Development and validation of LC–MS method for the determination of heptaethylene glycol monomethyl ether in benzonatate bulk drugs

Katakam, Lakshmi Narasimha Rao; Ettaboina, Santhosh Kumar; Marisetti, Vishnu Murthy

doi:10.1002/bmc.5096

Cited by 14 publications

(10 citation statements)

References 21 publications

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“…The main aim while developing a new chromatography method was to develop a single method for separation of enantiomers of rivaroxaban (Impurity‐C) along with Impurity‐A, Impurity‐B, Impurity‐D, Impurity‐E and degradants from rivaroxaban. To achieve the separation of non‐chiral impurities and chiral impurity together from rivaroxaban, a chiral stationary phase was chosen as the first choice (Durga rao, Kalyanraman, et al, 2010; Katakam, Ettaboina, & Dongala, 2021; Katakam, Ettaboina, & Marisetti, 2021). Initially the separation was tried in the normal phase with various chiral columns, namely, Chiral Pak AD‐H, Chiralcel OJ‐H, Chiralcel OD‐H, Chiral Pak‐IB, and Chiral Pak‐IA, and the mobile phase with different ratios of n ‐hexane, methanol, dichloromethane, and 2‐propanol was used.…”

Section: Resultsmentioning

confidence: 99%

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Stability‐indicating HPLC method development and validation of rivaroxaban impurities and identification of forced degradation products using LC–MS/MS

Vijaykumar

Y.²,

Aparna

et al. 2022

Biomedical Chromatography

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The current aim of this study is to develop a simple, sensitive, and robust analytical method that can separate the Rivaroxaban and its related impurities by using HPLC.This new method can separate enantiomers and all the process-related impurities of rivaroxaban. This method can also be used to determine the assay of rivaroxaban in drug substances and drug products. This new method was developed using a Chiralpak IC (250 Â 4.6 mm, 5 μm) column at 27 C with a gradient program of 25.0 min at a flow rate of 0.8 mL/min. Mobile phase A consisted of acetonitrile, ethanol, and n-butyl amine in the ratio of 95:5:0.5 (v/v/v), respectively. Mobile phase B consisted of a mixture of Milli-Q water, methanol, and n-butyl amine in the ratio of 50:50:0.5 (v/v/v), respectively. The detector wavelength was 254 nm. Rivaroxaban was subjected to the forced degradation conditions (stress conditions) of hydrolysis, base, acid, thermal, photolysis, and oxidation. The degradation products were well separated from rivaroxaban peak and enantiomer peak, and its potential impurities prove the stability-indicating power of the method. The proposed new stability-indicating method was validated with respect to specificity, precision, accuracy, limit of quantification, limit of detection, linearity robustness, and roundness per International Conference on Harmonization guidelines. The %RSD (relative standard deviation) for six sample preparations for rivaroxaban and impurities less than 10% and the recovery is between 90 and 110%. The current method can be used in quality control labs for analysis of commercial products.

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Section: Resultsmentioning

confidence: 99%

“…Durga rao, Kalyanraman, et al, 2010;Katakam, Ettaboina, & Marisetti, 2021). Initially the separation was tried in the normal phase with various chiral columns, namely, Chiral Pak AD-H, Chiralcel OJ-H, Chiralcel OD-H, Chiral Pak-IB, and Chiral Pak-IA, and the mobile phase with different ratios of n-hexane, methanol, dichloromethane, and 2-propanol was used.…”

mentioning

confidence: 99%

Stability‐indicating HPLC method development and validation of rivaroxaban impurities and identification of forced degradation products using LC–MS/MS

Vijaykumar

Y.²,

Aparna

et al. 2022

Biomedical Chromatography

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“…[24] The fire program is sophisticated Single, with sensors Powerful UAV When used, in Europe Another venture Internal show and infrared Low charge with cameras Uses UAVs .In this undertaking, UAVs are closer Provides images and facts Act as neighborhood sensors ,UAVs shooting program Sophisticated sensors Uses single, powerful UAV with, In Europe at the equal time Another challenge is the inner show And low with infrared Price makes use of UAVs. Cameras In this project, UAVs Close-up pics and As local sensors that provide As nearby sensors that provide Traditionally ,Surveillance by using UAVs by the military And are used for espionage operations .However, sturdy Wi-Fi networking With the arrival of generation [25]Monitoring the unfold of large wildfires /Tracking. Six degrees Dynamic UAV with independence Using the sample, no Distribution version wildfire Monitoring and detection Verified Existing literature and the aforementioned of research Based at the evaluation, Many in the literature Methods are deliberate Multiple sensor integration And assorted Of facts structure Under integration.…”

