Development and Validation of a Rapid RP‐HPLC Method for the Estimation of Esmolol Hydrochloride in Bulk and Pharmaceutical Dosage Forms

Somasekhar, Vanita; Sankar, D. Gowri

doi:10.1155/2010/470785

Cited by 6 publications

(4 citation statements)

References 8 publications

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“…The results in Table 3 showed that the methods are successful for the determination of drugs and that the excipients in the dosage forms do not interfere. The results are compared to the available validated reported [14][15][16][17][18] methods on each drug and the results agree well with the claim and also are in agreement with the results obtained by the literature method. Statistical analysis of the results using Student's t-test for accuracy and F-test for precision revealed no significant difference between the proposed methods and the literature method with respect to accuracy and precision.…”

Section: Application To Formulationssupporting

confidence: 84%

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2016

IJPSR

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Simple, sensitive and selective methods are developed for the spectrophotometric determination of drugs, viz., Esmolol hydrochloride (ESM), Ramipril (RAM), Gemifloxacin (GEM), Terazosin (TRZ) and Moxifloxacin (MOX), based on their reactivity towards KMnO 4 . Beer's law is obeyed in the concentration of 4-28, 4-28, 2.6-18.2, 1.5-10.5 and 1-7 μg ml-1 for Esmolol hydrochloride, Ramipril, Gemifloxacin, Terazosin and Moxifloxacin. The methods involve the addition of excess KMnO 4 of known concentration in the presence of 2M H2SO 4 , reactants are allowed to react and the unreacted KMnO 4 is estimated with a fixed amount of Methyl Orange by measuring the absorbance at 507nm. Results of analyses were validated statistically. Statistical comparison of the results with the reference method shows excellent agreement and indicates no significant difference in accuracy and precision. These methods have been applied for the determination of drugs in their pure form as well as in tablet formulations. These methods have been validated in terms of guidelines of ICH.

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Section: Application To Formulationssupporting

confidence: 84%

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2016

IJPSR

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“…The methods which were reported in the literature for the determination of ESM includes Spectrophotometry [45][46][47][48][49][50] , HPLC 51 and chromatography 52,53 methods. Since the abovementioned methods are complex and expensive, there is a need to develop simple, less expensive, and more selective method for the determination of ESM.…”

Section: Esmolol: (Esm) (mentioning

confidence: 99%

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2015

IJPSR

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Simple, sensitive, accurate and precise spectrophotometric methods for quantitative determination of five drugs viz., Tramadol Hydrochloride (TDH) , Dobutamine (DOB), Trimetazidine (TRMZ), Terazocin (TRZ) and Esmolol (ESM) were developed. The method for each drug depends upon oxidation of drugs by Ce (IV) (Excess) and estimating the amount of un reacted Ce (IV) by Rhodamine-B dye at 557 nm. The calibration curves obeyed Beer's law over the concentration range of 14-130μg ml-1 (TDH), 1-14 μg ml-1 (DOB), 8-120μg ml-1 (TRMZ), 16-130 μg ml-1 (TRZ), and 12-84 μg ml-1 (ESM). The methods have been validated in terms of guidelines of ICH and has been applied to the analysis of pharmaceuticals. INTRODUCTION: Tramadol Hydrochloride (TDH) (Fig.1a) is chemically known as Tramadol [(±) Trans-2-(dimethylaminomethyl)-1-(3methoxy-phenyl)-cyclohexanol hydrochloride]. It is a centrally acting opoid analgesic. 1 Tramadol and its metabolite (+)-Odesmethyl-tramadol (M1) are weak agonists of the μ opioid receptor. (+)-Tramadol inhibits serotonin reuptake and (-)tramadol inhibits norepinephrine reuptake. Various methods have been reported for the determination of tramadol in bulk, pharmaceutical preparations, biological fluids and hair including spectrophotometry 2-7 , high performance liquid chromatography (HPLC) 8-11 , potentiometry 12 and chromatography 13 .

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“…Most HPLC methods reported are useful in estimating Esmolol hydrochloride in human plasma [9][10][11][12][13] and biological fluids [14]. HPLC [15,16] methods have been reported for determination of ESM in pharmaceutical injections.…”

Section: Esmolol Hydrochloridementioning

confidence: 99%

Spectrophotometric Determination of Drugs and Pharmaceuticals by Cerium (IV) Amaranth Dye Couple

2013

IOSR-JAC

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Simple, sensitive, accurate, and precise spectrophotometric methods for quantitative determination of drugs, viz., Darifenacin (DAR), Esmolol Hydrochloride (ESM), Montelukast Sodium (MON), Sildenafil citrate (SIL),Terbinafine (TER) and Tramadol Hydrochloride (TRA) were developed. The method of each drug depends upon oxidation of drugs by Ce (IV) (Excess) and estimating the amount of unreacted Ce (IV) by amaranth dye at 523nm. The calibration curves obeyed Beer's law over the concentration range of 1.4-7.0 µg ml-1 (DAR), 2-14 µg ml-1 (ESM), 2-10 µg ml-1 (MON), 20-70 µg ml-1 (SIL), 3-21 µg ml-1 (TER) & 2-14 µg ml-1 (TRA). The methods have been validated in terms of guidelines of ICH and applied to analysis of pharmaceuticals.

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Development and Validation of a Rapid RP‐HPLC Method for the Estimation of Esmolol Hydrochloride in Bulk and Pharmaceutical Dosage Forms

Cited by 6 publications

References 8 publications

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Spectrophotometric Determination of Drugs and Pharmaceuticals by Cerium (IV) Amaranth Dye Couple

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