Development and pharmaceutical performance of a novel co-processed excipient of alginic acid and microcrystalline cellulose

Benabbas, Rihab; Sanchez‐Ballester, Noelia M.; Sharkawi, Tahmer; Soulairol, Ian

doi:10.1016/j.powtec.2020.10.027

Cited by 30 publications

(16 citation statements)

References 27 publications

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“…disintegration mechanism, which combines capillarity and swelling [15,50,51], making it less sensitive to the hydrophobicity of MgSt and comparable to sodium starch glycolate [51]. At 2.5% MgSt, similar and clearer behaviors were observed than for 0.5% MgSt, for all the studied materials.…”

Section: Effect Of Lubrication On Tablet's Disintegrationmentioning

confidence: 83%

“…Cop AA-MCC was obtained by wet granulation of a dry mixture composed of 10% AA (Vivapharm ® Alginate PH 060) and 90% MCC (Vivapur ® 101), as described in previous work [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

“…At Regarding the disintegration time, Cop AA-MCC tablets disintegrated faster than Prosolv ODT tablets, whatever was their composition (pure or formulated). The first one disintegrated by the swelling and the effective water sorption of both AA and MCC [15,50,51]. The second one disintegrated mainly by the wicking and the recovery of elastic energy of crospovidone [53,54].…”

Section: Compaction Studymentioning

confidence: 99%

“…In our previous work, the design, characterization, and optimization of a new co-processed excipient (Cop AA-MCC), based on alginic acid and microcrystalline cellulose, for the preparation of immediate drug release tablets by direct compression was reported. This study demonstrated clearly the effectiveness of the designed co-processed excipient in comparison to the native materials (MCC and AA) and to their physical mixture [ 15 ].…”

Section: Introductionmentioning

confidence: 95%

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Performance Evaluation of a Novel Biosourced Co-Processed Excipient in Direct Compression and Drug Release

et al. 2021

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This study exposes the potential usefulness of a new co-processed excipient, composed of alginic acid and microcrystalline cellulose (Cop AA-MCC), for the preparation of immediate drug release tablets by direct compression. Evaluation of the physical and mechanical properties as well as the disintegration behavior of Cop AA-MCC in comparison to commercial co-processed excipients (Cellactose®, Ludipress®, Prosolv® SMCC HD90 and Prosolv® ODT) and to the physical mixture of the native excipients (MCC and AA), was carried out. The obtained results illustrate the good performance of Cop AA-MCC in terms of powder flowability, tablet tensile strength, compressibility, and disintegration time. Although, this new co-processed excipient showed a slightly high lubricant sensitivity, which was explained by its more plastic than fragmentary deformation behavior, it presented a low lubricant requirement due to the remarkably low ejection force observed during compression. Compression speed and dwell time seemed not to affect significantly the tabletability of Cop AA-MCC. The study exposed evenly the performance of Cop AA-MCC compared to Prosolv® ODT, in terms of tabletability and dissolution rate of Melatonin. Cop AA-MCC presented comparable hardness, lower dilution potential, higher lubricant sensitivity, lower ejection force, and faster Melatonin’s release time than Prosolv® ODT. In summary, Cop AA-MCC exhibited interesting physical, mechanical, and biopharmaceutical properties, which demonstrate its concurrence to commercially available co-processed excipients. Furthermore, the simplicity of its composition and the scalability of its elaboration makes this multifunctional excipient highly recommended for direct compression.

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Section: Effect Of Lubrication On Tablet's Disintegrationmentioning

confidence: 83%

“…Cop AA-MCC was obtained by wet granulation of a dry mixture composed of 10% AA (Vivapharm ® Alginate PH 060) and 90% MCC (Vivapur ® 101), as described in previous work [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Compaction Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

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Performance Evaluation of a Novel Biosourced Co-Processed Excipient in Direct Compression and Drug Release

et al. 2021

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“…moisture that the cellulose is able to absorb. The higher the degree of crystallinity, the less hydroxyl groups available for the attachment of water molecules, and therefore the cellulose has a lower ability to water or absorb moisture [41]. For PEG-containing hydrogels, a network is formed whose mesh size is affected by the chain length of the PEG used.…”

Section: Swellingmentioning

confidence: 99%

Plasma-Activated Polyvinyl Alcohol Foils for Cell Growth

et al. 2020

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Hydrogels, and not only natural polysaccharide hydrogels, are substances capable of absorbing large amounts of water and physiological fluids. In this study, we set out to optimize the process for preparing polyvinyl alcohol (PVA) hydrogels. Subsequently, we doped PVA foils with cellulose powder, with poly(ethylene glycol) (PEG) or with gold nanoparticles in PEG colloid solutions (Au). The foils were then modified in a plasma discharge to improve their biocompatibility. The properties of PVA foils were studied by various analytical methods. The use of a suitable dopant can significantly affect the surface wettability, the roughness, the morphology and the mechanical properties of the material. Plasma treatment of PVA leads to ultraviolet light-induced crosslinking and decreasing water absorption. At the same time, this treatment significantly improves the cytocompatibility of the polymer, which is manifested by enhanced growth of human adipose-derived stem cells. This positive effect on the cell behavior was most pronounced on PVA foils doped with PEG or with Au. This modification of PVA therefore seems to be most suitable for the use of this polymer as a cell carrier for tissue engineering, wound healing and other regenerative applications.

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Chemical, physical and biological methods to convert lignocellulosic waste into value-added products. A review

Viswanathan²,

et al. 2022

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Development and pharmaceutical performance of a novel co-processed excipient of alginic acid and microcrystalline cellulose

Cited by 30 publications

References 27 publications

Performance Evaluation of a Novel Biosourced Co-Processed Excipient in Direct Compression and Drug Release

Performance Evaluation of a Novel Biosourced Co-Processed Excipient in Direct Compression and Drug Release

Plasma-Activated Polyvinyl Alcohol Foils for Cell Growth

Chemical, physical and biological methods to convert lignocellulosic waste into value-added products. A review

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