Development and validation of a liquid chromatography tandem mass spectrometry multi-method for the determination of 41 free and modified mycotoxins in beer

Rausch, Ann-Kristin; Brockmeyer, Robert; Schwerdtle, Tanja

doi:10.1016/j.foodchem.2020.127801

Cited by 35 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…zearalenone-14-glucoside (ZEN-14G), zearalenone-14-sulfate (ZEN-14S), zearalenone-14,16disulfate (ZENdiS), α-zearalenol-14-glucoside (α-ZEL-14G), α-zearalenol-14-sulfate (α-ZEL-14S), β-zearalenol-14-glucoside (β-ZEL-14G), β-zearalenol-14-sulfate (β-ZEL-14S), and zearalanone-14-glucoside (ZAN-14G) can be purchased from ASCA GmbH (Berlin, Germany). These eight conjugates were incorporated into the multianalyte method for determination of mycotoxins and their metabolites in beer (Rausch et al, 2021).…”

Section: Quality Control Of Mycotoxin Analysesmentioning

confidence: 99%

“…https://www.wageningenacademic.com/doi/pdf/10.3920/WMJ2021. 2752-Sunday, March 06, 2022 Although beer has been often targeted for mycotoxin analysis, the method proposed by Rausch et al (2021) provided a very comprehensive overview of potentially occurring parent and modified forms. Beer being a complex matrix, the extraction and clean up procedures reported in the literature are commonly SPE, immunoaffinity, or QuEChERS based.…”

Section: Chromatography With Ms/msmentioning

confidence: 99%

See 1 more Smart Citation

Developments in mycotoxin analysis: an update for 2020-2021

Tittlemier¹,

Cramer

Dall’Asta

et al. 2022

WMJ

View full text Add to dashboard Cite

This review summarises developments published in the period from mid-2020 to mid-2021 on the analysis of a number of diverse matrices for mycotoxins. Notable developments in all aspects of mycotoxin analysis, from sampling and quality assurance/quality control of analytical results, to the various detection and quantitation technologies ranging from single mycotoxin biosensors to comprehensive instrumental methods are presented and discussed. The summary and discussion of this past year’s developments in detection and quantitation technology covers chromatography with targeted or non-targeted high resolution mass spectrometry, tandem mass spectrometry, detection other than mass spectrometry, biosensors, as well as assays using alternatives to antibodies. This critical review aims to briefly present the most important recent developments and trends in mycotoxin determination, as well as to address limitations of the presented methodologies.

show abstract

Section: Quality Control Of Mycotoxin Analysesmentioning

confidence: 99%

Section: Chromatography With Ms/msmentioning

confidence: 99%

Developments in mycotoxin analysis: an update for 2020-2021

Tittlemier¹,

Cramer

Dall’Asta

et al. 2022

WMJ

View full text Add to dashboard Cite

show abstract

“…Mycotoxin reference standards were supplied by Sigma-Aldrich (Steinheim, Germany), LGC Standards (Wesel, Germany), HPC Standards (Cunnersdorf, Germany), ASCA (Berlin, Germany), Cfm Oskar Tropitzsch (Marktredwitz, Germany), WITEGA Laboratorien Berlin-Adlershof (Berlin, Germany), Toronto Research Chemicals (Toronto, ON, Canada), and Romer Labs Diagnostic (Tulln, Austria). Hydrolyzed fumonisin standards were prepared as described previously in Rausch et al (2020) [32]. Plant growth regulators and tropane alkaloids were purchased from LGC Standards (Wesel, Germany) and Honeywell (Seelze, Germany).…”

Section: Standardsmentioning

confidence: 99%

Development, validation, and application of a multi-method for the determination of mycotoxins, plant growth regulators, tropane alkaloids, and pesticides in cereals by two-dimensional liquid chromatography tandem mass spectrometry

2021

Self Cite

View full text Add to dashboard Cite

Mycotoxins and pesticides regularly co-occur in agricultural products worldwide. Thus, humans can be exposed to both toxic contaminants and pesticides simultaneously, and multi-methods assessing the occurrence of various food contaminants and residues in a single method are necessary. A two-dimensional high performance liquid chromatography tandem mass spectrometry method for the analysis of 40 (modified) mycotoxins, two plant growth regulators, two tropane alkaloids, and 334 pesticides in cereals was developed. After an acetonitrile/water/formic acid (79:20:1, v/v/v) multi-analyte extraction procedure, extracts were injected into the two-dimensional setup, and an online clean-up was performed. The method was validated according to Commission Decision (EC) no. 657/2002 and document N° SANTE/12682/2019. Good linearity (R2 > 0.96), recovery data between 70-120%, repeatability and reproducibility values < 20%, and expanded measurement uncertainties < 50% were obtained for a wide range of analytes, including very polar substances like deoxynivalenol-3-glucoside and methamidophos. However, results for fumonisins, zearalenone-14,16-disulfate, acid-labile pesticides, and carbamates were unsatisfying. Limits of quantification meeting maximum (residue) limits were achieved for most analytes. Matrix effects varied highly (−85 to +1574%) and were mainly observed for analytes eluting in the first dimension and early-eluting analytes in the second dimension. The application of the method demonstrated the co-occurrence of different types of cereals with 28 toxins and pesticides. Overall, 86% of the samples showed positive findings with at least one mycotoxin, plant growth regulator, or pesticide. Graphical abstract

show abstract

“…A partir do conhecimento de cada etapa de operação e tendo em vista à importância econômica desse segmento no mercado, é de interesse reduzir as perdas econômicas estando entre estas à contaminação por micotoxinas ocorrente tanto nos cereais malteados (CASTAÑARES et al, 2020;LANCOVA, et al 2008;PIACENTINI et al 2019) utilizados no processo cervejeiro, como também na bebida (ADEKOYA et al, 2018;CAMPONE et al, 2020;RAUSCH;BROCKMEYER;SCHWERDTLE, 2021).…”

Section: Processo Cervejeirounclassified

Desenvolvimento De Barras Alimentícias Utilizando Misturas De Frutas Desidratadas

Chauca¹,

Rodrigues²,

Freitas³

et al. 2021

Ensino E Pesquisa No Campo Da Engenharia E Da Tecnologia De Alimentos 2

View full text Add to dashboard Cite

Direitos para esta edição cedidos à Atena Editora pelos autores. Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

show abstract

Development and validation of a liquid chromatography tandem mass spectrometry multi-method for the determination of 41 free and modified mycotoxins in beer

Cited by 35 publications

References 28 publications

Developments in mycotoxin analysis: an update for 2020-2021

Developments in mycotoxin analysis: an update for 2020-2021

Development, validation, and application of a multi-method for the determination of mycotoxins, plant growth regulators, tropane alkaloids, and pesticides in cereals by two-dimensional liquid chromatography tandem mass spectrometry

Desenvolvimento De Barras Alimentícias Utilizando Misturas De Frutas Desidratadas

Contact Info

Product

Resources

About