Development and Validation of A RP- HPLC Method for the Simultaneous Estimation of Valsartan and Sacubitril in Rat Plasma

Abstract

Foeniculum vulgare (Apiaceae / Umbelliferae) commonly known as fennel is a well-known and important medicinal and aromatic plant widely used as digestive, diuretic, Asthma, Brest feeding women, Diabetes help lower cholesterol level, cure edema, Anxiety, Depression, gastrointestinal disorders. Its seeds are used as Blood pressure, reduce asthma symptoms, reduce water Retention, Helps purify Blood, Improves eyesight. In vitro and in vivo models, many pharmacological experiments have demonstrated the ability to perform strongly Foeniculum vulgare to exhibit antifungal, antibacterial, antioxidant, anti-anxiety, and anti depression activities, supporting the argument behind its many therapeutic uses. Phenolic compounds separated by Foeniculum vulgare are considered responsible for antioxidant activity, while unstable aroma compounds make it an excellent flavour agent. The current review is an up-to-date and comprehensive analysis of the safety of chemistry, pharmacology, convention use and Foeniculum vulgare.