Development, characterization, and <i>in vitro</i> evaluation of water soluble poloxamer/pluronic‐mastic gum‐gum acacia‐based wound dressing

Buyana, Buhle; Aderibigbe, B. A.; Ray, Sirsendu Sekhar; Ndinteh, D. T.; Fonkui, Y.T.

doi:10.1002/app.48728

Cited by 14 publications

(7 citation statements)

References 40 publications

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“…The ethanolic extracts of green and red propolis, despite having hydrophilic compounds in their composition, also have a hydrophobic character, mainly represented by the presence of wax in their composition [89]. The more soluble nature of a dressing may be related to its application in cases where the treatment of the lesion must be performed on sensitive and damaged skin, since this characteristic may be important for the removal of the material to be performed without abrasion to the skin, which demonstrates the potential application of samples F6 to F7 [90].…”

Section: Characterization Of Active and Pure Bc Wound Dressings: Phys...mentioning

confidence: 99%

Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment

et al. 2022

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The use of innate products for the fast and efficient promotion of healing process has been one of the biomedical sector’s main bets for lesion treatment modernization process. The aim of this study was to develop and characterize bacterial cellulose-based (BC) wound dressings incorporated with green and red propolis extract (2 to 4%) and the active compounds p-coumaric acid and biochanin A (8 to 16 mg). The characterization of the nine developed samples (one control and eight active wound dressings) evidenced that the mechanics, physics, morphological, and barrier properties depended not only on the type of active principle incorporated onto the cellulosic matrix, but also on its concentration. Of note were the results found for transparency (28.59–110.62T600 mm−1), thickness (0.023–0.046 mm), swelling index (48.93–405.55%), water vapor permeability rate (7.86–38.11 g m2 day−1), elongation (99.13–262.39%), and antioxidant capacity (21.23–86.76 μg mL−1). The wound dressing based on BC and red propolis was the only one that presented antimicrobial activity. The permeation and retention test revealed that the wound dressing containing propolis extract presented the most corneal stratum when compared with viable skin. Overall, the developed wound dressing showed potential to be used for treatment against different types of dermal lesions, according to its determined proprieties.

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Section: Characterization Of Active and Pure Bc Wound Dressings: Phys...mentioning

confidence: 99%

Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment

et al. 2022

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“…Pluronics or poloxamers are polymers that are insoluble in water that are tasteless, odourless and waxy white granules that have the specific feature of being a thermal gel (77). Because of its thermal sensitivity, pluronic acid can be used in the production of injectable gels (78).…”

Section: Pluronicmentioning

confidence: 99%

pH-Sensitive Polymer-Based Carriers as a Useful Approach for Oral Delivery of Therapeutic Protein: A Review

lori

Ohadi

Estabragh

et al. 2021

PPL

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: There are many proteins and enzymes in the human body, and their dysfunction can lead to disease. The use of proteins as a drug is common in various diseases such as diabetes. Proteins are hydrophilic molecules whose spatial structure is critical to their correct function. There are different ways to the administration of proteins. Protein structures are degraded by gastric acid and enzymes in the gastrointestinal tract and have a slight ability to permeation from the gastrointestinal epithelium due to their large hydrophilic nature. Therefore, their oral use has limitations. Since the oral use of drugs is one of the best and easiest routes for patients, many studies have been done to increase the stability, penetration and ultimately increase the bioavailability of proteins through oral administration. One of the studied strategies for oral delivery of protein is the use of pH-sensitive polymer-based carriers. These carriers use different pH-sensitive polymers such as eudragit®, chitosan, dextran, and alginate. The use of pH-sensitive polymer-based carriers by protecting the protein from stomach acid (low pH) and degrading enzymes, increasing permeability, and maintaining the spatial structure of the protein leads to increased bioavailability. In this review, we focus on the various polymers used to prepare pH-sensitive polymer-based carriers for the oral delivery of proteins.

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“…1 The development of ecologically and bio-friendly functional materials that are exact alternatives to nonbiodegradable petrochemical polymers has been a hot topic for research. [2][3][4] Interdisciplinary materials are under research for the fabrication of novel materials with extra performances. Polyvinyl alcohol (PVA) is a semicrystalline, nontoxic, biodegradable, thermostable, and biocompatible linear synthetic polymer.…”

Section: Introductionmentioning

confidence: 99%

“…Since the world is now focusing on sustainable development and building a green world, protecting our ecosystem from all sorts of pollution and converting waste materials into useful ones must be the major targets 1 . The development of ecologically and bio‐friendly functional materials that are exact alternatives to nonbiodegradable petrochemical polymers has been a hot topic for research 2–4 . Interdisciplinary materials are under research for the fabrication of novel materials with extra performances.…”

Section: Introductionmentioning

confidence: 99%

Development of biopolymer composite films based on chicory extract reinforced polyvinyl alcohol/chitosan blend via green approach for flexible optoelectrical devices

Ramesan,

Kalladi,

Labeeba Abdulla

et al. 2024

J of Applied Polymer Sci

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Biopolymer blend composite films based on polyvinyl alcohol (PVA) and chitosan (CS) incorporated with varying amounts of chicory extract (CE) have been developed by the green solution casting technique. The impact of CE content on structural, thermal, mechanical and electrical properties was thoroughly examined. The existence of intermolecular interactions in the blend composite was confirmed by Fourier‐transform infrared and ultraviolet spectroscopy. The x‐ray diffraction pattern proved the successful preparation of PVA/CS/CE composite film. The scanning electron microscopy images of the composites showed shape and grain size for the different bio‐filler contents. The thermal transition temperature of the blend composites was significantly improved by the addition of CE extract deduced from differential scanning calorimetry. The dielectric study showed that the permittivity remarkably increases with decreasing frequency and maximum dielectric constant was observed for 15 wt% loading. The activation energy obtained from the AC conductivity decreased as the temperature increased. The addition of CE extract improved the hardness and tensile strength of the PVA/CS blend composite in comparison with a pristine pure blend. The controllable mechanical, thermal, optical, and electrical characteristics of the PVA/CS blend composite suggest that it might be an attractive optical material for the advancement of futuristic flexible‐type optoelectronic and energy storage systems.

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Development, characterization, and in vitro evaluation of water soluble poloxamer/pluronic‐mastic gum‐gum acacia‐based wound dressing

Cited by 14 publications

References 40 publications

Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment

Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment

pH-Sensitive Polymer-Based Carriers as a Useful Approach for Oral Delivery of Therapeutic Protein: A Review

Development of biopolymer composite films based on chicory extract reinforced polyvinyl alcohol/chitosan blend via green approach for flexible optoelectrical devices

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