Development and Validation of a Rapid and Simple HPLC-Uv Method for the Analysis of Sorafenib in the Presence of Polyamidoamine (Pamam) Dendrimers

Hashemi, Fateme; Tamaddon, Ali Mohammad; Yousefi, Gholamhossein; Farvadi, Fakhrossadat

doi:10.1080/10826076.2013.794737

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…The accuracy [Bias (%)] and precision [RSD (%)] values, calculated from three different sets of quality control samples analyzed in triplicate on four different days, ranged from −3.6-16 and 2.1-14.5, respectively. The limit of quantitation was 97 ng/mL 6 .…”

Section: Hplc Methodsmentioning

confidence: 99%

Analytical estimation methods for determination of sorafenib

Thangabalan¹,

Kuruba²,

Goswami³

et al. 2022

World J. Bio. Pharm. Health Sci.

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Sorafenib is an anticancer drug is used to treat late stage kidney and liver cancer. Sorafenib is used to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the kidneys). Sorafenib is also used to treat hepatocellular carcinoma (a type of liver cancer) that cannot be treated with surgery and a certain type of thyroid cancer that has spread to other parts of the body and cannot be treated with radioactive iodine. Sorafenib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells. There are many reported analytical methods for estimation of Sorafenib. The present work list outs the various analytical methods for the estimation of the drug.

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Section: Hplc Methodsmentioning

confidence: 99%

Analytical estimation methods for determination of sorafenib

Thangabalan¹,

Kuruba²,

Goswami³

et al. 2022

World J. Bio. Pharm. Health Sci.

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“…According to our previous report 41 with little modification, a chromatographic method was developed for SFB assay using Knauer HPLC system, equipped with P1000 LPG pump and multiple wavelengths UV P2600 detector. Separation of SFB was achieved using a reversed phase column (C18, 1250-4.6mm, Merck, Germany) at room temperature.…”

Section: Methodsmentioning

confidence: 99%

Effect of PEGylation on assembly morphology and cellular uptake of poly ethyleneimine-cholesterol conjugates for delivery of sorafenib tosylate in hepatocellular carcinoma

et al. 2018

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Introduction: Sorafenib (SFB) is an FDA-approved chemotherapeutic agent with a high partition coefficient (log P = 4.34) for monotherapy of hepatocellular carcinoma (HCC). The oral bioavailability is low and variable, so it was aimed to study the application of the polymeric nanoassembly of cholesterol conjugates of branched polyethyleneimine (PEI) for micellar solubilization of SFB and to investigate the impact of the polymer PEGylation on the physicochemical and cellular characteristics of the lipopolymeric dispersions. Methods: Successful synthesis of cholesterol-PEI lipopolymers, either native or PEGylated, was confirmed by FTIR, 1H-NMR, pyrene assay methods. The nanoassemblies were also characterized in terms of morphology, particle size distribution and zeta-potential by TEM and dynamic light scattering (DLS). The SFB loading was optimized using general factorial design. Finally, the effect of particle characteristics on cellular uptake and specific cytotoxicity was investigated by flow cytometry and MTT assay in HepG2 cells. Results: Transmission electron microscopy (TEM) showed that PEGylation of the lipopolymers reduces the size and changes the morphology of the nanoassembly from rod-like to spherical shape. However, PEGylation of the lipopolymer increased critical micelle concentration (CMC) and reduced the drug loading. Moreover, the particle shape changes from large rods to small spheres promoted the cellular uptake and SFB-related cytotoxicity. Conclusion: The combinatory effects of enhanced cellular uptake and reduced general cytotoxicity can present PEGylated PEI-cholesterol conjugates as a potential carrier for delivery of poorly soluble chemotherapeutic agents such as SFB in HCC that certainly requires further investigations in vitro and in vivo.

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“…Solubilising hydrophobic drug molecules is of great importance in the clinical settings specifically with anticancer substances since most of chemotherapeutics are highly hydrophobic such as DTX, paclitaxel, sorafenib and etoposide. Hence, nanocarriers may bring forth a great potential to enhance the solubility of such drugs [206–209] …”

Section: Multimodal Sbnps Based Nanosystemsmentioning

confidence: 99%

Silica‐Based Nanoparticles as Drug Delivery Vehicles for Prostate Cancer Treatment

Tiburcius

Krishnan

Yang

et al. 2020

The Chemical Record

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Prostate cancer (PCa) is one of the most commonly diagnosed cancers and is the fifth common cause of cancer‐related mortality in men. Current methods for PCa treatment are insufficient owing to the challenges related to the non‐specificity, instability and side effects caused by the drugs and therapy agents. These drawbacks can be mitigated by the design of a suitable drug delivery system that can ensure targeted delivery and minimise side effects. Silica based nanoparticles (SBNPs) have emerged as one of the most versatile materials for drug delivery due to their tunable porosities, high surface area and tremendous capacity to load various sizes and chemistry of drugs. This review gives a brief overview of the diagnosis and current treatment strategies for PCa outlining their existing challenges. It critically analyzes the design, development and application of pure, modified and hybrid SBNPs based drug delivery systems in the treatment of PCa, their advantages and limitations.

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Development and Validation of a Rapid and Simple HPLC-Uv Method for the Analysis of Sorafenib in the Presence of Polyamidoamine (Pamam) Dendrimers

Cited by 6 publications

References 14 publications

Analytical estimation methods for determination of sorafenib

Analytical estimation methods for determination of sorafenib

Effect of PEGylation on assembly morphology and cellular uptake of poly ethyleneimine-cholesterol conjugates for delivery of sorafenib tosylate in hepatocellular carcinoma

Silica‐Based Nanoparticles as Drug Delivery Vehicles for Prostate Cancer Treatment

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