Development and validation of a nomogram for predicting Mycoplasma pneumoniae pneumonia in adults

Abstract

The study aimed to explore predictors of Mycoplasma pneumoniae pneumonia (MPP) in adults and develop a nomogram predictive model in order to identify high-risk patients early. We retrospectively analysed the clinical data of a total of 337 adult patients with community-acquired pneumonia (CAP) and divided them into MPP and non-MPP groups according to whether they were infected with MP. Univariate and multivariate logistic regression analyses were used to screen independent predictors of MPP in adults and to developed a nomogram model. Receiver operating characteristic (ROC) curve, calibration curve, concordance index (C-index), and decision curve analysis (DCA) were used for the validation of the evaluation model. Finally, the nomogram was further evaluated by internal verification. Age, body temperature, dry cough, dizziness, CRP and tree-in-bud sign were independent predictors of MPP in adults (P < 0.05). The nomogram showed high accuracy with C-index of 0.836 and well-fitted calibration curves in both the training and validation sets. The area under the receiver operating curve (AUROC) was 0.829 (95% CI 0.774–0.883) for the training set and 0.847 (95% CI 0.768–0.925) for the validation set. This nomogram prediction model can accurately predict the risk of MPP occurrence in adults, which helps clinicians identify high-risk patients at an early stage and make drug selection and clinical decisions.

Comparison of the clinical characteristics in parents and their children in a series of family clustered Mycoplasma pneumoniae infections

“…The radiological findings showed that the most common manifestation was patchy opacities, followed by bronchial wall thickening (more common in children). These findings are non-specific and similar to those reported in previous studies on MP [ 5 , 12 ]. Several researchers have proposed that the bronchial wall thickening could serve as a diagnostic indicator [ 15 ].…”

“…The caregivers had an average age of 35.1 ± 4.6 years, and most of them were female. A plausible explanation is the differences in immunity and social activities between men and women, and the fact that mother in Chinese families tend to care for children more and have closer contact with them [ 6 , 12 ]. Both groups had similar clinical symptoms, with fever and cough being the most frequent on admission.…”

Detection of Mycoplasma Pneumoniae Using Targeted Next-Generation Sequencing: A Comparative Analysis of Clinical Characteristics in Pure Infections and Co-Infections

“…Although most studies have focused on children with Mycoplasma pneumoniae infection, the incidence of Mycoplasma pneumoniae infection in adults with community-acquired pneumonia has increased in recent years [14][15][16] . In this study, we used tNGS technology to analyze bronchoalveolar lavage uid samples to explore the differences in co-infection and pathogen spectrum between pediatric and adult patients.…”

Community-acquired pneumonia: antibiotic therapy approach after the COVID-19 pandemic. A review

“…С этой целью применимы такие доступные маркеры, как прокальцитонин и отношение СРБ/прокальцитонин >350 мкг/нг [42]. Последний показатель, по ограниченным данным, может свидетельствовать о микоплазменной пневмонии, тем более если при мультиспиральной компьютерной томографии выявлен феномен «дерево в почках» [43,44].…”