“…Several LC-MS/MS method have been reported for the estimation of sitagliptin in biological matrices, such as plasma, urine and hemodialysate. The majority of the reported methods are used in clinical applications (Zeng et al, , 2010Nirogi et al, 2008;Hess et al, 2011;Bonde et al, 2013;Burugula et al, 2013;Reddy et al, 2015;Scherf-Clavel and Högger, 2015) compared with preclinical applications (Yao et al, 2011;Gananadhamu et al, 2012;Patel et al, 2014). Shantikumar et al (2015) reported an LC-QTOF/MS method for the determination of five gliptins (vildagliptin, saxagliptins, sitagliptins, linagliptins and teneligliptin) in clinical application.…”