2021
DOI: 10.3389/fonc.2021.603031
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Development and Validation of a Prognostic Nomogram for Gastric Signet Ring Cell Carcinoma: A Multicenter Population-Based Study

Abstract: BackgroundGastric signet ring cell carcinoma (GSRCC) is a rare disease associated with poor prognosis. A prognostic nomogram was developed and validated in this study to assess GSRCC patients’ overall survival (OS).MethodsPatients diagnosed with GSRCC from the Surveillance, Epidemiology, and End Results (SEER) database (2004–2016) and the First Hospital of China Medical University (CMU1h) were enrolled in this retrospective cohort study. Univariate and multivariate COX analysis was used to determine independen… Show more

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Cited by 11 publications
(12 citation statements)
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“…However, there are also studies reporting that histological grade is not a prognostic factor in signet-ring cell gastric carcinomas. 18 In our study, we observed that high histological grade, depth of infiltration, and lymph node metastasis adversely affected the mean survival.…”
Section: Discussionmentioning
confidence: 61%
“…However, there are also studies reporting that histological grade is not a prognostic factor in signet-ring cell gastric carcinomas. 18 In our study, we observed that high histological grade, depth of infiltration, and lymph node metastasis adversely affected the mean survival.…”
Section: Discussionmentioning
confidence: 61%
“…The studies carried out by Wang et al, Zhang et al, and Guo et al also had similar problems [ 13 , 14 , 28 ]. Wei et al collected 1,030 patients from the SEER database and constructed CSS prognostic model.…”
Section: Discussionmentioning
confidence: 88%
“…Accurate prediction is essential for the survival of patients with nonmetastatic GSRC and medical decisionmaking. Previous regression analysis-based models have been developed to predict the survival of patients with non-metastatic GSRC [13][14][15]. Nonetheless, these models are commonly based on the assumption that each parameter, and the survival outcomes of GSRC were linear dependent (regression model).…”
Section: Introductionmentioning
confidence: 99%
“…From the current researches on SRCC, it is known that a variety of prognostic factors can affect the survival rate of SRCC patients: age, tumor size, tumor stage, radiotherapy, chemotherapy, and surgical resection [ 9 , 10 ]. Among these factors, surgical resection is the most effective treatment for SRCC patients [ 8 ].…”
Section: Discussionmentioning
confidence: 99%