Development and validation of a model for the prediction of disease-specific survival in patients with oral squamous cell carcinoma: based on random survival forest analysis

Wang, Na; Lin, Yulan; Song, Haoyuan; Huang, Wei; Huang, Jinke; Shen, Liling; Chen, Fa; Liu, Fengqiong; Wang, Jing; Qiu, Yu; Shi, Bin; Lin, Lisong; He, Baochang

doi:10.1007/s00405-023-08087-6

Cited by 1 publication

(1 citation statement)

References 35 publications

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“…If the disease is caught early, resection can lead to good cosmetic and survival outcomes. Although it has been suggested that OSCC follows a progression from atypia to dysplasia to full invasive malignancy, most cases of the disease are discovered when it is already in an advanced stage [ 8 ]. Surgery in these cases often leads to significant disfigurement and comorbidities such as issues with eating and swallowing.…”

Section: Introductionmentioning

confidence: 99%

Overcoming Resistance to Standard-of-Care Therapies for Head and Neck Squamous Cell Carcinomas

Gauss,

Stone,

Ghafouri

et al. 2024

Cells

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Although there have been some advances during in recent decades, the treatment of head and neck squamous cell carcinoma (HNSCC) remains challenging. Resistance is a major issue for various treatments that are used, including both the conventional standards of care (radiotherapy and platinum-based chemotherapy) and the newer EGFR and checkpoint inhibitors. In fact, all the non-surgical treatments currently used for HNSCC are associated with intrinsic and/or acquired resistance. Herein, we explore the cellular mechanisms of resistance reported in HNSCC, including those related to epigenetic factors, DNA repair defects, and several signaling pathways. This article discusses these mechanisms and possible approaches that can be used to target different pathways to sensitize HNSCC to the existing treatments, obtain better responses to new agents, and ultimately improve the patient outcomes.

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Section: Introductionmentioning

confidence: 99%