Development and validation of mathematical models for testing antifungal activity of different essential oils against Candida species

Perić, Mirjana; Rajković, Katarina; Milić‐Lemić, Aleksandra; Živković, Rade; Arsenijevic, Valentina Arsić

doi:10.1016/j.archoralbio.2018.11.029

Cited by 8 publications

(3 citation statements)

References 37 publications

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“…In this investigation, LAEO exhibited considerable antifungal effects against C. albicans sputum isolates. Our results correlate with those of several previous studies in which MIC values for LAEO range between 0.5–2% [ 30 , 31 ]. However, LAEO MIC 50 and MIC 90 values were twice higher than the values obtained in the previous experiments.…”

Section: Discussionsupporting

confidence: 92%

Antifungal Activity of Lavandula angustifolia Essential Oil against Candida albicans: Time-Kill Study on Pediatric Sputum Isolates

et al. 2022

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The aim of our study was to determine the susceptibility of 15 Candida albicans sputum isolates on fluconazole and caspofungin, as well as the antifungal potential of Lavandula angustifolia essential oil (LAEO). The commercial LAEO was analyzed using gas chromatography-mass spectrometry. The antifungal activity was evaluated using EUCAST protocol. A killing assay was performed to evaluate kinetics of 2% LAEO within 30 min treatment. LAEO with major constituents’ linalool (33.4%) and linalyl acetate (30.5%) effective inhibited grows of C. albicans in concentration range 0.5–2%. Fluconazole activity was noted in 67% of the isolates with MICs in range 0.06–1 µg/mL. Surprisingly, 40% of isolates were non-wild-type (non-WT), while MICs for WT ranged between 0.125–0.25 µg/mL. There were no significant differences in the LAEO MICs among fluconazole-resistant and fluconazole-susceptible sputum strains (p = 0.31) and neither among caspofungin non-WT and WT isolates (p = 0.79). The 2% LAEO rapidly achieved 50% growth reduction in all tested strains between 0.2 and 3.5 min. Within 30 min, the same LAEO concentration exhibited a 99.9% reduction in 27% isolates. This study demonstrated that 2% solution of LAEO showed a significant antifungal activity which is equally effective against fluconazole and caspofungin susceptible and less-susceptible strains.

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Section: Discussionsupporting

confidence: 92%

Antifungal Activity of Lavandula angustifolia Essential Oil against Candida albicans: Time-Kill Study on Pediatric Sputum Isolates

et al. 2022

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“…With a concentration higher than that of this study, the use of the MTT assay has been reported to measure the antitumoral potential of citrus fruits such as C. maxima, C. lemon and C. reticulata against Dalton's lymphoma ascites cells [37]. It has also been used to measure the growth and viability of lung cancer cells using tangerine peel [38]; (Table 4), similar to that reported where the antifungal activity of the essential oil of C. paradisi was evaluated on C. albicans strains isolated from patients with subprosthetic stomatitis with an average inhibition of 12.6 mm [14], likewise, studies have evaluated the minimum fungicidal concentration of C. paradisi against C. albicans isolated from patients with prosthetic stomatitis, reporting a broad spectrum of fungicidal activity at concentrations of 0.1 -16 μg/ml [39], however, these results coincide with the studies where it is demonstrated that the essential oil presents an inhibitory effect against clinical isolates of Candida.…”

Section: Resultssupporting

confidence: 56%

Evaluation of the Essential Oil of <i>Citrus paradisi</i> as an Alternative Treatment against <i>Candida albicans</i>

Delgado¹,

Velázquez²,

González³

et al. 2020

OJST

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Introduction: The World Health Organization establishes that 80% of the world's population uses traditional medicine for their primary care, because they contain compounds responsible for their properties. Objective: To evaluate the antifungal effect of the essential oil of Citrus paradisi against C. albicans and the cytotoxic effect in three cell lines in vitro. Methods: The phytochemical characterization of the oil was carried out by chemical methods and Gas chromatography (GC-MS) and the antifungal effect against C. albicans (ATCC 90029) was evaluated by the Kirby-Bauer method, which evaluated concentrations of 0.75-20 μg/mL and compared with nystatin 100,000 Ul/mL as a positive control. The percentage of the relative inhibitory effect was calculated. The minimum inhibitory concentration (MIC) was determined at 24 hours. Moreover, the cytotoxic effect on C. albicans and cell lines was determined by the colorimetric MTT tetrazolium assay. Finally, the antifungal effect against Candida strains isolated from clinical samples was evaluated at a concentration of 20 μg/mL. Results: The essential oil showed an antifungal effect with a percentage of inhibition of 123%. The MIC was 2.5 μg/mL, and the cytotoxicity index was 5.44 μg/mL for C. albicans. The IC 50 values were 21.060, 9.482 and 4.176 μg/mL for Vero E6, J774A.1 and MDBK cells respectively. Conclusion: These results show the use of C. paradisi essential oil as an alternative treatment in oral antifungal therapy, it is beneficial due to its antifungal effect and its low toxicity on cell cultures.

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“…NNs with genetic algorithm models and surface response models were found operative and reliable in optimizing the minimum effective dosage of tested EOs for Candida spp. Such models reduce the number of experiments and shorten the time needed for determining the optimal antifungal doses of EOs (Perić et al, 2019). RF and gradient boosting machine (GBM) predictive models were applied to describe and predict prevalence of Listeria spp.…”

Section: Discussionmentioning

confidence: 99%

Machine learning approach for predicting Fusarium culmorum and F. proliferatum growth and mycotoxin production in treatments with ethylene-vinyl alcohol copolymer films containing pure components of essential oils

Tarazona

Mateo

Gómez

et al. 2021

International Journal of Food Microbiology

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Development and validation of mathematical models for testing antifungal activity of different essential oils against Candida species

Cited by 8 publications

References 37 publications

Antifungal Activity of Lavandula angustifolia Essential Oil against Candida albicans: Time-Kill Study on Pediatric Sputum Isolates

Antifungal Activity of Lavandula angustifolia Essential Oil against Candida albicans: Time-Kill Study on Pediatric Sputum Isolates

Evaluation of the Essential Oil of <i>Citrus paradisi</i> as an Alternative Treatment against <i>Candida albicans</i>

Machine learning approach for predicting Fusarium culmorum and F. proliferatum growth and mycotoxin production in treatments with ethylene-vinyl alcohol copolymer films containing pure components of essential oils

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Development and validation of mathematical models for testing antifungal activity of different essential oils against Candida species

Cited by 8 publications

References 37 publications

Antifungal Activity of Lavandula angustifolia Essential Oil against Candida albicans: Time-Kill Study on Pediatric Sputum Isolates

Antifungal Activity of Lavandula angustifolia Essential Oil against Candida albicans: Time-Kill Study on Pediatric Sputum Isolates

Evaluation of the Essential Oil of &lt;i&gt;Citrus paradisi&lt;/i&gt; as an Alternative Treatment against &lt;i&gt;Candida albicans&lt;/i&gt;

Machine learning approach for predicting Fusarium culmorum and F. proliferatum growth and mycotoxin production in treatments with ethylene-vinyl alcohol copolymer films containing pure components of essential oils

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Evaluation of the Essential Oil of <i>Citrus paradisi</i> as an Alternative Treatment against <i>Candida albicans</i>