Development and validation of a liquid chromatography–electrosprayionization mass spectrometric method for the determination of dexamethasone in sheep plasma

Panderi, Irene; Gerakis, Athanasios M.; Zonaras, Vassilios; Athanasiou, Labrini V.; Kazanis, Michael

doi:10.1016/j.aca.2003.10.041

Cited by 13 publications

(7 citation statements)

References 17 publications

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“…It is also used to induce precocious fetal lung maturation in threatened preterm labor [1][2][3]. Dexamethasone is available as the free alcohol and in the form of a variety of C-21 ester prodrugs which are either water-soluble for intravenous (I.V.)…”

Section: Introductionmentioning

confidence: 99%

“…Numerous chromatographic methods have been reported for the determination of dexamethasone in biological matrices based on high-performance liquid chromatography (HPLC) with detection by ultraviolet spectroscopy [7], mass spectrometry (MS) [2,8,9] and tandem mass spectrometry (MS/MS) [3,[10][11][12]. Gas chromatography/mass spectrometry (GC/MS) has also been used but mainly for the analysis of residues in tissues of meat-producing animals [7,13].…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous quantitation of dexamethasone palmitate and dexamethasone in human plasma by liquid chromatography/tandem mass spectrometry

Yang

Gao

et al. 2008

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Simultaneous quantitation of dexamethasone palmitate and dexamethasone in human plasma by liquid chromatography/tandem mass spectrometry

Yang

Gao

et al. 2008

Journal of Chromatography B

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“…Despite the extensive use of antibiotics in animals, reliable data about the pattern of use and the quantity of these compounds are not always available [ 22 ]. That is why it is important to monitor the concentration levels of antibiotic residues in animals and in food products of animal origin [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. Studies on the quantitative risk assessment of foods provide important frameworks to address some of the issues related to the risk to human health from the intake of various residues via food [ 32 , 33 , 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Exposure Assessment of Veterinary Antibiotics in Pork Meat on Children and Adolescents in Cyprus

Kyriakides

Lazaris

Arsenoglou

et al. 2020

Foods

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In recent years, huge amounts of antibiotics have been administered to farm animals, and as a result, residues of these antibiotics can accumulate in livestock products and, once consumed, may be transmitted to humans. Farm animals’ antibiotic treatment may therefore present a risk for consumers health, especially for children and adolescents. In children, the immune system is not fully developed, and thus, they are more susceptible than adults to resistant bacteria. A dietary exposure assessment was conducted on veterinary antibiotics found in raw pork meat among children and adolescents in Cyprus, since pork is the most consumed red meat in Cypriot population. The study was based on the results of the occurrence of 45 residual antibiotics in raw pork meat samples in Cyprus between 2012 and 2017 in combination with data on the consumption of pork meat on children and adolescents taken from the latest demographic report in Cyprus. Estimated daily intake (EDI) values of veterinary antibiotics for children aged 6–9 years old, were higher compared to EDI values for adolescents aged 10–17 years old. The percentage ratio of the estimated daily intake to the acceptable daily intake for all the veterinary antibiotic residues was less than 5.6. The results indicate that antibiotic residues in pork meat of inland production are below the acceptable daily intake and are of low risk to human health related to the exposure of antibiotics. Nevertheless, continuous exposure to low levels of antibiotic residues in respect to age vulnerability should be of a great concern.

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“…The HPLC method requires laborious sample preparation procedures for biological fluids in order to be able to perform fluorescence detection of corticosteroids [15]. In recent years, LC coupled to electrospray/atmospheric pressure chemical ionization (ESI/APCI) mass spectrometry has been used to determine corticosteroids quantitatively in bodily fluids [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]35,36]. This technique requires the cleaning of samples for good sensitivity and selectivity prior to the analysis of corticosteroids.…”

Section: Introductionmentioning

confidence: 99%

Quantification of corticosteroids in bovine urine using selective solid phase extraction and reversed-phase liquid chromatography/tandem mass spectrometry

Tölgyesi

Sharma

Kovacsics

et al. 2010

Journal of Chromatography B

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Development and validation of a liquid chromatography–electrosprayionization mass spectrometric method for the determination of dexamethasone in sheep plasma

Cited by 13 publications

References 17 publications

Simultaneous quantitation of dexamethasone palmitate and dexamethasone in human plasma by liquid chromatography/tandem mass spectrometry

Simultaneous quantitation of dexamethasone palmitate and dexamethasone in human plasma by liquid chromatography/tandem mass spectrometry

Dietary Exposure Assessment of Veterinary Antibiotics in Pork Meat on Children and Adolescents in Cyprus

Quantification of corticosteroids in bovine urine using selective solid phase extraction and reversed-phase liquid chromatography/tandem mass spectrometry

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