Development and Validation of Liquid Chromatography- Mass Spectroscopy/Mass Spectroscopy Method for Quantitative Analysis of Naproxen in Human Plasma after Liquid-Liquid Extraction

Abstract

Purpose: To determine naproxen levels in human plasma using a new liquid chromatography-Mass spectroscopy/Mass spectroscopy (LC-MS/MS) method that involves

A comparative study of the novel spectrophotometric methods versus conventional ones for the simultaneous determination of Esomeprazole magnesium trihydrate and Naproxen in their binary mixture

“…It works by inhibiting both the COX-1 and COX-2 enzymes. Literature survey reveals that there are some UV [10][11][12][13][14] and HPLC [15][16][17][18], HPTLC [19], UPLC [17], LC/MS [20,21], Capillary electrophoresis [22] methods for the estimation of Naproxen in pharmaceutical formulations, and in rat serum by HPTLC [23]. The official method for independent determination of Naproxen is by acid-base titration and that for Esomeprazole magnesium is by HPLC [24].…”