Development and Validation of a High- Throughput Method for the Determination of Titanium Dioxide in Rodent Lung and Lung-Associated Lymph Node Tissues

Ultrafine titanium dioxide nanoparticles induce cell death in human bronchial epithelial cells

“…Traditionally, TiO 2 has been commonly accepted as a biologically inert substance to both animals and humans [3][4][5][6][7]. As a consequence, it is utilised widely in commercial products such as paints, cosmetics, textiles, papers, plastics, sunscreens and food [8][9][10]. Titanium dioxide nanoparticles (TNPs) are added to many commercial products; however, little is known about the environmental and health implications of their use.…”

Functionalized Positive Nanoparticles Reduce Mucin Swelling and Dispersion

“…A myriad of functionalized-NPs have been used to develop commercial commodities in various industrial sectors. They are heavily implemented in the manufacturing of paint, carpet, paper, plastic, textiles, clothes and cosmetics [1] , [2] , [3] , [4] . NPs also play major roles in decontaminating aqueous wastes and food processing [4] , [5] , [6] .…”

Modeling human health characterization factors for indoor nanomaterial emissions in life cycle assessment: a case-study of titanium dioxide

“…41,62,63 Dose-response data reported for dry lung samples were converted to wet lung with the conversion factor of 0.11 based on previous results showing that nearly 89% of the lung-weight is lost after drying. 64 Interspecies extrapolation factors account for the difference in physiology, such as breathing and body weight, between species, however a factor of one was applied in this study, under the assumption that effects based on internal doses were equivalent in animals and humans. 62 Furthermore, the ED 50a,t,int assumed a 1 : 1 correlation of inflammation, reported as extra risk, and disease probability.…”