Development and Validation of Analytical Method and Antioxidant Effect for Berberine and Palmatine in &lt;i&gt;P.amurense&lt;/i&gt;

Jang, Gill‐Woong; Choi, Sun‐Il; Han, Xionggao; Men, Xiao; Kwon, Hee-Yeon; Choi, Yong Hwan; Park, Byung-Woo; Kim, Jeong-Jin; Lee, Ok‐Hwan

doi:10.13103/jfhs.2020.35.6.544

Cited by 2 publications

(2 citation statements)

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“…Palmatine is a natural isoquinoline alkaloid with many pharmacological effects, such as anti-oxidation, anti-cancer, wide-spectrum anti-bacterial and anti-virus. − It was developed into a soluble drug as palmatine chloride (PCl) administered for anti-bacterial therapies (Chinese Pharmacopoeia 2020 Edition). Palmatine chloride is composed of one quaternary ammonium cation and one chloride anion (Scheme ).…”

Section: Introductionmentioning

confidence: 99%

“…Cocrystal polymorphism of several racemic (or chiral) pharmaceutical compounds has been reported. 26−30 Palmatine is a natural isoquinoline alkaloid with many pharmacological effects, such as anti-oxidation, 31 anti-cancer, 32 wide-spectrum anti-bacterial and anti-virus. 32−34 It was developed into a soluble drug as palmatine chloride (PCl) administered for anti-bacterial therapies (Chinese Pharmacopoeia 2020 Edition).…”

Section: ■ Introductionmentioning

confidence: 99%

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Two Cocrystal Polymorphs of Palmatine Chloride with Racemic Hesperetin

Zhang

Liu

et al. 2021

Crystal Growth & Design

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Two polymorphic cocrystals of palmatine chloride with racemic hesperetin (Form I and Form II) have been prepared and investigated systematically. Crystal structure analysis reveals that reliable O-H•••Cl − hydrogen-bonding interactions exist in both cocrystal polymorphs. However, similar O-H•••Cl − hydrogen-bonding interactions resulted in completely different supramolecular arrangements. Cocrystal Forms I and II are non-hygroscopic and show high stability against temperature, humidity, and light. The cocrystal formation greatly lowers the solubility of palmatine chloride, while the solubility of hesperetin has been improved. Sustained release of palmatine chloride and enhanced release of hesperetin from two cocrystal polymorphs in pure water were achieved.

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