2021
DOI: 10.3389/fonc.2021.736573
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Development and Validation of a Clinical Prognostic Nomogram for Esophageal Adenocarcinoma Patients

Abstract: BackgroundClinical staging is essential for clinical decisions but remains imprecise. We purposed to construct a novel survival prediction model for improving clinical staging system (cTNM) for patients with esophageal adenocarcioma (EAC).MethodsA total of 4180 patients diagnosed with EAC were extracted from the Surveillance, Epidemiology, and End Results (SEER) database and included as the training cohort. Significant prognostic variables were identified for nomogram model development using multivariable Cox … Show more

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Cited by 12 publications
(15 citation statements)
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“…In recent years, the nomogram has been widely used as a predictive method in oncology, which has been shown to present better predictive power than traditional TNM classification. 11 13 In our previous study, the nomogram model also exhibited favorable discriminative ability for stage I-III LUSC. 14 …”
Section: Introductionmentioning
confidence: 77%
“…In recent years, the nomogram has been widely used as a predictive method in oncology, which has been shown to present better predictive power than traditional TNM classification. 11 13 In our previous study, the nomogram model also exhibited favorable discriminative ability for stage I-III LUSC. 14 …”
Section: Introductionmentioning
confidence: 77%
“…In relation to tumor characteristics, the prognosis of elderly patients with POSNs was significantly correlated with the tumor extent, the condition of distant metastasis, and the degree of tumor differentiation. Higher T stage had been previously identified as a predictor of poor prognosis for several malignancies [ 19 21 ]. The T stage of the current AJCC TNM staging system for the case of malignant bone tumor occurring in the osseous spine is based on the extent of tumor invasion.…”
Section: Discussionmentioning
confidence: 99%
“…A series of nomograms have been reported to predict the survival of patients with EC ( 6 9 ). Shao et al.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, survival rates in stage-matched cohorts varies widely (5). To improve the precision of EC survival estimations, nomograms have gained popularity as a method for predicting outcomes (6)(7)(8)(9). A nomogram is a Cox proportional hazard (CPH) model designed to allow straightforward graphical calculation of the probability of a specific outcome, such as esophageal cancer-specific survival (ECSS).…”
Section: Introductionmentioning
confidence: 99%