Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Estimation of Rivaroxaban in Human Plasma

Pathan, Mudassarahemadkhan; Kshirsagar, Ajay D.

doi:10.1080/22297928.2020.1871069

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“…10 Pathan et al established development and validation by LC-MS method on RVB for human plasma. 11 Oliveira et al worked on LC-MS/MS instrument and developed sensitive method in plasma for quantification of RVB. 12 Alam et al established ecofriendly HPTLC method using green solvents in nanoparticle formulations for RVB estimation.…”

Section: Introductionmentioning

confidence: 99%

Validated Stability Indicating HPTLC Method Development for Rivaroxaban in Tablets

Nimje,

Magar,

Kamble

et al. 2024

Ind. J. Pharm. Edu. Res

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Section: Introductionmentioning

confidence: 99%

Validated Stability Indicating HPTLC Method Development for Rivaroxaban in Tablets

Nimje,

Magar,

Kamble

et al. 2024

Ind. J. Pharm. Edu. Res

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An Eco-Friendly Ultra-Performance Liquid Chromatography–Mass Spectrometry Method for Quantification of Rivaroxaban and Ticagrelor in Rat Plasma: Grapefruit Interactions

Moffid,

Mostafa,

Mahmoud

et al. 2023

Bioanalysis

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Aim: An eco-friendly ultra-performance liquid chromatography–tandem mass spectrometry method was developed to study the pharmacokinetics of rivaroxaban and ticagrelor in rat plasma, utilizing moxifloxacin as an internal standard. The food–drug interaction between grapefruit juice and these drugs was also investigated. Methods: Liquid–liquid extraction was used. A nonporous stationary phase Agilent® Poroshell 120EC C18 column was used with methanol: 0.1% aqueous formic acid (95:5 v/v) as a mobile phase. The detection was performed in multiple reaction monitoring mode using positive electrospray ionization. The method’s validation was conducted in accordance with US FDA and European Medicines Agency guidelines. Results & conclusion: Grapefruit juice should be ingested with caution in patients treated with antithrombotic medications as it may increase their plasma concentration, inducing bleeding, and requires close clinical monitoring.

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Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Estimation of Rivaroxaban in Human Plasma

Cited by 2 publications

References 17 publications

Validated Stability Indicating HPTLC Method Development for Rivaroxaban in Tablets

Validated Stability Indicating HPTLC Method Development for Rivaroxaban in Tablets

An Eco-Friendly Ultra-Performance Liquid Chromatography–Mass Spectrometry Method for Quantification of Rivaroxaban and Ticagrelor in Rat Plasma: Grapefruit Interactions

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