasive studies of the working human brain

et al. 1993

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Magnetoencephalography(MEG) is a noninvasive technique for investigating neuronal activity in the living human brairi. The time resolution of the method is better than 1 ms and the spatial discrimination is, under favorable circumstances, 2 -3 mm for sources in the cerebral cortex. In MEG studies, the weak 10 fT -1 pT magnetic fields produced by electric currents fiowing in neurons are measured with multichannel SQUID {superconducting quantum interference device) gradiometers. The sites in the cerebral cortex that are activated by a stimulus can be found from the detected magnetic-field distribution, provided that appropriate assumptions about the source render the solution of the inverse problem unique. Many interesting properties of the working human brain can be studied, including spontaneous activity and signal processing following external stimuli. For clinical purposes, determination of the locations of epileptic foci is of interest. The authors begiri with a general introduction and a short discussion of the neural basis of MEG. The mathematical theory of the method is then explained in detail, followed by a thorough description of MEG instrumentation, data analysis, and practical construction of multi-SQUID devices. Finally, several MEG experiments performed in the authors laboratory are described, covering studies of evoked responses and of spontaneous activity in both healthy and diseased brains. Many MEG studies by other groups are discussed briefiy as well.

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Section: Positron-emission Tomography (Pet) Gives Informationmentioning

confidence: 99%

Magnetoencephalography—theory, instrumentation, and applications to noninvasive studies of the working human brain

et al. 1993

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“…Therefore current coils, applied to the patient's body, can be used to mark points of interest and to determine their coordinates with the same sensor System that is measuring the biomagnetic activity [1], However, the localization accuracy deteriorates with increasing distance and is crucially dependent upon the orientation of the coil relative to the sensor array.…”

Section: Contour Scan With Coil Probementioning

confidence: 99%

“…Depending on the signal to noise ratio of the data, a localization accuracy of a few millimeters can be achieved [1]. This biomagnetic source localization can then be combined with anatomical imaging like MR or CT, in order to enhance the value for diagnosis and therapy.…”

Section: Introductionmentioning

confidence: 98%

Fusion of Biomagnetlsm with MR or CT Images by Contour-Fitting

Abraham-Fuchs¹,

Lindner²,

Wegener³

et al. 1991

Biomedizinische Technik/Biomedical Engineering

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Magnetoencephalography in clinical epileptology and Epilepsy research

Baumgartner

Deecke

1990

Brain Topogr

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This article reviews the application of magnetoencephalography (MEG) in clinical epileptology and epilepsy research. MEG recordings of interictal as well as ictal epileptiform discharges helped to improve non-invasive localization of epileptic foci in patients with focal epilepsy. Several studies showed good agreement of the localizations obtained from MEG compared with those from invasive electrical recordings. Thus, MEG may become a potentially useful technique in the pre-surgical evaluation of epilepsy patients. As evidenced from studying the penicillin focus in animals and spike propagation in humans, MEG also may contribute to further understand the basic mechanisms of epilepsy and thus may be useful in epilepsy research. Directions of future research include recording from a large number of channels covering a wide area of the head, long-term recording to study mechanisms involved in the transition of interictal to ictal state, and recording of slow magnetic field shifts associated with interictal and ictal epileptiform discharges.

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Development and Performance of a Multichannel System for Studies of Biomagnetic Signals of Brain and Heart

Cited by 11 publications

References 5 publications

Magnetoencephalography—theory, instrumentation, and applications to noninvasive studies of the working human brain

Magnetoencephalography—theory, instrumentation, and applications to noninvasive studies of the working human brain

Fusion of Biomagnetlsm with MR or CT Images by Contour-Fitting

Magnetoencephalography in clinical epileptology and Epilepsy research

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