Development and qualitative evaluation of periodontal gel containing an antibacterial agent for periodontal disease

Abstract

The present study aims at the development and evaluation of dental gel containing metronidazole non-biodegradable polymers for targeted delivery of drug and thus prolonging the action. Hot Method was used for the preparation of gel. Natural polymers like, Guar gum, Sodium alginate, Chitosan, Xanthan gum, Gellan gum were used in the formulations of gel. Prepared gels were evaluated for pH, rheological study, spreadability study, gelation, and gel melting study. At last Field Emission Scanning Electron Microscopy FESEM, Differential Scanning Calorimetry (DSC), Thermo Gravimetric Analysis (TGA), Texture Profile Analysis (TPA) have been done on an optimized gel formulation. All gels revealed pH ranged between 6.16 to 6.47, spreadability between 28.37 to 45.03 g.cm/sec, drug content between 90.01 to 99.10 % viscosity ranged between 3108.44 cps and 3645.47 cps and formulations F3 and F10 showed gelation temperature 39±0.12OC and 37±0.13OC respectively which is similar to the temperature of the body. Surface of the sample gels showed no drug particles, indicating a homogeneous mixture of polymers of drugs as well as natural agents. Formulation F10 containing Guar gum showed slower degradation in all media as compared to gels made of Sodium alginate, Xanthan gum, Chitosan, Gellan gum. DSC results revealed that the drug has the same state in the optimized formulation. TGA results showed that the formulation was found to have high stability in high-temperature settings. TPA results of optimized F10 revealed the parameters Mucoadhesive strength 92.54 ± 2.65 g, Hardness 25.34 ± 0.01N/mm², Compressibility 57.75 ± 0.40N mm, Adhesiveness−4.56 ± 0.26 N mm, Cohesiveness 0.83 ± 0.06. Hence, it is concluded that Metronidazole gel with gellan gum showed a longer degradation time and guar gum showed slower degradation in all over polymers used in gel formulations.

Effectiveness of chlorhexidine gels and chips in Periodontitis Patients after Scaling and Root Planing: a systematic review and Meta-analysis

“…The first study by Goodson et al which demonstrated in vitro drug release for up to nine days [ 25 ]. Metronidazole is a broad-spectrum antibiotic and is active against most periodontal pathogens [ 26 ]. Minocycline is one of the most active antibiotics against most of the microorganisms associated with periodontal disease [ 27 ].…”

Cold Emulsified Nanoemulsion: Enhancing Delivery and Stability of Thermolabile Acyclovir

“…13,14 A comparative diffusion profile study between nanoemulsion and conventional macroemulsion has shown steady-state flux and better skin penetration of nanoemulsion than the surfactant-based emulsion system. 15 Optimized acyclovir nanoemulsion has also shown significantly better diffusion compared to conventional hot emulsification process based marketed formulation. All the results signify that the cold emulsification process is Each value is a mean of three determinations ± SD (n = 3).…”

Preparation and Evaluation of Polyherbal Periodontal Gel for Treatment of Periodontitis

“…The specific makeup of these infections varies from person to person and, to some extent, from site to site on various teeth of the same topic. 2 Presently, more than 300 species of microbes have been identified in the oral cavity; however, only 5% of these are thought to be strongly linked to periodontitis, with 1% being present in more than 90% of occasions (Slots, personal interaction). Sadly, the identification of the disease's causative agents in humans has been hampered by the complexities of the flora, the sporadic nature of disease action episodes, and the comparatively wide variations in the data collected within and between subjects.…”

“…Polyherbal gel represents a different strategy in the therapeutic and preventive management of oral and periodontal infections. 4 It has a wide range of therapeutic potencies, such as anti-inflammatory, antimicrobial, and antioxidant effects. Represent a different strategy for treating and preventing oral and periodontal infections.…”