Development and validation of an LC–MS/MS method for the determination of quetiapine and four related metabolites in human plasma

Davis, Patricia C.; Bravo, Orlando; Gehrke, Mark; Azumaya, Connie T.

doi:10.1016/j.jpba.2009.11.018

Cited by 39 publications

(25 citation statements)

References 22 publications

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“…4c, d, also supports that Mq14-Mq16 are the metabolites. The previous studies on quetiapine metabolism reported Mq1-Mq13 in the first report [15], Mq1, Mq2 and Mq3,4 in the second report [16], and Mq1, Mq2, Mq3,4 and Mq12 in the third report [17], whereas in the present study, three new metabolites Mq14-Mq16 could be detected in addition to the previous Mq1-Mq13. The peaks of newly detected Mq14-Mq16 were higher than those of reported Mq2, Mq5 and Mq10-Mq13, as shown in Fig.…”

Section: Practical Applications and New Drug Metabolites In Human Urinecontrasting

confidence: 50%

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Simultaneous determination of cyclic antidepressants and their related drugs and the estimation of new metabolites in human whole blood and urine by MALDI-QTOF-mass spectrometry

et al. 2016

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A rapid and sensitive method using matrix-assisted laser desorption ionization (MALDI)-quadrupole time-of-flight (QTOF)-mass spectrometry (MS) was developed for the analysis of six tricyclic antidepressants (ADs) and their related drugs, such as amitriptyline, carbamazepine, clomipramine, imipramine, nortriptyline, quetiapine, and two tetracyclic ADs, mianserin and mirtazapine, because these eight drugs are commonly observed medicines in poisoning cases in Japan. In the present MALDI-MS method, the limits of detection were 0.3-2 ng/ mL. The present method provided a simple and high throughput simultaneous analysis of these drugs. This is the first report dealing with quantitation of ADs and their related drugs in biological samples by MALDI-MS. In addition, we applied the MALDI-MS to two authentic cases, and three new metabolites of amitriptyline and three new metabolites of quetiapine could be detected in blood and urine samples in the two cases when regioisomers were counted as one metabolite.

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Section: Practical Applications and New Drug Metabolites In Human Urinecontrasting

confidence: 50%

“…Thirteen metabolites of quetiapine were already assigned by LC-TOF-MS study [15], and the quantification of some of these was performed by LC-MS/MS [16,17]. Therefore, in the present work, the metabolites of quetiapine are named according to the numbering used in the work of Pelander et al [15].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of cyclic antidepressants and their related drugs and the estimation of new metabolites in human whole blood and urine by MALDI-QTOF-mass spectrometry

et al. 2016

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“…As with the other antipsychotic drugs, the majority can be quantified by LC-MS/MS in positive ionisation mode using a C18 column. Liquid-liquid extraction is the sample preparation method of choice for this class of drugs due to the low levels found in plasma [110][111][112][113][114][115][116][117][118][119], SPE may also be useful [120][121][122][123] but protein precipitation is unlikely to provide the necessary sensitivity to allow measurement of the atypical antipsychotics in serum (Table 4).…”

Section: Antidepressantsmentioning

confidence: 99%

Therapeutic drug monitoring and LC–MS/MS

Adaway

Keevil

2012

Journal of Chromatography B

130

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“…Samples were collected, stored at x20 xC and the determinations performed by Bioanalytical Systems (USA) using liquid-liquid extraction, followed by reversed-phase liquid chromatography separation and electrospray ionization-tandem mass spectrometry detection (LC/MS-MS) (Davis et al 2010) as previously described (Nikisch et al 2010a(Nikisch et al , b, 2011. Quantitation ranges for each analyte were from <0.7 to 2000 ng/ml.…”

Section: Csf Quetiapine and Norquetiapine Measurementsmentioning

confidence: 99%

Quetiapine affects neuropeptide Y and corticotropin-releasing hormone in cerebrospinal fluid from schizophrenia patients: relationship to depression and anxiety symptoms and to treatment response

Nikisch

Baumann

Liu

et al. 2011

Int. J. Neuropsychopharm.

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Cumulative evidence indicates that neuropeptides play a role in the pathophysiology of schizophrenia. Early data showed increased neuropeptide Y (NPY) in cerebrospinal fluid (CSF) from schizophrenia patients and data from rodents show that antipsychotic drugs modulate NPY levels in and release from selected rat brain regions. In view of these findings we investigated whether the atypical antipsychotic quetiapine, originally used as an antipsychotic but subsequently shown to be efficient also in major depressive disorder and in both poles of bipolar disorder, would affect NPY-like immunoreactivity (-LI), and corticotropin-releasing hormone (CRH)-LI levels in CSF of schizophrenia patients. NPY-LI and CRH-LI in CSF were determined in 22 patients with schizophrenia. Lumbar puncture was performed at baseline and again after 4 wk of quetiapine treatment (600 mg/d). Patients were assessed with the Positive and Negative Syndrome Scale (PANSS) at baseline and at weekly intervals. Quetiapine treatment was associated with a significant increase in NPY-LI (p<0.001) and decrease in CRH-LI (p<0.01). Stepwise multiple regression analysis revealed that ΔNPY-LI and ΔCRH-LI levels predicted 63% (p<0.001) of the variability of the ΔPANSS total score, ΔNPY-LI 42% (p<0.05) of the ΔPANSS anxiety items (G2) and ΔCRH-LI 40% (p=0.05) of the ΔPANSS depression items (G6). These results suggest that while quetiapine's effects on monoamines are probably related to its antipsychotic properties, the modulation of NPY and CRH accounts for its antidepressant and anxiolytic effects and can be markers of response.

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Development and validation of an LC–MS/MS method for the determination of quetiapine and four related metabolites in human plasma

Cited by 39 publications

References 22 publications

Simultaneous determination of cyclic antidepressants and their related drugs and the estimation of new metabolites in human whole blood and urine by MALDI-QTOF-mass spectrometry

Simultaneous determination of cyclic antidepressants and their related drugs and the estimation of new metabolites in human whole blood and urine by MALDI-QTOF-mass spectrometry

Therapeutic drug monitoring and LC–MS/MS

Quetiapine affects neuropeptide Y and corticotropin-releasing hormone in cerebrospinal fluid from schizophrenia patients: relationship to depression and anxiety symptoms and to treatment response

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