Development and Validation of Uv Spectrophotometric and Rp-HPLC Method for Metoprolol Succinate

Syed, Shoaeb Mohammad; Marathe, Rajendra; Mahaparale, P. R.

doi:10.7897/2230-8407.1011315

Cited by 2 publications

(1 citation statement)

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“…The samples for the study were prepared in a before mentioned procedure for separate percent levels. The resulting solutions were subjected to analysis for recovery studies in percent with the aid of calibration curve [12][13][14][15][16][17] . From the calibration data obtained it was found that the regression coefficient was less than 1 which is within the limits of Beer lamberts' law.…”

Section: Recovery Studymentioning

confidence: 99%

Development and Validation of UV Spectrophotometric Method for the Estimation of Fluconazole in the Marketed Dosage Formulations

Syed¹,

Rp²

2020

PBJ

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The aim of current study was to develop and validate UV Spectrophotometric method for Fluconazole. Ultra Violet Spectroscopy was carried out at 260nm and samples were prepared with a solution of phosphate buffer pH 7.4. The linearity demonstrated a correlation coefficient of 0.998. The method was subjected to validity for the parameters as per ICH guidelines. Correctness, exactness, LOD, LOQ, recovery study and range were determined and the parameters were determined by performing the repeated experiments and proper sampling of the solution. The objective of selection of UV spectroscopy was the simplicity, time and economy of the method furthermore the sensitivity was also high by UV spectroscopy as HPLC technique is costly, time consuming and number of factors may affect the determination. It was observed that, the proposed method was linear, correct, repeatable, error free, selective, specific and cost effective proving the dependability of the method. More over same solvent was used throughout the experimental work and it was found that the method was free from any type of interference from any excipients and method was simple, rapid, precise, accurate and sensitive and can be applied in routine analysis of Fluconazole in single and combined form.

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Section: Recovery Studymentioning

confidence: 99%

Development and Validation of UV Spectrophotometric Method for the Estimation of Fluconazole in the Marketed Dosage Formulations

Syed¹,

Rp²

2020

PBJ

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Influence of Ultrasonication and UV-C Processing on the Functional Characteristics and Anticarcinogenic Activity of Blackthorn Vinegar

Barut Gök,

Yıkmış,

Levent

et al. 2024

ACS Omega

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In recent years, consumer trends have been changing toward fresh food products such as fruit juice, vinegar, etc. that are a good source of bioactive components, high nutritional characteristics, and beneficial microorganisms. Blackthorn (Prunus spinosa L.) vinegar (BV) is one of these nutritious foods. The study aims to examine the efficacy of ultraviolet-C (UV-C) light applied by a modified reactor and ultrasonication on bioactive compounds (total phenolic, total flavonoid, ascorbic acid content, and antioxidant activity) of traditionally produced BV. Furthermore, the volatile organic compound (VOC) profile, hydroxymethylfurfural (HMF) content, cytotoxicity properties, and color were assessed. UV-C light and ultrasonication processes enriched most bioactive components, but these methods did not significantly improve ascorbic acid (p > 0.05) compared to pasteurization. Twenty-seven volatile compounds were analyzed in order to determine the VOC profile. As a result, thermal and nonthermal methods were found to affect the profile significantly (p < 0.05). No significant differences were detected in total soluble solids (4.70−4.77), titratable acidity (3.81−3.87), and pH (3.39−3.41) values. The anticarcinogenic activities of UV-C-treated BVs were more significant than others. Nonthermal treatments were generally better than pasteurization in maintaining and enriching the quality of BV. In this study, UV-C light and ultrasonication technology can be used as an alternative to traditional thermal techniques to improve the quality of BV.

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Development and Validation of Uv Spectrophotometric and Rp-HPLC Method for Metoprolol Succinate

Cited by 2 publications

References 0 publications

Development and Validation of UV Spectrophotometric Method for the Estimation of Fluconazole in the Marketed Dosage Formulations

Development and Validation of UV Spectrophotometric Method for the Estimation of Fluconazole in the Marketed Dosage Formulations

Influence of Ultrasonication and UV-C Processing on the Functional Characteristics and Anticarcinogenic Activity of Blackthorn Vinegar

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