Development and validation of the simple
and sensitive spectrophotometric method
of sulphanilamides determination with
4-(2-thiazolylazo)-resorcinol in veterinary preparations

Smolinska, M.; Korkuna, O.; Vrublevska, Teodoziya; Rudchuk, Petro; Teslyar, G.Yu.

doi:10.1515/chem-2015-0139

Cited by 6 publications

(6 citation statements)

References 29 publications

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“…In the present paper, we discuss three liquid-liquid extraction-chromogenic systems containing V(V), XMZ and thiazolylazo dye {TAR, MTAR or 6-hexyl-4-(2-thiazolylazo)resorcinol (HTAR)}. In contrast to TAR and MTAR, which have been the subject of many experimental and theoretical studies, 26,31,36,45 HTAR is unexplored reagent. According to the manufacturer, this reagent is part of a collection of rare and unique chemicals.…”

Section: Introductionmentioning

confidence: 99%

Extraction-Chromogenic Systems for Vanadium(V) Based on Azo Dyes and Xylometazoline Hydrochloride

Hristov¹,

Milcheva²,

Gavazov³

2019

ACSi

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Liquid-liquid extraction-chromogenic systems for vanadium(V) based on xylometazoline hydrochloride (XMZ) and azo derivatives of resorcinol (ADRs) were studied. The following ADRs were used: 4-(2-thiazolylazo)resorcinol (TAR), 5-methyl-4-(2-thiazolylazo)resorcinol (MTAR), and 6-hexyl-4-(2-thiazolylazo)resorcinol (HTAR). Concentration of the reagents, pH of the aqueous medium and shaking time were subjects of optimization experiments. The chloroform-extracted ternary complexes were of composition 1:1:1. The molar absorptivity coefficients (ε λ), absorption maxima (λ), constants of extraction (Log K), and fractions extracted (E%) were found to be ε 553 = 2.50 × 10 4 dm 3 mol-1 cm-1 , Log K = 3.5, and E = 96% (ADR = TAR); ε 550 = 1.88 × 10 4 dm 3 mol-1 cm-1 , Log K = 3.4, and E = 98% (ADR = MTAR); and ε 554 = 2.62 × 10 4 dm 3 mol-1 cm-1 , Log K = 5.0, and E = 99.5% (ADR = HTAR). The Sandell's sensitivities and Beer's law limits were determined as well.

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Section: Introductionmentioning

confidence: 99%

Extraction-Chromogenic Systems for Vanadium(V) Based on Azo Dyes and Xylometazoline Hydrochloride

Hristov¹,

Milcheva²,

Gavazov³

2019

ACSi

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“…According to the literature review, an azo coupling reaction between sulphanilamides diazonium salt and phenolic compounds occurs in an alkaline medium at pH 9-11 [31,32,35,36]. To develop a voltammetric technique, the optimal value of the acidity of the medium to obtain the maximum analytical signal was investigated.…”

Section: Effect Of Phmentioning

confidence: 99%

A New Approach for the Voltammetric Determination of Amoxicillin in the Dosage Form Using Azo Coupling Reaction with Sulphanilamide

et al. 2021

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The novel method of amoxicillin (AM) determination has been developed using single-sweep polarography. The proposed method is based on the obtaining of yellow coloured azo compound due to azo coupling reaction of previous diazotized sulphanilamide (SA) (in the medium of 0.6 M hydrochloric acid) with amoxicillin at pH = 9.0 with the further reduction of the formed analytical form on a dropping mercury electrode. Voltammetric determination of amoxicillin is carried out due to the reduction peak of azo group of the obtained azo compound in the presence of 0.05 mol • L À 1 Na 2 B 4 O 7 as a background electrolyte at the potential E c p2 = À 0.55 V and potential sweep rate of 2.5 V • s À 1 . The developed voltammetric method has two linear ranges of the determined concentrations (0.05-2.0) • 10 À 5 mol • L À 1 and (0.2-1.0) • 10 À 4 mol • L À 1 and the high sensitivity: LOD without the removing of unreacted sodium nitrite is 1.1 • 10 À 6 mol • L À 1 , and 7.2 • 10 À 7 mol • L À 1 , when NaNO 2 excess is removed using urea. The developed voltammetric technique of AM determination has been approved during the analyses of tablets and oral suspension.

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“…In particular, we have previously studied the conditions for sulphanilamides diazotization and their subsequent azo copling with hydroxy-substituted azo compounds, namely, with the acid monoazo dye Tropaeolin O (TrO) 30,31 and heterocyclic azo reagents 4-(2-pyridylazo)-resorcinol 30,32 (PAR) and 4-(2-thiazolylazo)-resorcinol (TAR). 30,33 The absorbance maxima of the obtained nitroso disazo compounds at the spectrum range 590-620 nm [30][31][32][33] have been successfully used for the sulphanilamides determination in dosage forms.…”

Section: Structural Formula Characteristicmentioning

confidence: 99%

Development and Validation of the Simple and Sensitive Spectrophotometric Method of Amoxicillin Determination in Tablets using Sulphanilamides

Kostiv

Korkuna

Rydchuk

2020

ACSi

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A rapid, simple and sensitive spectrophotometric method for the determination of amoxicillin (AM) is described. The method is based on the previous sulphanilamide (SA) and sulphathiazole (STZ) diazotization in the medium of 0.6-0.7 M hydrochloric acid and their subsequent interaction with amoxicillin at pH = 10.5 with formation of yellow-colored azo compouds. Effective molar absorptivities at the absorbance maxima at 445 nm (SA) and 448 nm (STZ) for azo compounds were (1.74 ± 0.06) • 10 4 L × mol-1 × cm-1 and (1.97 ± 0.05) • 10 4 L × mol-1 × cm-1 , respectively. Stoichiometric ratios of the components of azo compounds were determined using continuous variations method. Based on the optimum reaction conditions, new methods were developed. These methods allow to determine the amoxicillin in concentration range 1.3-32.9 mg × mL-1 with sulphanilamide and 0.7-27.4 mg × mL-1 with sulphathiazole. The methods were successfully validated for amoxicillin determination in tablets "Amoxil".

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Development and validation of the simple and sensitive spectrophotometric method of sulphanilamides determination with 4-(2-thiazolylazo)-resorcinol in veterinary preparations

Cited by 6 publications

References 29 publications

Extraction-Chromogenic Systems for Vanadium(V) Based on Azo Dyes and Xylometazoline Hydrochloride

Extraction-Chromogenic Systems for Vanadium(V) Based on Azo Dyes and Xylometazoline Hydrochloride

A New Approach for the Voltammetric Determination of Amoxicillin in the Dosage Form Using Azo Coupling Reaction with Sulphanilamide

Development and Validation of the Simple and Sensitive Spectrophotometric Method of Amoxicillin Determination in Tablets using Sulphanilamides

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