Section: Surveillancementioning

confidence: 99%

An Detailed Study on Unmanned Aerial Vehicle and Its Surveillance

Sathiyaraj¹,

Ramachandran²,

Soniya³

2022

ese

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Unmanned aerial vehicle Image processing using (modification) Using intermediate filtration and Holding three. In Korea, Holding multiple and three. Unmanned Aerial Vehicle (UAV) is the military and defense Important for use Is technology. In unknown areas Surveillance, forest protection and the enemy The UAV can be used to perform various tasks such as spying on territory the use of this research is to spy on the enemy in the war zone to watch Aims to simulate the situation. In the experiment Used site Parrot AR. Drone Ver.2.0, a miniature created by Parrot SA Quad ratter. This quadrant is built by the Robot Operating System (ROS) is controlled. The quarterback searched for and identified some items Find them. Many to do the work Algorithms were used. Ado Post classifier and pinhole algorithm identify the object were used to view. The average error in all situations is only 0.24 m The quartet is controlled by the robot operating.

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“…These biodiesel fuels are usually residues of rapeseed, soybean, saffron, peanut, sunflower, coconut, cotton seed or other vegetable oils. In Germany, the most common biodiesel is rapeseed oil methyl ester, while in the United States it is mainly soy methyl ester [38]. Biodiesel generally emits up to 60% less CO and 80% NOx, and the overall increase in biodiesel emissions is due to emissions of benzene and aldehydes with biodiesel fuels.…”

Section: Biodieselmentioning

confidence: 99%

A Review on Various Biofuels and its Applications

Sherief

Anand²,

Ramachandran³

et al. 2022

JEMM

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Biofuels derived from biofuels, plant or algae or animal wastes. Unlike fossil fuels such as petroleum, coal and natural gas, refilled immediately. Biofuels are fuels made from recently harvested plants. They act like fossil fuels: they burn when ignited, releasing energy that can be converted into kinetic energy in a car, or heat a home. Biofuels can be obtained from a variety of crops and from a wide range of plant products from other industries. Not only is biodiesel stable, it is also a highly environmentally friendly, clean burning option that can be used without modification in diesel engines. In fact, biodiesel reduces greenhouse gas emissions by 56% to 86%, which means that the use of biodiesel has already reduced carbon emissions by 75.5 million metric tons. Many countries promote the use of biodiesel. In 2001, global biodiesel consumption was approximately 0.3 billion gallons. Based on the raw material, biofuels are divided into four groups: third, fourth (FGBs), first biodiesel, which is the only is a locally produced, clean-burning, renewable alternative to petroleum diesel. The use of biodiesel as a vehicle fuel enhances energy conservation, improves air quality and the environment, and provides safety benefits. Biofuels are transport fuels such as ethanol and biomass based diesel fuels. These fuels are usually blended with petroleum fuels (petrol and distillation / diesel fuel and heating oil), but can also be used on their own. Scientists have found that, in practice, biofuels produced from agricultural crops cause less pollution and greenhouse gas emissions than conventional fossil fuels, causing some environmental problems. Biofuels can also affect the poor. Various problems arise due to high prices for crops. It can go from improved water quality to creating new jobs in economically backward areas. Some applications of bioenergy require a feed based on residues from dedicated field production (such as energy crops) or agricultural production. However, many plant species grown for biofuels release higher levels of the ozone precursor isoprene than conventional crops and plants. Excess ozone poses a well-documented risk to human health, with 22,000 premature deaths each year linked to ground ozone exposure in Europe.

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Development and validation of LC–MS method for the determination of heptaethylene glycol monomethyl ether in benzonatate bulk drugs

Cited by 14 publications

References 21 publications

Stability‐indicating HPLC method development and validation of rivaroxaban impurities and identification of forced degradation products using LC–MS/MS

Stability‐indicating HPLC method development and validation of rivaroxaban impurities and identification of forced degradation products using LC–MS/MS

An Detailed Study on Unmanned Aerial Vehicle and Its Surveillance

A Review on Various Biofuels and its Applications

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