After a product has undergone a manufacturing process, it usually has several important quality characteristics. When the process quality of all quality characteristics meets the requirements of the quality level, the process quality of the product can be guaranteed to satisfy customers’ needs. A large number of studies have pointed out that good process quality can raise product yield and product value; at the same time, it can reduce the ratio of rework and scrap, achieve the effect of energy saving and waste reduction, and contribute to the sustainable operation of enterprises as well the environment. Since the six sigma method combines the statistical analysis method of manufacturing cost and production data, it is a useful tool for process improvement and process quality enhancement. Therefore, this paper adopted the six sigma-define, measure, analyze, improve and control (DMAIC) improvement process to lift the manufacturing process quality of multi-characteristic products. Besides, the Taguchi process capability index is one of the commonly used tools for quality assessment in the industry. Not only can it reflect the process loss, but it also can ensure the process yield when the index value is large enough. Consequently, this paper discussed the relationship between the Taguchi process capability index and the six sigma quality level. Meanwhile, the entire six sigma DMAIC improvement process was built on the basis of the process capability index and developed by the method of statistical quality control. Hence, the proposed method is very convenient for process engineers to apply, as well as is helpful for enterprises to move toward the goal of smart manufacturing and sustainability.