2022
DOI: 10.3389/fonc.2022.1025397
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Development and validation of prognostic models for colon adenocarcinoma based on combined immune-and metabolism-related genes

Abstract: BackgroundThe heterogeneity of tumor tissue is one of the reasons for the poor effect of tumor treatment, which is mainly affected by the tumor immune microenvironment and metabolic reprogramming. But more research is needed to find out how the tumor microenvironment (TME) and metabolic features of colon adenocarcinoma (COAD) are related.MethodsWe obtained the transcriptomic and clinical data information of COAD patients from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Consensus… Show more

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Cited by 4 publications
(2 citation statements)
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“…2.7 Drug sensitivity analyses GDSC (https://www.Cancerrxgene.org) was used to access the chemotherapy drugs of LUSC. The IC50 of the drug in each sample was calculated using the R-package 'pRRophetic' (version 0.5) [11] . Target genes of drugs with signi cant sensitivity differences were predicted through the DrugBank database (https://go.drugbank.com/).…”
Section: Creation Of the Nomogrammentioning
confidence: 99%
“…2.7 Drug sensitivity analyses GDSC (https://www.Cancerrxgene.org) was used to access the chemotherapy drugs of LUSC. The IC50 of the drug in each sample was calculated using the R-package 'pRRophetic' (version 0.5) [11] . Target genes of drugs with signi cant sensitivity differences were predicted through the DrugBank database (https://go.drugbank.com/).…”
Section: Creation Of the Nomogrammentioning
confidence: 99%
“…The relative predictive ability of the immune-and CAFassociated model described in this study was compared with the predictive ability of four previously-described prognostic models (12)(13)(14)(15). To ensure the comparability of these signatures, the same method for calculating and converting the RS was applied to the entire TCGA-COAD cohort.…”
Section: Comparison Of the Icrg Prognostic Forecasting Model With Oth...mentioning
confidence: 99%